Application of metabolomics in oral squamous cell carcinoma.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-09-01 Epub Date: 2024-02-20 DOI:10.1111/odi.14895

Guanfa Luo, Shuai Wang, Wen Lu, Wei Ju, Jianhong Li, Xiao Tan, Huiting Zhao, Wei Han, Xihu Yang

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Abstract

Background: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy affecting the head and neck region. The prognosis for OSCC patients remains unfavorable due to the absence of precise and efficient early diagnostic techniques. Metabolomics offers a promising approach for identifying distinct metabolites, thereby facilitating early detection and treatment of OSCC.

Objective: This review aims to provide a comprehensive overview of recent advancements in metabolic marker identification for early OSCC diagnosis. Additionally, the clinical significance and potential applications of metabolic markers for the management of OSCC are discussed.

Results: This review summarizes metabolic changes during the occurrence and development of oral squamous cell carcinoma and reviews prospects for the clinical application of characteristic, differential metabolites in saliva, serum, and OSCC tissue. In this review, the application of metabolomic technology in OSCC research was summarized, and future research directions were proposed.

Conclusion: Metabolomics, detection technology that is the closest to phenotype, can efficiently identify differential metabolites. Combined with statistical data analyses and artificial intelligence technology, it can rapidly screen characteristic biomarkers for early diagnosis, treatment, and prognosis evaluations.

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代谢组学在口腔鳞状细胞癌中的应用

背景：口腔鳞状细胞癌（OSCC口腔鳞状细胞癌（OSCC）是影响头颈部的一种常见恶性肿瘤。由于缺乏精确有效的早期诊断技术，OSCC 患者的预后仍然不容乐观。代谢组学为鉴定不同的代谢物提供了一种前景广阔的方法，从而有助于OSCC的早期检测和治疗：本综述旨在全面概述用于早期诊断 OSCC 的代谢标记物鉴定的最新进展。此外，还讨论了代谢标记物在OSCC治疗中的临床意义和潜在应用：本综述总结了口腔鳞状细胞癌发生和发展过程中的代谢变化，并回顾了唾液、血清和 OSCC 组织中特征性、差异性代谢物的临床应用前景。本综述总结了代谢组学技术在 OSCC 研究中的应用，并提出了未来的研究方向：代谢组学是最接近表型的检测技术，能有效识别差异代谢物。结论：代谢组学是最接近表型的检测技术，能有效识别差异代谢物，结合数据统计分析和人工智能技术，可快速筛选出特征性生物标志物，用于早期诊断、治疗和预后评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.