Evaluation of serum adiponectin as a marker of insulin resistance in women with polycystic ovarian syndrome: a comparative cross-sectional study.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Reproductive Biology and Endocrinology Pub Date : 2024-02-20 DOI:10.1186/s12958-024-01196-9

Olugbenga Ojatokunbo Runsewe, Abiodun Adeniyi Adewunmi, Gbenga Olorunfemi, Abimbola Tawaqualit Ottun, Ayokunle Moses Olumodeji, Babalola Ogungbemile, Tamramat Iyabo Runsewe-Abiodun

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Abstract

Background: Insulin resistance (IR) is known to be prevalent amongst women with polycystic ovarian syndrome (PCOS). Its presence has been linked to chronic anovulation and marked long term complications in women. Hence, identification and treatment of IR in women with PCOS is required to prevent the metabolic and reproductive complications of the disease. The aim of this study is to determine if serum adiponectin could be used as a surrogate marker for insulin resistance among women with PCOS.

Materials and methods: A total number of 148 consenting women with PCOS diagnosed using the Rotterdam criteria were recruited for this study. Fifty-two of these women had insulin resistance were compared with 96 of the women who did not have insulin resistance. The serum Adiponectin levels, fasting blood glucose and fasting insulin levels were assayed in all study participants. Insulin resistance was assessed in all the study participants using the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Data were analyzed using relevant inferential statistics at 95% confidence interval and p value of < 0.05.

Results: The prevalence of insulin resistance among the study participants was 35.1%. Majority of the women (83.1%) had a high body mass index (BMI). More than half (68.2%) of the participants were in the age range of 21-30years and 76.4% (113) were nulliparous. There was no statistically significant difference in the median adiponectin level among insulin resistant (3.735 ug/ml) and non-insulin resistant participants vs. (3.705 ug/ml) (p = 0.6762). Both univariate and multivariate regression analysis did not show a statistically significant relationship between adiponectin and insulin resistance in PCOS.

Conclusion: The prevalence of insulin resistance in women with PCOS is high and serum adiponectin is not a suitable surrogate marker of insulin resistance in women with PCOS.

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将血清脂肪连蛋白作为多囊卵巢综合征妇女胰岛素抵抗的标志物进行评估：一项横断面比较研究。

背景：众所周知，胰岛素抵抗（IR）在患有多囊卵巢综合征（PCOS）的妇女中很普遍。胰岛素抵抗的存在与妇女长期无排卵和明显的长期并发症有关。因此，需要识别和治疗多囊卵巢综合症妇女的 IR，以预防该疾病的代谢和生殖并发症。本研究的目的是确定血清脂肪连素是否可用作多囊卵巢综合征妇女胰岛素抵抗的替代标志物：本研究共招募了 148 名同意接受鹿特丹标准诊断的多囊卵巢综合征妇女。其中 52 名妇女有胰岛素抵抗，与 96 名没有胰岛素抵抗的妇女进行了比较。对所有研究参与者的血清脂肪连蛋白水平、空腹血糖和空腹胰岛素水平进行了检测。使用胰岛素抵抗稳态模型评估（HOMA-IR）对所有研究参与者的胰岛素抵抗进行了评估。数据分析采用了相关的推理统计方法，置信区间为 95%，P 值为结果：研究参与者的胰岛素抵抗发生率为 35.1%。大多数妇女（83.1%）的体重指数（BMI）较高。半数以上（68.2%）的参与者年龄在 21-30 岁之间，76.4%（113 人）为非一夫一妻制。胰岛素抵抗参与者（3.735 微克/毫升）和非胰岛素抵抗参与者（3.705 微克/毫升）的脂肪连通素中位数差异无统计学意义（P = 0.6762）。单变量和多变量回归分析均未显示多囊卵巢综合征患者的脂肪连蛋白与胰岛素抵抗之间存在显著的统计学关系：结论：多囊卵巢综合征妇女的胰岛素抵抗发生率很高，血清脂肪连蛋白不是多囊卵巢综合征妇女胰岛素抵抗的替代指标。

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.