Demographic and clinical profile of 1106 adult soft tissue sarcoma patients: A single institutional prospective database experience from India

IF 1.4 4区医学 Q4 ONCOLOGY Asia-Pacific journal of clinical oncology Pub Date : 2024-02-21 DOI:10.1111/ajco.14050

Jyoti Sharma, Surya V. S Deo, Sunil Kumar, Sandeep Bhoriwal, Madhabananda Kar, Adarsh W Barwad, Sanjay Thulkar, Sameer Bakhshi, D. N. Sharma

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Abstract

Background

Adult soft tissue sarcomas (STS) are rare and diverse. Current management is based on limited literature from the West. Therefore, data from different geographical regions is required, including the low-middle-income countries. This is our experience managing adult sarcomas in the tertiary cancer center of North India.

Materials and methods

This is a retrospective analysis of the structured sarcoma database of patients treated in the surgical oncology department between 1992 and 2020. The descriptive analysis includes demography, site distribution, diagnosis, histopathology variations, prior surgical interventions, and stage.

Results

A total of 1106 soft tissue sarcoma patients were treated in three decades. Age distribution was 13%, 43%, 31%, and 11% in <20, 21–40, and 41–60 and >60 years, respectively. The male-to-female ratio was 1.73. The anatomical distribution was 17%, 42%, 23%, 7%, 7%, and 3% in upper extremity, lower extremity, trunk, retroperitoneum, head and neck, and viscera, respectively. Overall, 49% of patients had undergone prior suboptimal surgeries at community hospitals. Common histology subtypes were synovial sarcoma (18%), undifferentiated pleomorphic sarcoma (UPS) (13%), dermatofibrosarcoma protuberans (12%), and liposarcoma (9%). A pathological discordance of 13% was identified between the initial and the final histologies. Overall, 61% of tumors were high-grade. Memorial Sloan Kettering Stages II and III were present in 33% and 35% of patients, respectively.

Conclusions

This is one of the largest single institutional experiences of STS from the Asian population. Mostly young adults were affected with male preponderance. The lower extremity and trunk were common subsites. Frequent histologies were synovial sarcoma and UPS. A high rate of suboptimal surgical intervention at the community level and pathological discordance was noted. This study highlights the need to establish prospective structured databases for capturing quality information related to rare malignancies and providing insights for future research.

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1106名成人软组织肉瘤患者的人口统计学和临床概况：印度单一机构的前瞻性数据库经验。

背景：成人软组织肉瘤（STS）非常罕见，而且种类繁多。目前的治疗方法基于西方国家有限的文献。因此，需要来自不同地区的数据，包括中低收入国家。这是我们在北印度三级癌症中心治疗成人肉瘤的经验：这是对 1992 年至 2020 年期间在肿瘤外科接受治疗的患者的结构化肉瘤数据库进行的回顾性分析。描述性分析包括人口统计学、部位分布、诊断、组织病理学变化、之前的手术干预和分期：结果：三十年间共治疗了1106名软组织肉瘤患者。年龄分布为13%、43%、31%和11%（60岁以下）。男女比例为 1.73。上肢、下肢、躯干、腹膜后、头颈部和内脏的解剖分布分别为17%、42%、23%、7%、7%和3%。总体而言，49%的患者曾在社区医院接受过次优手术。常见的组织学亚型为滑膜肉瘤（18%）、未分化多形性肉瘤（UPS）（13%）、原发性皮纤维肉瘤（12%）和脂肪肉瘤（9%）。初始组织学和最终组织学之间的病理不一致率为 13%。总体而言，61%的肿瘤属于高级别。纪念斯隆-凯特琳癌症II期和III期患者分别占33%和35%：结论：这是亚洲人群中最大的单个机构STS病例之一。患者多为青壮年，男性居多。下肢和躯干是常见的亚部位。常见组织学为滑膜肉瘤和UPS。研究发现，在社区一级，手术干预不理想和病理不一致的比例很高。这项研究强调，有必要建立前瞻性结构数据库，以获取与罕见恶性肿瘤相关的高质量信息，并为今后的研究提供启示。

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来源期刊

Asia-Pacific journal of clinical oncology 医学-肿瘤学

CiteScore

3.40

自引率

0.00%

发文量

175

审稿时长

6-12 weeks

期刊介绍： Asia–Pacific Journal of Clinical Oncology is a multidisciplinary journal of oncology that aims to be a forum for facilitating collaboration and exchanging information on what is happening in different countries of the Asia–Pacific region in relation to cancer treatment and care. The Journal is ideally positioned to receive publications that deal with diversity in cancer behavior, management and outcome related to ethnic, cultural, economic and other differences between populations. In addition to original articles, the Journal publishes reviews, editorials, letters to the Editor and short communications. Case reports are generally not considered for publication, only exceptional papers in which Editors find extraordinary oncological value may be considered for review. The Journal encourages clinical studies, particularly prospectively designed clinical trials.