A 3-mV Precision Dual-Mode-Controlled Fast Charge Balancing for Implantable Biphasic Neural Stimulators

Kai Cui;Yaxue Jin;Xiaoya Fan;Yanzhao Ma
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Abstract

This paper 5 presents a novel charge balancing (CB) with a current-control (CC) mode and a voltage-control (VC) mode for implantable biphasic stimulators, which can achieve one-step accurate anodic pulse generating. Compared with the conventional short-pulse-injection-based CB, the proposed method could reduce the balancing time and avoid inducing undesired artifact. The CC operation compensates the majority stimulation charge at high speed, while the VC operation guarantees a high CB precision. In order to eliminate the oscillation during the mode transition, a smooth CC-VC transition method is adopted. In addition, a digital auxiliary monitoring loop is introduced against the variations of the tissue-electrode interface impedance during the stimulation process to meet long-term CB requirement. The proposed stimulator has been fabricated in a 0.18 μm BCD process with 10 V voltage compliance, and the measured CB precision is less than 3 mV. The functionalities of the proposed CB have been verified successfully through in vitro experiments.
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用于植入式双相神经刺激器的 3 毫伏精密双模控制快速充电平衡器。
本文提出了一种新型电荷平衡(CB)方法,它具有电流控制(CC)模式和电压控制(VC)模式,适用于植入式双相刺激器,可实现一步式精确阳极脉冲生成。与传统的基于短脉冲注入的 CB 相比,所提出的方法可以缩短平衡时间,避免诱发不良伪像。CC 操作能高速补偿大部分刺激电荷,而 VC 操作则能保证高的 CB 精度。为了消除模式转换过程中的振荡,采用了平滑的 CC-VC 转换方法。此外,针对刺激过程中组织-电极界面阻抗的变化,还引入了数字辅助监测回路,以满足长期的 CB 要求。所提出的刺激器采用 0.18 μm BCD 工艺制造,电压符合 10 V 标准,所测得的 CB 精度小于 3 mV。体外实验成功验证了所提出的 CB 的功能。
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