Serological screening for celiac disease, by endomysial antibodies, in patients with rheumatoid arthritis.

Mariam Ghozzi, Fatma Mechi, Alma Ben Salem, Ikram El Ahmer, Donia Rachel Mbarki, Sarra Melayah, Amani Mankai, Ibtissem Ghedira
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Abstract

Celiac disease (CD) and rheumathoid arthritis (RA) are both multi-factorial chronic inflammatory auto-immune diseases. In this retrospective study, we determined the frequency of CD in patients with RA using IgA anti-endomysial antibodies (EmA) and tried to explain this association. Indirect immunofluorescence on human umbilical cord was used to detect EmA in 215 patients with seropositive RA collected over a 4-year-period. Two thousand and five hundred healthy blood donors (HBD) served as control group. Among the 215 patients with RA, 12 (9 females) were found positive for EmA while only 7 were positive for EmA in control group, EmA are significantly more frequent in RA patients than in HBD (5.58% vs. 0.28%, p < 10-6; 95% CI [8.21-54.01]; odds ratio: 21.05). In RA patients, the frequency of EmA was not statistically different between males and females. The frequency of EmA was significantly higher in female patients than in healthy females (5.32% vs. 0.40%, p < 10-3). Patients with RA can be considered as a high-risk group for CD based on the high frequency of EmA positivity observed in our study.

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通过类风湿性关节炎患者的内膜抗体进行乳糜泻血清学筛查。
乳糜泻(CD)和类风湿性关节炎(RA)都是多因素慢性自身免疫炎症性疾病。在这项回顾性研究中,我们利用 IgA 抗内膜抗体(EmA)确定了 RA 患者中 CD 的发病频率,并试图解释这种关联。我们用间接免疫荧光法检测了 215 名血清反应阳性 RA 患者脐带中的 EmA,采集时间长达 4 年。2,500 名健康献血者(HBD)作为对照组。在 215 名 RA 患者中,有 12 人(9 名女性)发现 EmA 阳性,而对照组中只有 7 人发现 EmA 阳性。
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