Characterization of HIV-1 subtypes and drug resistance mutations in Slovakia: update 2017-2018.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_26

Monika Habekova, Danica Valkovicova Stanekova, Maria Takacova, Alexandra Kovarova

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Abstract

Objectives: This study aimed to provide an overview on the HIV-1 subtypes circulating in Slovakia between 2017 and 2018 and to evaluate the risk of transmission of HIV‑resistant strains.

Background: The HIV epidemic in Slovakia is characterised by low incidence of new and pre-existing infections and a slightly elevated level of strain heterogeneity.

Methods: Partial HIV pol gene sequences of 110 individuals newly diagnosed with HIV between 2017 and 2018 were analysed.

Results: The genotypic analysis revealed sporadic occurrence of mutations linked to HIV resistance to antiretroviral therapy (ART). The HIV-1 B subtype has been found as predominant (84.55 %) and primarily linked to men who have sex with men (MSM). A total of eighteen individuals (15.45 %) were found to be infected with HIV-1 non-B subtypes.

Conclusion: The data suggest a minimal risk of a resistant HIV strain transmission and a marginal rise of HIV-1 subtypes´ diversity. The HIV-1 B subtype remains the most prevalent in the period 2017-2018 in Slovakia (Tab. 2, Fig. 2, Ref. 37).

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斯洛伐克 HIV-1 亚型和耐药性突变的特征：2017-2018 年更新。

研究目的本研究旨在概述2017年至2018年间在斯洛伐克流行的HIV-1亚型，并评估HIV耐药株的传播风险：斯洛伐克艾滋病疫情的特点是新感染者和原有感染者的发病率较低，菌株异质性略高：分析了2017年至2018年间110名新诊断为HIV感染者的部分HIV pol基因序列：基因型分析表明，零星出现的突变与艾滋病毒对抗逆转录病毒疗法（ART）的耐药性有关。发现HIV-1 B亚型占主导地位（84.55%），主要与男男性行为者（MSM）有关。共发现 18 人（15.45%）感染了 HIV-1 非 B 亚型：这些数据表明，耐药 HIV 株传播的风险很小，HIV-1 亚型的多样性略有上升。2017-2018年期间，HIV-1 B亚型仍是斯洛伐克最流行的病毒（表2，图2，参考文献37）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bratislava Medical Journal-Bratislavske Lekarske Listy 医学-医学：内科

CiteScore

2.60

自引率

0.00%

发文量

185

审稿时长

3-8 weeks

期刊介绍： The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.