Faecal microbial transplant

Advances in biomarker sciences and technology Pub Date : 2024-01-01 DOI:10.1016/j.abst.2024.02.001

Isreal Ayobami Onifade , Oluwatomiwa Jubilee Sunbare-Funto , Chinedu Endurance Mbah , Oluwatosin Akinola Ajibade , Olubukola Monisola Oyawoye , Abdullahi Tunde Aborode , Seto Charles Ogunleye , Abdullahi Jamiu , Basit Bolarinwa , Mosope F. Abanikannda , Zainab Tiamiyu , Abidemi Ruth Idowu , Oluwatobiloba Ige , Opara Julia Kelechi , Jeremiah I. Abok , Eniola A. Lawal , Ibude Jane Aruorivwooghene , Adekunle Fatai Adeoye , Olowo Roqeebah , Emmanuel Akinloye Ojewole , Ridwan Olamilekan Adesola

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Abstract

Faecal Microbial Transplantation (FMT), have been shown to be successfully managed along with a variety of gastrointestinal disorders, including Clostridioides difficile infection (CDI), inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). FMT is a medical procedure that involves a donor transferring healthy gut bacteria to the recipient. The effectiveness of FMT is thought to be due to the ability of the healthy gut to restore balance to the recipient's microbiome, which is the community of microorganisms that inhabit the gastrointestinal tract. One of the key advantages of FMT is that it is a relatively simple and low-cost treatment option, compared to other therapies that may be more invasive or require long-term medication use. However, FMT is not without its limitations, including the potential for the transfer of infectious agents from the donor to the recipient and the potential for negative side effects in some patients. In this research, we discuss the current state of the evidence on FMT, including its potential benefits and risks, as well as future directions for research in this area.

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粪便微生物移植

粪便微生物移植（FMT）已被证明可以成功控制各种胃肠道疾病，包括艰难梭菌感染（CDI）、炎症性肠病（IBD）和肠易激综合征（IBS）。FMT 是一种医疗程序，由供体将健康的肠道细菌转移给受体。FMT 的有效性被认为是由于健康肠道能够恢复受体微生物组的平衡，而微生物组是居住在胃肠道中的微生物群落。FMT 的主要优势之一是，与其他可能更具侵入性或需要长期用药的疗法相比，它是一种相对简单且成本较低的治疗方案。然而，FMT 也并非没有局限性，包括可能将传染性病原体从供体转移到受体，以及可能对某些患者产生负面影响。在本研究中，我们将讨论 FMT 目前的证据状况，包括其潜在的益处和风险，以及该领域未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in biomarker sciences and technology Biotechnology, Clinical Biochemistry, Molecular Medicine, Public Health and Health Policy

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20 weeks