Cytomegalovirus immunoglobulin serology prevalence in patients with newly diagnosed multiple myeloma treated within the GMMG-MM5 phase III trial.

IF 2 4区医学 Q3 HEMATOLOGY Hematology Pub Date : 2024-12-01 Epub Date: 2024-02-26 DOI:10.1080/16078454.2024.2320006

Hans Salwender, Niels Weinhold, Axel Benner, Kaya Miah, Maximilian Merz, Mathias Haenel, Christian Jehn, Elias Mai, Ekaterina Menis, Igor Blau, Christof Scheid, Dirk Hose, Anja Seckinger, Steffen Luntz, Britta Besemer, Markus Munder, Peter Brossart, Bertram Glass, Hans-Walter Lindemann, Katja Weisel, Christine Hanoun, Paul Schnitzler, Sarah Klemm, Hartmut Goldschmidt, Marc Raab, Ahmet Elmaagacli

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Abstract

Objectives: The seroprevalence of antibodies against Cytomegalovirus (CMV) is an established poor prognostic factor for patients receiving an allogeneic stem cell transplantation. However, the impact of CMV serology on outcome after autologous stem cell transplantation remains unknown.

Methods: Here, we analyzed the CMV immunoglobulin (Ig) serology of 446 newly-diagnosed multiple myeloma (MM) patients of the GMMG-MM5 phase III trial with a median follow-up of 58 months.

Results: CMV IgG and IgM positivity was seen in 51% and 6% of the patients, respectively. In multivariate analysis CMV IgG and CMV IgM serology show an age-depending effect for PFS. We identified positive CMV IgG/positive CMV IgM serology as an age-depending beneficial factor on PFS.

Discussion: Younger patients with a positive CMV IgG/positive CMV IgM serology experienced a favorable effect on PFS, whereas a positive CMV IgG/positive CMV IgM serology at older age has a disadvantageous effect on PFS.

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在 GMMG-MM5 III 期试验中接受治疗的新诊断多发性骨髓瘤患者的巨细胞病毒免疫球蛋白血清学流行率。

目的：巨细胞病毒（CMV）抗体血清阳性率是接受异体干细胞移植患者预后不良的既定因素。方法：在此，我们分析了GMMG-MM5 III期试验中446名新诊断的多发性骨髓瘤（MM）患者的CMV免疫球蛋白（Ig）血清学情况，中位随访时间为58个月：CMV IgG 和 IgM 阳性的患者分别占 51% 和 6%。在多变量分析中，CMV IgG 和 CMV IgM 血清学对 PFS 的影响与年龄有关。我们发现，CMV IgG阳性/CMV IgM血清学阳性是影响PFS的一个与年龄有关的有利因素：讨论：CMV IgG 阳性/CMV IgM 血清学阳性的年轻患者对 PFS 有有利影响，而年龄较大的 CMV IgG 阳性/CMV IgM 血清学阳性患者对 PFS 有不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hematology 医学-血液学

CiteScore

2.60

自引率

5.30%

发文量

140

审稿时长

3 months

期刊介绍： Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.