Aging and sex are associated with multiple sleep latency test findings and their relationship with self-reported sleepiness

IF 1 4区医学 Q4 CLINICAL NEUROLOGY Sleep and Biological Rhythms Pub Date : 2024-02-25 DOI:10.1007/s41105-024-00512-5

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Abstract

The aim of this study was to assess age- and sex-related differences in multiple sleep latency test (MSLT) results and in the performance of the Epworth Sleepiness Scale (ESS) at classifying objective hypersomnia (mean sleep latency (MSL) ≤ 8 min). We studied 480 consecutive adults (39.3 ± 15.3 years old [18–93], 67.7% female) who underwent hypersomnia evaluation. We fit linear regression models to investigate associations between age and sex and sleep latencies (mean and for every nap), after adjusting for total sleep time and sleep efficiency (on polysomnography), and REM-suppressing antidepressant effect. A logistic regression was performed to assess whether age and sex were associated with sleep-onset REM period (SOREMP) occurrence. ROC analysis assessed the diagnostic performance of ESS scores to identify a MSL ≤ 8 min in different age/sex groups. For every 10 years of age, there was 0.41 (95% CI 0.11–0.72, p = 0.008) min reduction in MSL. Objectively (MSL ≤ 8 min) sleepy patients had shortening of latencies in naps 4 and 5 with aging. Female sex was associated with a higher MSL only in patients with MSL > 8 min. A 2.4% reduction in the odds of SOREMP occurrence was observed for every year of age in objectively sleepy patients (p = 0.045). ESS scores had a better diagnostic performance in older (≥ 50 years old) men than younger (< 50 years old) women (p < 0.05). Older patients with objectively confirmed hypersomnia may be sleepier in later naps, possibly due to less restorative naps and/or circadian rhythm factors. Self-reported sleepiness is more predictive of objective sleepiness in older men than younger women.

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年龄和性别与多重睡眠潜伏期测试结果及其与自我报告嗜睡程度的关系有关

摘要本研究旨在评估多重睡眠潜伏期测试（MSLT）结果和埃普沃思嗜睡量表（ESS）在客观嗜睡症（平均睡眠潜伏期（MSL）≤ 8 分钟）分级方面的年龄和性别差异。我们对连续接受嗜睡症评估的 480 名成年人（39.3 ± 15.3 岁 [18-93]，67.7% 为女性）进行了研究。在对总睡眠时间和睡眠效率（多导睡眠图）以及快速眼动抑制抗抑郁药效果进行调整后，我们建立了线性回归模型，以研究年龄和性别与睡眠潜伏期（平均值和每次小睡的潜伏期）之间的关系。为了评估年龄和性别是否与睡眠期快速动眼期（SOREMP）的发生有关，进行了逻辑回归。ROC分析评估了ESS评分在不同年龄/性别组中识别MSL≤8分钟的诊断性能。年龄每增加 10 岁，MSL 就会减少 0.41 分钟（95% CI 0.11-0.72, p = 0.008）。客观上（MSL ≤ 8 分钟），随着年龄的增长，嗜睡患者第 4 次和第 5 次小睡的潜伏期缩短。只有MSL大于8分钟的患者的MSL才与女性性别有关。客观嗜睡患者的年龄每增加一岁，发生 SOREMP 的几率就会降低 2.4%（p = 0.045）。老年男性（≥ 50 岁）的ESS 评分比年轻女性（50 岁）的ESS 评分具有更好的诊断性能（p < 0.05）。被客观证实患有嗜睡症的老年患者可能在晚睡时更容易入睡，这可能是由于恢复性小睡较少和/或昼夜节律因素造成的。与年轻女性相比，老年男性自我报告的嗜睡情况更能预测客观嗜睡情况。

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来源期刊

Sleep and Biological Rhythms 医学-临床神经学

CiteScore

2.20

自引率

9.10%

发文量

审稿时长

>12 weeks

期刊介绍： Sleep and Biological Rhythms is a quarterly peer-reviewed publication dealing with medical treatments relating to sleep. The journal publishies original articles, short papers, commentaries and the occasional reviews. In scope the journal covers mechanisms of sleep and wakefullness from the ranging perspectives of basic science, medicine, dentistry, pharmacology, psychology, engineering, public health and related branches of the social sciences