Using data on biomarkers and siblings to study early-life economic determinants of type-2 diabetes

IF 2 3区 医学 Q2 ECONOMICS Health economics Pub Date : 2024-02-25 DOI:10.1002/hec.4815
Rob J. M. Alessie, Viola Angelini, Gerard J. van den Berg, Jochen O. Mierau, Gianmaria Niccodemi
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Abstract

We study the effect of economic conditions early in life on the occurrence of type-2 diabetes in adulthood using contextual economic indicators and within-sibling pair variation. We use data from Lifelines: a longitudinal cohort study and biobank including 51,270 siblings born in the Netherlands from 1950 onward. Sibling fixed-effects account for selective fertility. To identify type-2 diabetes we use biomarkers on the hemoglobin A1c concentration and fasting glucose in the blood. We find that adverse economic conditions around birth increase the probability of type-2 diabetes later in life both in males and in females. Inference based on self-reported diabetes leads to biased results, incorrectly suggesting the absence of an effect. The same applies to inference that does not account for selective fertility.

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利用生物标志物和兄弟姐妹的数据研究 2 型糖尿病的早期经济决定因素
我们利用背景经济指标和兄弟姐妹内部的配对变异,研究了生命早期的经济条件对成年后 2 型糖尿病发生的影响。我们使用的数据来自 "生命线":一项纵向队列研究和生物数据库,其中包括 1950 年以来在荷兰出生的 51,270 对兄弟姐妹。兄弟姐妹固定效应考虑了选择性生育。为了识别 2 型糖尿病,我们使用了血红蛋白 A1c 浓度和空腹血糖的生物标志物。我们发现,出生时的不利经济条件会增加男性和女性日后患上 2 型糖尿病的概率。基于自我报告的糖尿病推断会导致结果偏差,错误地认为不存在影响。不考虑选择性生育的推论也是如此。
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来源期刊
Health economics
Health economics 医学-卫生保健
CiteScore
3.60
自引率
4.80%
发文量
177
审稿时长
4-8 weeks
期刊介绍: This Journal publishes articles on all aspects of health economics: theoretical contributions, empirical studies and analyses of health policy from the economic perspective. Its scope includes the determinants of health and its definition and valuation, as well as the demand for and supply of health care; planning and market mechanisms; micro-economic evaluation of individual procedures and treatments; and evaluation of the performance of health care systems. Contributions should typically be original and innovative. As a rule, the Journal does not include routine applications of cost-effectiveness analysis, discrete choice experiments and costing analyses. Editorials are regular features, these should be concise and topical. Occasionally commissioned reviews are published and special issues bring together contributions on a single topic. Health Economics Letters facilitate rapid exchange of views on topical issues. Contributions related to problems in both developed and developing countries are welcome.
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