Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2024.05.003
Linfeng Liu , Yujian Pang , Canliang Ma , Daiqing Zhou , Wenjie Zhang , Jin Huang , Jie Sun , Jiangkai Qiu , Yihuan Liu , Lei Shen , Zhenjiang Li , Kai Guo
While C(sp3)-S bonds exist in many biologically active compounds, the direct catalytic C(sp3)-H thiolation remains elusive. Herein, we report a convenient and green C(sp3)-H thiolation approach mediated by using tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst. A wide range of C(sp3)-H bond-containing etheric, allylic, alkyl, ketonic, amidic substrates and sulfonyl-based SOMOphiles participated in the reaction, producing thioethers with high efficiency. The present protocol features green characteristics, such as being free of harmful oxidants and additives; step-economic; redox-neutral; and amenable to scale-up assisted by continuous-flow technology.
{"title":"Direct C(sp3)-H functionalization with thiosulfonates via photoredox catalysis","authors":"Linfeng Liu , Yujian Pang , Canliang Ma , Daiqing Zhou , Wenjie Zhang , Jin Huang , Jie Sun , Jiangkai Qiu , Yihuan Liu , Lei Shen , Zhenjiang Li , Kai Guo","doi":"10.1016/j.gresc.2024.05.003","DOIUrl":"10.1016/j.gresc.2024.05.003","url":null,"abstract":"<div><div>While C(sp<sup>3</sup>)-S bonds exist in many biologically active compounds, the direct catalytic C(sp<sup>3</sup>)-H thiolation remains elusive. Herein, we report a convenient and green C(sp<sup>3</sup>)-H thiolation approach mediated by using tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst. A wide range of C(sp<sup>3</sup>)-H bond-containing etheric, allylic, alkyl, ketonic, amidic substrates and sulfonyl-based SOMOphiles participated in the reaction, producing thioethers with high efficiency. The present protocol features green characteristics, such as being free of harmful oxidants and additives; step-economic; redox-neutral; and amenable to scale-up assisted by continuous-flow technology.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 453-458"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2024.05.008
Kaili Cen , Mixia Ouyang , Guojun He , Zhouting Zeng , Qiaolin Wang , Xin Yu , Feng Zhao , Jinhui Cai
An electrocatalytic 3,3-rearrangement/cyclization approach has been developed for the transformation of aryl-substituted propargylic aryl ethers to naphtho[1,2-b]furan-2-carbaldehyde and naphtho[2,1-b]furan-2-carbaldehyde derivatives. The reaction proceeded efficiently under mild conditions in the absence of metal- and chemical-oxidant, yielding the desired products with good substrate scope and functional group tolerance via a radical pathway. Furthermore, the control experiment revealed that the phenylselenyl-substituted secondary alcohol might be intermediate, and the 18O labeling reaction indicated the oxygen source in the product possibly deriving from water. Significantly, further transformations of the product were conducted to showcase the utility of this electrosynthesis strategy.
{"title":"Synthesis of naphtho[1,2-b]furan-2-carbaldehydes and naphtho[2,1-b]furan-2-carbaldehydes via electrocatalytic 3,3-rearrangement/cyclization of propargylic aryl ethers under mild conditions","authors":"Kaili Cen , Mixia Ouyang , Guojun He , Zhouting Zeng , Qiaolin Wang , Xin Yu , Feng Zhao , Jinhui Cai","doi":"10.1016/j.gresc.2024.05.008","DOIUrl":"10.1016/j.gresc.2024.05.008","url":null,"abstract":"<div><div>An electrocatalytic 3,3-rearrangement/cyclization approach has been developed for the transformation of aryl-substituted propargylic aryl ethers to naphtho[1,2-<em>b</em>]furan-2-carbaldehyde and naphtho[2,1-<em>b</em>]furan-2-carbaldehyde derivatives. The reaction proceeded efficiently under mild conditions in the absence of metal- and chemical-oxidant, yielding the desired products with good substrate scope and functional group tolerance <em>via</em> a radical pathway. Furthermore, the control experiment revealed that the phenylselenyl-substituted secondary alcohol might be intermediate, and the <sup>18</sup>O labeling reaction indicated the oxygen source in the product possibly deriving from water. Significantly, further transformations of the product were conducted to showcase the utility of this electrosynthesis strategy.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 444-448"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141281817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2024.03.003
Yiman Cui, Yadong Gao, Licheng Yang
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts, have emerged as green, efficient, and highly selective solutions for substrates containing ketones or aldehydes, demonstrating exceptional performance in the synthesis of active drug molecules and natural products. This review primarily centers on the application of transaminases in the synthesis of important drug molecules bearing chiral amine group on acyclic or cyclic backbones. We delve into specific examples, highlighting the catalytic prowess of the sole transaminase catalyst as well as the combination with other enzymes in cascade transformations. This review illustrates the primary challenges that transaminases face and provides practical solutions that have been developed in these contexts. These solutions encompass various strategies and techniques that enhance the applicability and efficiency of transaminase-catalyzed reactions. In closing, we offer an outlook on the future of transaminase applications, discussing potential developments and emerging areas where this green and selective catalysis may play a pivotal role.
