Synthesis, in silico studies, and in vitro biological evaluation of newly-designed 5-amino-1H-tetrazole-linked 5-fluorouracil analog as a potential antigastric-cancer agent

Javad Nowdehi, Elaheh Mosaddegh, Samad Khaksar, Masoud Torkzadeh-Mahani, Maria Beihaghi, Mohsen Yazdani
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Abstract

5-Fluorouracil (5FU) is a chemotherapy drug used to treat various cancers, such as colorectal, prostate, skin, pancreas, and stomach, as an ointment or solution. However, its consumption has severa...
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新设计的 5-amino-1H-tetrazole 链接 5-氟尿嘧啶类似物的合成、硅学研究和体外生物学评价,作为一种潜在的抗胃癌药物
5-氟尿嘧啶(5FU)是一种用于治疗结直肠癌、前列腺癌、皮肤癌、胰腺癌和胃癌等多种癌症的化疗药物,可制成软膏或溶液。然而,服用这种药物会对人体造成严重危害。
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