Simultaneous determination of tramadol in earwax and urine samples: effects of age, duration time and sex.

IF 1.9 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS Bioanalysis Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI:10.4155/bio-2023-0217

Adnan M Massadeh, Nuseer H Al-Rawi, May T Fayyad, Ali M Shotar, Mudhaffar I Al-Farras, Saif Addeen A Massadeh

引用次数: 0

Abstract

Background: This study aims to determine the concentrations of tramadol in earwax (μg/g) and urine (μg/ml) samples taken from postoperative patients, to evaluate the sensitivity of earwax (cerumen) as an alternative analyte and compare it with the findings in urine samples. Results: The results indicated that tramadol concentrations in earwax samples were averaged 45.08 μg/g (range: 13.5-107.7 μg/g), whereas tramadol concentrations in urine samples were averaged 4.97 μg/ml (range: 1.57-10.11 μg/ml). There were significant differences when comparing age groups, duration and sex between earwax and urine samples (p < 0.05). Conclusion: Despite the significant differences between earwax and urine samples, earwax can be used as a bioindicator of tramadol detection.

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同时测定耳屎和尿液样本中的曲马多：年龄、持续时间和性别的影响。

研究背景本研究旨在测定术后患者耳屎（μg/g）和尿液（μg/ml）样本中曲马多的浓度，评估耳屎（耵聍）作为替代分析物的敏感性，并将其与尿液样本中的结果进行比较。结果显示结果显示，耳屎样本中曲马多的平均浓度为 45.08 微克/克（范围：13.5-107.7 微克/克），而尿液样本中曲马多的平均浓度为 4.97 微克/毫升（范围：1.57-10.11 微克/毫升）。比较耳屎样本和尿液样本的年龄组别、持续时间和性别，两者之间存在明显差异（p 结论：耳屎样本和尿液样本之间存在明显差异：尽管耳屎和尿液样本之间存在明显差异，但耳屎仍可用作曲马多检测的生物指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioanalysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

3.30

自引率

16.70%

发文量

审稿时长

2 months

期刊介绍： Reliable data obtained from selective, sensitive and reproducible analysis of xenobiotics and biotics in biological samples is a fundamental and crucial part of every successful drug development program. The same principles can also apply to many other areas of research such as forensic science, toxicology and sports doping testing. The bioanalytical field incorporates sophisticated techniques linking sample preparation and advanced separations with MS and NMR detection systems, automation and robotics. Standards set by regulatory bodies regarding method development and validation increasingly define the boundaries between speed and quality. Bioanalysis is a progressive discipline for which the future holds many exciting opportunities to further reduce sample volumes, analysis cost and environmental impact, as well as to improve sensitivity, specificity, accuracy, efficiency, assay throughput, data quality, data handling and processing. The journal Bioanalysis focuses on the techniques and methods used for the detection or quantitative study of analytes in human or animal biological samples. Bioanalysis encourages the submission of articles describing forward-looking applications, including biosensors, microfluidics, miniaturized analytical devices, and new hyphenated and multi-dimensional techniques. Bioanalysis delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for the modern bioanalyst.