{"title":"Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients","authors":"Yiman Cui, Yadong Gao, Licheng Yang","doi":"10.1016/j.gresc.2024.03.003","DOIUrl":"10.1016/j.gresc.2024.03.003","url":null,"abstract":"<div><div>Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts, have emerged as green, efficient, and highly selective solutions for substrates containing ketones or aldehydes, demonstrating exceptional performance in the synthesis of active drug molecules and natural products. This review primarily centers on the application of transaminases in the synthesis of important drug molecules bearing chiral amine group on acyclic or cyclic backbones. We delve into specific examples, highlighting the catalytic prowess of the sole transaminase catalyst as well as the combination with other enzymes in cascade transformations. This review illustrates the primary challenges that transaminases face and provides practical solutions that have been developed in these contexts. These solutions encompass various strategies and techniques that enhance the applicability and efficiency of transaminase-catalyzed reactions. In closing, we offer an outlook on the future of transaminase applications, discussing potential developments and emerging areas where this green and selective catalysis may play a pivotal role.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 359-378"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140148130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2023.12.004
Hong Qin , Man Yang , Yuguang Li , Xiaobing Yang , Yujing Hu , Chengkou Liu , Wei He , Zheng Fang , Kai Guo
The first regioselective [4 + 2] annulation reactions of quinone monoacetals with isothiocyanates and Na2S have been accomplished. This convenient and novel protocol involves the synthesis of valuable bridged thiazine-2-thione and thiazole-2-thiones through DBU-promoted at room temperature. Mechanism study reveals the dearomative transformation possibly undergoes a radical cascade reaction on the structure of quinone monoacetals to an efficient synthesis of a broad range of thione-containing heterocyclic compounds with broad tolerance in moderate to excellent yields. Moreover, the reported procedure can be easily applied to a 1g scale.
{"title":"Synthesis of bridged bicyclic thiazine-2-thione and thiazole-2-thiones through DBU-promoted regioselective annulation of quinone monoacetals under mild conditions","authors":"Hong Qin , Man Yang , Yuguang Li , Xiaobing Yang , Yujing Hu , Chengkou Liu , Wei He , Zheng Fang , Kai Guo","doi":"10.1016/j.gresc.2023.12.004","DOIUrl":"10.1016/j.gresc.2023.12.004","url":null,"abstract":"<div><div>The first regioselective [4 + 2] annulation reactions of quinone monoacetals with isothiocyanates and Na<sub>2</sub>S have been accomplished. This convenient and novel protocol involves the synthesis of valuable bridged thiazine-2-thione and thiazole-2-thiones through DBU-promoted at room temperature. Mechanism study reveals the dearomative transformation possibly undergoes a radical cascade reaction on the structure of quinone monoacetals to an efficient synthesis of a broad range of thione-containing heterocyclic compounds with broad tolerance in moderate to excellent yields. Moreover, the reported procedure can be easily applied to a 1g scale.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 399-403"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139946967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2024.06.002
Li Yang , Priyanka Chakraborty , Pradip K. Das, Dongya Zhang, Kuo-Wei Huang
The atom-economical reaction of carbon dioxide (CO2) with epoxides possesses the potential to utilize captured CO₂ for synthesizing useful chemicals. Among a wide range of metal complexes employed for this transformation, iron (Fe) stands out because of its low cost, ready availability, and stability. In this work, a pyridine-based pincer PN³-Fe(II) complex was synthesized and used as an efficient catalyst for the CO₂ epoxide cycloaddition. More importantly, this complex enabled the direct capture of CO₂ in the atmosphere and conversion into cyclic carbonates in excellent yields.
