Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia.

IF 5.3 1区 医学 Q1 PSYCHIATRY Schizophrenia Bulletin Pub Date : 2024-11-08 DOI:10.1093/schbul/sbae020
Fan Mo, Han Zhao, Yifan Li, Huanhuan Cai, Yang Song, Rui Wang, Yongqiang Yu, Jiajia Zhu
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Abstract

Background and hypothesis: Neuroimaging studies investigating the neural substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed results, which may be reconciled by network localization. We sought to examine whether AVH-state and AVH-trait brain alterations in schizophrenia localize to common or distinct networks.

Study design: We initially identified AVH-state and AVH-trait brain alterations in schizophrenia reported in 48 previous studies. By integrating these affected brain locations with large-scale discovery and validation resting-state functional magnetic resonance imaging datasets, we then leveraged novel functional connectivity network mapping to construct AVH-state and AVH-trait dysfunctional networks.

Study results: The neuroanatomically heterogeneous AVH-state and AVH-trait brain alterations in schizophrenia localized to distinct and specific networks. The AVH-state dysfunctional network comprised a broadly distributed set of brain regions mainly involving the auditory, salience, basal ganglia, language, and sensorimotor networks. Contrastingly, the AVH-trait dysfunctional network manifested as a pattern of circumscribed brain regions principally implicating the caudate and inferior frontal gyrus. Additionally, the AVH-state dysfunctional network aligned with the neuromodulation targets for effective treatment of AVH, indicating possible clinical relevance.

Conclusions: Apart from unifying the seemingly irreproducible neuroimaging results across prior AVH studies, our findings suggest different neural mechanisms underlying AVH state and trait in schizophrenia from a network perspective and more broadly may inform future neuromodulation treatment for AVH.

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精神分裂症患者听觉言语幻觉的状态和特质的网络定位。
背景与假设:调查精神分裂症患者听觉言语幻觉(AVH)神经基底的神经影像学研究结果不一,这可能需要通过网络定位来调和。我们试图研究精神分裂症患者的听觉言语幻觉状态和听觉言语幻觉特质的大脑改变是否定位在共同或不同的网络中:研究设计:我们初步确定了先前 48 项研究中报道的精神分裂症患者的 AVH 状态和 AVH 特质脑部改变。通过将这些受影响的大脑位置与大规模发现和验证的静息态功能磁共振成像数据集进行整合,我们利用新型功能连接网络图构建了 AVH 状态和 AVH 特质功能障碍网络:研究结果:精神分裂症患者的神经解剖异质性AVH状态和AVH-特质脑改变被定位到不同的特定网络中。AVH状态的功能障碍网络包括一组广泛分布的脑区,主要涉及听觉、显著性、基底神经节、语言和感觉运动网络。与此形成鲜明对比的是,AVH-特质功能障碍网络则表现为主要涉及尾状回和额叶下回的环形脑区模式。此外,AVH 状态下的功能障碍网络与有效治疗 AVH 的神经调控目标一致,表明可能具有临床意义:我们的研究结果不仅统一了之前的 AVH 研究中看似不可再现的神经影像学结果,还从网络角度提出了精神分裂症患者 AVH 状态和特质的不同神经机制,更广泛地说,可为未来的 AVH 神经调控治疗提供参考。
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来源期刊
Schizophrenia Bulletin
Schizophrenia Bulletin 医学-精神病学
CiteScore
11.40
自引率
6.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.
期刊最新文献
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