Reproductive Biology and Endocrinology最新文献

{"title":"Improved progressive motility recovery with a standardized gradient-based approach for semen preparation in IUI.","authors":"Felix Roth, Felix Haeberlin","doi":"10.1186/s12958-026-01543-y","DOIUrl":"https://doi.org/10.1186/s12958-026-01543-y","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between triglyceride-glucose index and body mass index on pregnancy loss in Chinese women with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial.","authors":"Muxin Guan, Hong Yu, Jiaxing Feng, Mengyi Zhu, Yu Wang, Hang Ge, Baichao Shi, Fengjuan Lu, Jiannan Yu, Zhuwei Gao, Jingshu Gao, Xiaoke Wu","doi":"10.1186/s12958-026-01531-2","DOIUrl":"https://doi.org/10.1186/s12958-026-01531-2","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on a recent published study on endometrial receptivity assessment.","authors":"Yuval Or, Ilan Tur-Kaspa, Tsafrir S Kolatt","doi":"10.1186/s12958-026-01532-1","DOIUrl":"10.1186/s12958-026-01532-1","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"24 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential, perils and pitfalls of Artificial intelligence (AI) in Assisted Reproductive Technologies (ART).","authors":"Akanksha Garg, David B Seifer","doi":"10.1186/s12958-026-01542-z","DOIUrl":"10.1186/s12958-026-01542-z","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phthalates as the silent saboteurs of male fertility via changes in semen quality: a systematic review.","authors":"Swati Dhar, Akash Tomar, Anupama N, Poulomi Chatterjee, Pratik Kumar Chatterjee","doi":"10.1186/s12958-026-01541-0","DOIUrl":"https://doi.org/10.1186/s12958-026-01541-0","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the link between early sexual initiation and endometriosis: evidence from population-based analyses and genetic causal inference.","authors":"Mengying Li, Yimei Ma","doi":"10.1186/s12958-026-01539-8","DOIUrl":"https://doi.org/10.1186/s12958-026-01539-8","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frozen-Thawed ovarian autografts treated with scaffold-based melatonin delivery in rats.","authors":"Luciana Lamarão Damous, Mayara Souza Alves, Larissa Gonçalves Justino, Augusto Chan Ho Son, Nara Macedo Botelho, Marcos Eiji Shiroma, Ana Elisa Teófilo Saturi de Carvalho, José Eduardo Krieger, Peter Chedraui, Edmund Chada Baracat, José Maria Soares-Jr","doi":"10.1186/s12958-026-01540-1","DOIUrl":"10.1186/s12958-026-01540-1","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells.","authors":"Natsuki Miyake, Hidetaka Suga, Satoko Osuka, Tomomi Seki, Reina Sonehara, Ayako Muraoka, Tomoko Nakamura, Bayasula, Tsutomu Miwata, Mika Soen, Mayu Sakakibara, Shiori Go, Saki Hasegawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Hiroshi Arima, Hiroaki Kajiyama","doi":"10.1186/s12958-026-01536-x","DOIUrl":"https://doi.org/10.1186/s12958-026-01536-x","url":null,"abstract":"<p><strong>Background: </strong>Hypothalamic kisspeptin neurons are master regulators of reproduction in mammals, including humans and rodents, via direct stimulation of gonadotropin-releasing hormone (GnRH) neurons. Therefore, they play a central role in puberty onset and gonadal function in mammals. Arcuate kisspeptin neurons express both neurokinin B (NKB) and dynorphin A (Dyn). Thus, these neurons are also referred to as KNDy neurons, and accumulating evidence suggests that KNDy neurons are responsible for tonic GnRH/gonadotropin release and the consequent folliculogenesis/steroidogenesis. Notably, mutations in genes encoding kisspeptin (KISS1), kisspeptin receptor (GPR54), or NKB (TAC3) in humans, or deletion of these genes in rodents, cause hypogonadotropic hypogonadism. Therefore, cellular models of KNDy neurons are useful for elucidating the pathogenesis of reproductive disorders and for developing novel therapies for these disorders. Here, we established a method to differentiate KNDy neurons from mouse embryonic stem cells (mESCs).</p><p><strong>Methods: </strong>mESCs were incubated in culture medium containing agents that enhance Sonic Hedgehog signaling, a ventralizing signal, to induce the differentiation of ventral hypothalamic organoids. Kisspeptin-expressing cells were generated by adding a Notch inhibitor, dispersing the aggregates, and transferring them into a two-dimensional culture system. Kisspeptin-, NKB-, and Dyn-expressing cells were identified by immunohistochemistry, and kisspeptin secretion into the culture medium was quantified by enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Immunoreactivity for kisspeptin, NKB, and Dyn was detected in differentiated organoids derived from mESCs. Furthermore, kisspeptin secretion was evident in culture supernatants of differentiated KNDy neurons.</p><p><strong>Conclusions: </strong>This is the first report demonstrating the differentiation of KNDy neurons from pluripotent stem cells, which can be applied to create cellular models for various diseases caused by KNDy peptide deficiency and may contribute to the development of novel therapeutic approaches and understanding cellular mechanisms regulating mammalian reproduction.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNAH3 interacts with DNALI1 is required for sperm flagellum function and male fertility.","authors":"Qiuling Yue, Haoqiang Zhang, Bo Xu, Min Chen, Ao Ma, Junyi Li, Di Yan, Yifan Jiang, Baomei Qian, Ming Li, Limin Wu, Xiaozhi Zhao, Xiaohua Jiang, Shun Bai","doi":"10.1186/s12958-026-01538-9","DOIUrl":"https://doi.org/10.1186/s12958-026-01538-9","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal trends in sperm quality in Denmark and Florida.","authors":"Emilie Lassen, Allan A Pacey, Anne-Bine Skytte, Robert Montgomerie","doi":"10.1186/s12958-026-01537-w","DOIUrl":"https://doi.org/10.1186/s12958-026-01537-w","url":null,"abstract":"","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}