{"title":"Transformation of ambient CO2 in air into cyclic carbonates mediated by a phosphorus-nitrogen PN3-pincer iron complex","authors":"Li Yang , Priyanka Chakraborty , Pradip K. Das, Dongya Zhang, Kuo-Wei Huang","doi":"10.1016/j.gresc.2024.06.002","DOIUrl":"10.1016/j.gresc.2024.06.002","url":null,"abstract":"<div><div>The atom-economical reaction of carbon dioxide (CO<sub>2</sub>) with epoxides possesses the potential to utilize captured CO₂ for synthesizing useful chemicals. Among a wide range of metal complexes employed for this transformation, iron (Fe) stands out because of its low cost, ready availability, and stability. In this work, a pyridine-based pincer PN³-Fe(II) complex was synthesized and used as an efficient catalyst for the CO₂ epoxide cycloaddition. More importantly, this complex enabled the direct capture of CO₂ in the atmosphere and conversion into cyclic carbonates in excellent yields.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 435-438"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141885090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2024.06.003
Feiyu Qiu , Yi Chen , Peiqin Liao, Yuan Gao, Mian Guo, Heng Zhang, Aiwen Lei, Wu Li
Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an electrochemical selective deuterium labelling of N-heteroarenes using D2O. The formation of aromatic radicals has been directly identified by using the time-resolved electron paramagnetic resonance (EPR) technique under electrochemical conditions. Mechanistic studies revealed that the hydrogen/deuterium (H/D) exchange involved continuous redox of N-heteroarenes under paired electrolysis and the selectivity of deuteration was established by DFT calculations. This electrochemical synthesis method offers a promising avenue for deuterium incorporation at specific sites of aromatic compounds.
氢氘交换（HIE）反应是实现氘标记的最直接方法，因为它不需要额外的预官能化。在此，我们报告了一种利用 DO 对-heteroarenes 进行电化学选择性氘标记的方法。在电化学条件下，利用时间分辨电子顺磁共振（EPR）技术直接确定了芳香族自由基的形成。机理研究表明，在成对电解条件下，氢/氘（H/D）交换参与了-heteroarenes 的连续氧化还原，并通过 DFT 计算确定了氘化的选择性。这种电化学合成方法为在芳香族化合物的特定位点掺入氘提供了一种前景广阔的途径。
{"title":"Electrochemical selective deuterium labelling of N-heteroarenes","authors":"Feiyu Qiu , Yi Chen , Peiqin Liao, Yuan Gao, Mian Guo, Heng Zhang, Aiwen Lei, Wu Li","doi":"10.1016/j.gresc.2024.06.003","DOIUrl":"10.1016/j.gresc.2024.06.003","url":null,"abstract":"<div><div>Hydrogen-deuterium exchange (HIE) reaction is the most direct way to achieve the deuterium labeling as there is no need for extra pre-functionalization. Herein, we report an electrochemical selective deuterium labelling of <em>N</em>-heteroarenes using D<sub>2</sub>O. The formation of aromatic radicals has been directly identified by using the time-resolved electron paramagnetic resonance (EPR) technique under electrochemical conditions. Mechanistic studies revealed that the hydrogen/deuterium (H/D) exchange involved continuous redox of <em>N</em>-heteroarenes under paired electrolysis and the selectivity of deuteration was established by DFT calculations. This electrochemical synthesis method offers a promising avenue for deuterium incorporation at specific sites of aromatic compounds.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 439-443"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2024.08.006
Xiao-Qi Zhang , Hui-Jie Wang , Hui Jiang, Mao-Ping Song, Jun-Fang Gong
Readily prepared chiral bis(imidazoline) NCN pincer iridium(III) complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes to trifluoropyruvates. With a catalyst loading of 5 mol%, a variety of optically active α-trifluoromethylated tertiary propargylic alcohols were thus produced in good yields with high enantioselectivity (27 examples, 74%–96% ee). Both enantiomers of the catalysis products were obtained by using enantiomeric Ir(III) catalysts. In addition, gram scale synthesis of the product and its transformation to a potentially very useful 2H-1,2,3-triazole compound were accomplished. Control experiments suggested that the alkynylide Ir(III) intermediates were involved in the reactions.
{"title":"Chiral bis(imidazoline) NCN pincer iridium(III)-catalyzed enantioselective alkynylation of trifluoropyruvates with terminal alkynes","authors":"Xiao-Qi Zhang , Hui-Jie Wang , Hui Jiang, Mao-Ping Song, Jun-Fang Gong","doi":"10.1016/j.gresc.2024.08.006","DOIUrl":"10.1016/j.gresc.2024.08.006","url":null,"abstract":"<div><div>Readily prepared chiral bis(imidazoline) NCN pincer iridium(III) complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes to trifluoropyruvates. With a catalyst loading of 5 mol%, a variety of optically active <em>α</em>-trifluoromethylated tertiary propargylic alcohols were thus produced in good yields with high enantioselectivity (27 examples, 74%–96% <em>ee</em>). Both enantiomers of the catalysis products were obtained by using enantiomeric Ir(III) catalysts. In addition, gram scale synthesis of the product and its transformation to a potentially very useful 2<em>H</em>-1,2,3-triazole compound were accomplished. Control experiments suggested that the alkynylide Ir(III) intermediates were involved in the reactions.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 429-434"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2024.11.005
Sufang Shao , Zhi-Peng Bao , Xiao-Feng Wu
In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic modes. Among the carbonylation reactions, non-activated bulky alkyl halides and highly reactive thiol compounds are considered to be particularly challenging substrates. In this study, we studied the synthesis of various steric alkyl thioesters through the reaction of non-activated steric alkyl iodides with S-aryl thioester as the aryl sulfur source catalyzed by iron salt. This reaction offers a convenient approach for the synthesis of hindered thioesters. Preliminary mechanistic studies indicated the involvement of radical intermediates.
