Cholesterol: A friend to viruses.

IF 4.3 4区 医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-02-19 DOI:10.1080/08830185.2024.2314577
Yingchun Wang, Lifen Gao
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Abstract

Cholesterol is a key life-sustaining molecule which regulates membrane fluidity and serves as a signaling mediator. Cholesterol homeostasis is closely related to various pathological conditions including tumor, obesity, atherosclerosis, Alzheimer's disease and viral infection. Viral infection disrupts host cholesterol homeostasis, facilitating their own survival. Meanwhile, the host cells strive to reduce cholesterol accessibility to limit viral infection. This review focuses on the regulation of cholesterol metabolism and the role of cholesterol in viral infection, specifically providing an overview of cholesterol as a friend to promote viral entry, replication, assembly, release and immune evasion, which might inspire valuable thinking for pathogenesis and intervention of viral infection.

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胆固醇病毒的朋友
胆固醇是一种维持生命的关键分子,它能调节膜的流动性并充当信号介质。胆固醇平衡与各种病理状况密切相关,包括肿瘤、肥胖、动脉粥样硬化、阿尔茨海默病和病毒感染。病毒感染会破坏宿主细胞的胆固醇平衡,从而促进宿主细胞的生存。与此同时,宿主细胞努力降低胆固醇的可及性,以限制病毒感染。本综述侧重于胆固醇代谢的调控和胆固醇在病毒感染中的作用,特别是概述了胆固醇作为促进病毒进入、复制、组装、释放和免疫逃避的朋友,这可能会启发人们对病毒感染的发病机制和干预进行有价值的思考。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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