Tabelecleucel is effective in EBV-positive lymphoproliferative disease

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-02-19 DOI:10.1038/s41571-024-00873-3
Diana Romero
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Tabelecleucel 对 EBV 阳性淋巴组织增生性疾病有效
异基因造血干细胞移植(HSCT)或实体器官移植(SOT)后,可能会出现爱泼斯坦-巴氏病毒(EBV)阳性淋巴组织增生性疾病。尽管约有50%的患者会复发,且预后较差,但包括利妥昔单抗在内的多种治疗方案可用于该病患者。现在,III 期 ALLELE 试验的结果表明,Tabelecleucel 这种来自 EBV 血清阳性供体的 "现成 "多克隆 EBV 特异性 T 细胞产品在这种情况下具有良好的疗效。造血干细胞移植后对利妥昔单抗复发和/或难治的EBV阳性淋巴组织增生性疾病患者(14例)或SOT后对利妥昔单抗和化疗复发和/或难治的EBV阳性淋巴组织增生性疾病患者(29例)接受了三次tabelecleucel输注(每次2×106个细胞)。造血干细胞移植组和SOT组的客观反应率(ORR)分别为主要终点。
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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