Finding biomarkers of experience in animals.

IF 6.3 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal Science and Biotechnology Pub Date : 2024-02-20 DOI:10.1186/s40104-023-00989-z
Sarah Babington, Alan J Tilbrook, Shane K Maloney, Jill N Fernandes, Tamsyn M Crowley, Luoyang Ding, Archa H Fox, Song Zhang, Elise A Kho, Daniel Cozzolino, Timothy J Mahony, Dominique Blache
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Abstract

At a time when there is a growing public interest in animal welfare, it is critical to have objective means to assess the way that an animal experiences a situation. Objectivity is critical to ensure appropriate animal welfare outcomes. Existing behavioural, physiological, and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative outcomes. But welfare is more than an absence of negative outcomes and an appropriate indicator should reflect the full spectrum of experience of an animal, from negative to positive. In this review, we draw from the knowledge of human biomedical science to propose a list of candidate biological markers (biomarkers) that should reflect the experiential state of non-human animals. The proposed biomarkers can be classified on their main function as endocrine, oxidative stress, non-coding molecular, and thermobiological markers. We also discuss practical challenges that must be addressed before any of these biomarkers can become useful to assess the experience of an animal in real-life.

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寻找动物经验的生物标志物
当公众对动物福利的关注与日俱增的时候,拥有客观的手段来评估动物经历某种情况的方式至关重要。客观性对于确保适当的动物福利结果至关重要。用于评估动物福利的现有行为、生理和神经生物学指标可验证不存在极端负面的结果。但福利不仅仅是没有负面结果,适当的指标应反映动物从负面到正面的全部经历。在这篇综述中,我们借鉴人类生物医学知识,提出了一份候选生物标志物(生物标志物)清单,以反映非人类动物的体验状态。建议的生物标志物可根据其主要功能分为内分泌标志物、氧化应激标志物、非编码分子标志物和热生物标志物。我们还讨论了在这些生物标志物中的任何一种能够用于评估动物在现实生活中的体验之前必须解决的实际挑战。
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CiteScore
10.30
自引率
0.00%
发文量
822
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