Electromembrane extraction of peptides – Looking retrospectively into published studies

IF 5.2 Q1 CHEMISTRY, ANALYTICAL Advances in Sample Preparation Pub Date : 2024-02-01 DOI:10.1016/j.sampre.2024.100106

Torstein Kige Rye , Samira Dowlatshah , Frederik André Hansen , Trine Grønhaug Halvorsen , Stig Pedersen-Bjergaard

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Abstract

Electromembrane extraction (EME) has been developed into an attractive microextraction concept for extraction of pharmaceuticals and related substances from blood and urine. In EME, charged substances are extracted across a liquid membrane (organic) under the influence of an electrical field. Recently, commercial equipment for EME was launched, and this is expected to increase the interest for the technique. EME has also been explored for extraction of peptides, but this is more complicated due to the challenges related to the solvation of peptides in the organic liquid membrane. In this paper, we review the literature on EME of peptides, and we retrospectively look closer into published studies based on our current understanding of the concept. By such, we can explain early observations in more detail, and we can improve our fundamental understanding.

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多肽的电膜提取--回顾已发表的研究成果

电膜萃取（EME）已发展成为一种极具吸引力的微萃取概念，用于从血液和尿液中萃取药物和相关物质。在 EME 中，带电物质在电场的影响下穿过液膜（有机物）被萃取出来。最近，用于 EME 的商业设备已经推出，预计这将提高人们对这项技术的兴趣。EME 也被用于肽的萃取，但由于肽在有机液膜中的溶解问题，这项技术更为复杂。在本文中，我们回顾了有关多肽 EME 的文献，并根据我们目前对这一概念的理解，对已发表的研究进行了回顾性研究。通过这些研究，我们可以更详细地解释早期的观察结果，并提高我们对这一概念的基本认识。

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来源期刊

Advances in Sample Preparation

CiteScore

3.50

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0.00%

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