New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.

IF 1.2 Q2 MEDICINE, GENERAL & INTERNAL Medwave Pub Date : 2024-02-26 DOI:10.5867/medwave.2024.01.2754

Alejndro Levi-Monsalve, Sergio Vladimir Flores, Germán Manriquez, Ángel Roco-Videla

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Abstract

Background: Two new SNPs have been recently associated to Alzheimer's disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G. The risk of Alzheimer's disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association between these and other single nucleotide polymorphisms (SNPs) has not been assessed.

Methods: Linkage disequilibrium analysis, with r= 0.8 as a threshold value, was used to impute new candidate SNPs, on genomic data from both genes in 26 populations worldwide (n= 2504) from the 1000Genomes database.

Results: Four SNPs (rs13376485, rs3767640, rs3767639 and rs3767641) were linked to rs1050501 and one (rs2405442) to rs1859788 in the whole sample.

Conclusions: Five novel SNPs could be associated with Alzheimer's disease susceptibility and play a causal role, even if none of them are exon variants since their potential roles in the regulation of gene expression.

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与阿尔茨海默病遗传相关的新候选 SNPs：FCGRIIB 和 PILRA 基因的连锁不平衡分析。

背景：最近在非裔美国人中发现了两个与阿尔茨海默病相关的新 SNPs：FCGRIIB rs1050501 C/T 和 PILRA rs1859788 A/G：FCGRIIB rs1050501 C/T 和 PILRA rs1859788 A/G。FCGRIIB C 和 PILRA A 等位基因携带者患阿尔茨海默病的风险是非携带者的三倍。然而，这些单核苷酸多态性（SNPs）与其他单核苷酸多态性之间的关联尚未得到评估：方法：以 r= 0.8 为临界值，对来自 1000Genomes 数据库的全球 26 个人群（n= 2504）的两个基因的基因组数据进行了连锁不平衡分析，以推算新的候选 SNPs：在整个样本中，四个 SNP（rs13376485、rs3767640、rs3767639 和 rs3767641）与 rs1050501 相关，一个 SNP（rs2405442）与 rs1859788 相关：结论：5 个新的 SNPs 可能与阿尔茨海默病的易感性有关并起着因果作用，即使它们都不是外显子变异，因为它们在基因表达调控中可能发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medwave MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

12 weeks

期刊介绍： Medwave is a peer-reviewed, biomedical and public health journal. Since its foundation in 2001 (Volume 1) it has always been an online only, open access publication that does not charge subscription or reader fees. Since January 2011 (Volume 11, Number 1), all articles are peer-reviewed. Without losing sight of the importance of evidence-based approach and methodological soundness, the journal accepts for publication articles that focus on providing updates for clinical practice, review and analysis articles on topics such as ethics, public health and health policy; clinical, social and economic health determinants; clinical and health research findings from all of the major disciplines of medicine, medical science and public health. The journal does not publish basic science manuscripts or experiments conducted on animals. Until March 2013, Medwave was publishing 11-12 numbers a year. Each issue would be posted on the homepage on day 1 of each month, except for Chile’s summer holiday when the issue would cover two months. Starting from April 2013, Medwave adopted the continuous mode of publication, which means that the copyedited accepted articles are posted on the journal’s homepage as they are ready. They are then collated in the respective issue and included in the Past Issues section.