{"title":"Iron-catalyzed carbonylative synthesis of tert-alkyl thioesters","authors":"Sufang Shao , Zhi-Peng Bao , Xiao-Feng Wu","doi":"10.1016/j.gresc.2024.11.005","DOIUrl":"10.1016/j.gresc.2024.11.005","url":null,"abstract":"<div><div>In the context of transition metal-catalyzed carbonylation reactions, iron-catalyzed carbonylative transformation retains considerable value due to its high abundance, affordability, and diverse catalytic modes. Among the carbonylation reactions, non-activated bulky alkyl halides and highly reactive thiol compounds are considered to be particularly challenging substrates. In this study, we studied the synthesis of various steric alkyl thioesters through the reaction of non-activated steric alkyl iodides with <em>S</em>-aryl thioester as the aryl sulfur source catalyzed by iron salt. This reaction offers a convenient approach for the synthesis of hindered thioesters. Preliminary mechanistic studies indicated the involvement of radical intermediates.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 449-452"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2025.06.001
Houzong Yao , Xianjing Zheng , Minjie Liu , Yuelun Xu , Ping Xu , Fen-Er Chen
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments, substantial gaps remain in the management of chronic infections, particularly in regions like China, where millions are affected. This review delves into the synthesis of clinical anti-HBV drugs, including lamivudine, adefovir, tenofovir, entecavir, and telbivudine, highlighting various synthetic strategies. By emphasizing efficient synthetic routes suitable for large-scale production, this review contributes valuable insights for enhancing treatment accessibility and improving patient outcomes in hepatitis B management.
{"title":"Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review","authors":"Houzong Yao , Xianjing Zheng , Minjie Liu , Yuelun Xu , Ping Xu , Fen-Er Chen","doi":"10.1016/j.gresc.2025.06.001","DOIUrl":"10.1016/j.gresc.2025.06.001","url":null,"abstract":"<div><div>Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments, substantial gaps remain in the management of chronic infections, particularly in regions like China, where millions are affected. This review delves into the synthesis of clinical anti-HBV drugs, including lamivudine, adefovir, tenofovir, entecavir, and telbivudine, highlighting various synthetic strategies. By emphasizing efficient synthetic routes suitable for large-scale production, this review contributes valuable insights for enhancing treatment accessibility and improving patient outcomes in hepatitis B management.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 339-358"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.gresc.2025.04.001
Victoria S. Zhuravleva , Anastasiya A. Shesterkina , Anna A. Strekalova , Kseniia V. Vikanova , Alexander L. Kustov
Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural – a product of biomass catalytic conversion – is a well-known “platform” molecule, a starting material for the obtaining of a number of important chemical substances. Nowadays, the focus of the researchers is directed to the search for a suitable catalytic system for effective conversion of furfural. In this review, the recent advances in the development of Ni-based mono- and bimetallic catalytic systems for furfural hydrogenation as an alternative to the industrial toxic copper chromite catalyst were considered. Special attention was paid to the study of the catalytic properties of bimetallic Ni-Me (second metal) catalytic systems, as well as a detailed discussion of the mechanisms of furfural hydrogenation.
{"title":"Recent progress in selective liquid-phase hydrogenation of furfural on heterogeneous Ni-containing catalysts","authors":"Victoria S. Zhuravleva , Anastasiya A. Shesterkina , Anna A. Strekalova , Kseniia V. Vikanova , Alexander L. Kustov","doi":"10.1016/j.gresc.2025.04.001","DOIUrl":"10.1016/j.gresc.2025.04.001","url":null,"abstract":"<div><div>Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural – a product of biomass catalytic conversion – is a well-known “platform” molecule, a starting material for the obtaining of a number of important chemical substances. Nowadays, the focus of the researchers is directed to the search for a suitable catalytic system for effective conversion of furfural. In this review, the recent advances in the development of Ni-based mono- and bimetallic catalytic systems for furfural hydrogenation as an alternative to the industrial toxic copper chromite catalyst were considered. Special attention was paid to the study of the catalytic properties of bimetallic Ni-Me (second metal) catalytic systems, as well as a detailed discussion of the mechanisms of furfural hydrogenation.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 4","pages":"Pages 379-386"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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