Visible-light-promoted tandem decarboxylation coupling/cyclization of N-aryl glycines with quinoxalinones: Easy access to tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones
{"title":"Visible-light-promoted tandem decarboxylation coupling/cyclization of N-aryl glycines with quinoxalinones: Easy access to tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones","authors":"Zhen Tang, Chao Pi, Yangjie Wu, Xiuling Cui","doi":"10.1016/j.gresc.2022.10.001","DOIUrl":null,"url":null,"abstract":"<div><p>A visible-light-promoted formal [2 + 2 + 1] cyclization of <em>N</em>-aryl glycines with quinoxalin-2(1<em>H</em>)-ones to synthesize tetrahydroimidazo[1,5-<em>a</em>]quinoxalin-4(5<em>H</em>)-ones have been developed. The protocol features operational simplicity, mild reaction conditions with blue LED light employing Ru(bpy)<sub>3</sub>Cl<sub>2</sub><sup>.</sup>6H<sub>2</sub>O as a photoredox catalyst, a combination of O<sub>2</sub> from air and Cu(OAc)<sub>2</sub> as the oxidant and broad substrate applicability.</p></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"5 1","pages":"Pages 31-34"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666554922001004/pdfft?md5=8255ec7eec8de00b3538ee29cf98d646&pid=1-s2.0-S2666554922001004-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Synthesis and Catalysis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666554922001004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A visible-light-promoted formal [2 + 2 + 1] cyclization of N-aryl glycines with quinoxalin-2(1H)-ones to synthesize tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones have been developed. The protocol features operational simplicity, mild reaction conditions with blue LED light employing Ru(bpy)3Cl2.6H2O as a photoredox catalyst, a combination of O2 from air and Cu(OAc)2 as the oxidant and broad substrate applicability.
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