Manganese(II), copper(II) and silver(I) complexes containing 1,10-phenanthroline/1,10-phenanthroline-5,6-dione against Candida species.

IF 2.5 4区生物学 Q3 MICROBIOLOGY Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI:10.2217/fmb-2023-0212

Rafael M Gandra, Clarissa A Pacheco, Leandro S Sangenito, Lívia S Ramos, Lucieri Op Souza, Pauraic McCarron, Malachy McCann, Michael Devereux, Marta H Branquinha, André Ls Santos

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Abstract

Background: New chemotherapeutics are urgently required to treat Candida infections caused by drug-resistant strains. Methods: The effects of 16 1,10-phenanthroline (phen)/1,10-phenanthroline-5,6-dione/dicarboxylate complexed with Mn(II), Cu(II) and Ag(I) were evaluated against ten different Candida species. Results: Proliferation of Candida albicans, Candida dubliniensis, Candida famata, Candida glabrata, Candida guilliermondii, Candida kefyr, Candida krusei, Candida lusitaniae, Candida parapsilosis and Candida tropicalis was inhibited by three of six Cu(II) (MICs 1.52-21.55 μM), three of three Ag(I) (MICs 0.11-12.74 μM) and seven of seven Mn(II) (MICs 0.40-38.06 μM) complexes. Among these [Mn₂(oda)(phen)₄(H₂O)₂][Mn₂(oda)(phen)₄(oda)₂].4H₂O, where oda = octanedioic acid, exhibited effective growth inhibition (MICs 0.4-3.25 μM), favorable activity indexes, low toxicity against Vero cells and good/excellent selectivity indexes (46.88-375). Conclusion: [Mn₂(oda)(phen)₄(H₂O)₂][Mn₂(oda)(phen)₄(oda)₂].4H₂O represents a promising chemotherapeutic option for emerging, medically relevant and drug-resistant Candida species.

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含 1,10-菲罗啉/1,10-菲罗啉-5,6-二酮的锰(II)、铜(II)和银(I)配合物对念珠菌的作用。

背景：治疗由耐药菌株引起的念珠菌感染急需新的化学疗法。研究方法评估了 16 种 1,10-菲罗啉（phen）/1,10-菲罗啉-5,6-二酮/二羧酸盐与 Mn(II)、Cu(II) 和 Ag(I) 复合物对 10 种不同念珠菌的作用。结果白念珠菌、杜布林念珠菌、法马塔念珠菌、光滑念珠菌、吉利蒙地念珠菌、克菲尔念珠菌、克鲁塞念珠菌、卢西塔尼亚念珠菌、副丝状念珠菌和热带念珠菌的增殖受到六种 Cu（II）中三种的抑制（MICs 1.52-21.55 μM）、三种 Ag(I) 复合物中的三种（MICs 0.11-12.74 μM）和七种 Mn(II) 复合物中的七种（MICs 0.40-38.06 μM）。其中[Mn2(oda)(phen)4(H2O)2][Mn2(oda)(phen)4(oda)2].4H2O（其中oda=辛二酸）表现出有效的生长抑制作用（MICs 0.4-3.25 μM）、良好的活性指数、对 Vero 细胞的低毒性以及良好/卓越的选择性指数（46.88-375）。结论[Mn2(oda)(phen)4(H2O)2][Mn2(oda)(phen)4(oda)2].4H2O 是一种很有前途的化疗选择，可用于治疗新出现的、与医学相关的耐药念珠菌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.