Effects of the Immunocontraceptive Gonacon on Pregnancy in Brucella-Seropositive American bison (Bison bison).

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES Journal of Wildlife Diseases Pub Date : 2024-04-01 DOI:10.7589/JWD-D-21-00168

Rebecca K Frey, Morgan E Wehtje, Pauline Nol, Patrick R Clarke, Jack C Rhyan, Matthew P McCollum, Lowell A Miller, Douglas C Eckery

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Abstract

The purpose of this study was to determine if the number of pregnancies in naturally infected Brucella abortus-positive bison (Bison bison) cows would be reduced over a period of 5 yr after one treatment with 3000 µg gonadotropin-releasing hormone immunocontraceptive (GonaCon) compared to a similar group of naturally infected B. abortus-positive bison cows not treated with GonaCon. In each of the 5 yr, GonaCon-treated cows produced fewer offspring in relation to number of cows than the nontreated cows. Fisher's Exact test comparing offspring produced during the first reproductive season showed a significant difference between the two groups (P=0.0028). Differences in number of calves produced in GonaCon-treated and control groups were also noted in remaining years, but statistics were not applied because of data constraints. These data indicate that one treatment with GonaCon in brucellosis-seropositive female bison reduced pregnancies over five reproductive years. Thus, immunocontraception could potentially be used to manage brucellosis in affected herds.

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免疫抑制剂 Gonacon 对布鲁氏菌血清反应阳性野牛怀孕的影响。

本研究的目的是确定，与未使用 GonaCon 治疗的同类自然感染流产布鲁氏菌阳性野牛（野牛）相比，使用 3000 µg 促性腺激素释放激素免疫抑制剂（GonaCon）治疗一次后，自然感染流产布鲁氏菌阳性野牛的怀孕数量是否会在 5 年内减少。在 5 年中的每一年，接受过 GonaCon 治疗的奶牛与未接受治疗的奶牛相比，所产后代数量较少。费雪精确检验比较了第一个繁殖季节的后代，结果显示两组之间存在显著差异（P=0.0028）。在其余年份，经 GonaCon- 处理组和对照组生产的犊牛数量也存在差异，但由于数据限制，没有进行统计。这些数据表明，对布鲁氏菌血清反应阳性的雌性野牛进行一次 GonaCon 治疗后，在五个繁殖年中的怀孕率降低了。因此，免疫抑制剂有可能用于控制受影响牛群的布鲁氏菌病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Wildlife Diseases 农林科学-兽医学

CiteScore

2.70

自引率

0.00%

发文量

213

审稿时长

6-16 weeks

期刊介绍： The JWD publishes reports of wildlife disease investigations, research papers, brief research notes, case and epizootic reports, review articles, and book reviews. The JWD publishes the results of original research and observations dealing with all aspects of infectious, parasitic, toxic, nutritional, physiologic, developmental and neoplastic diseases, environmental contamination, and other factors impinging on the health and survival of free-living or occasionally captive populations of wild animals, including fish, amphibians, reptiles, birds, and mammals. Papers on zoonoses involving wildlife and on chemical immobilization of wild animals are also published. Manuscripts dealing with surveys and case reports may be published in the Journal provided that they contain significant new information or have significance for better understanding health and disease in wild populations. Authors are encouraged to address the wildlife management implications of their studies, where appropriate.