A real-life experience of long-term use of pilocarpine in irradiated head and neck cancer patients.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-02-26 DOI:10.1111/odi.14905

Rungarun Kittichet, Imjai Chitapanarux, Kittikun Kittidachanan, Patumrat Sripan

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引用次数: 0

Abstract

Aims: To assess long-term efficacy and side effects of pilocarpine on irradiated head and neck cancer (HNC) patients in both for prevention and treatment of radiation-induced xerostomia (RIX).

Methods: Retrospective observational study was conducted. Eligibility criteria included irradiated HNC patients who received pilocarpine at least 12 weeks either for prevention (group A) or for treatment (group B) of RIX. We collected the documented Late Effect Normal Tissue Task Force-Subjective, Objective, Management, Analytics subjective/objective grades of RIX before (only group B) and the latest visit for pilocarpine prescription, dosage, side effects, duration of treatment, and the cause of discontinuation.

Results: Between December 2007 and June 2022, 182 patients were enrolled including 95 patients (52%) in group A and 87 patients (48%) in group B. Group A patients reported grades 1, 2, 3, and 4 objective RIX in 0%, 7%, 93%, and 0%. Grade 1, 2, and 3 subjective RIX were 57%, 28%, and 15%. All patients in group B had grade 3 both objective/subjective RIX. The overall improvement of objective/subjective RIX was found in 40%/83%. Discontinuation was found in 51% of patients due to tolerable symptoms or deterioration of the patient's status.

Conclusions: Based on this retrospective analysis, long-term use of pilocarpine in irradiated HNC appears feasible for both prevention and treatment of RIX.

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头颈部癌症患者长期使用皮洛卡平的真实体验。

目的：评估皮洛卡平对接受放射治疗的头颈部癌症（HNC）患者预防和治疗放射引起的口腔干燥症（RIX）的长期疗效和副作用：方法：进行回顾性观察研究。研究对象包括接受皮洛卡平治疗至少 12 周以预防（A 组）或治疗（B 组）RIX 的 HNC 患者。我们收集了RIX前（仅B组）和最近一次就诊时的皮洛卡平处方、剂量、副作用、疗程和停药原因的晚期效应正常组织工作组-主观、客观、管理、分析主观/客观分级的记录：结果：2007 年 12 月至 2022 年 6 月期间，共有 182 名患者入组，其中 A 组 95 人（52%），B 组 87 人（48%）。1、2、3 级主观 RIX 分别为 57%、28% 和 15%。B 组所有患者的客观/主观 RIX 均为 3 级。40%/83%的患者的客观/主观RIX总体有所改善。51%的患者因症状可耐受或病情恶化而停药：根据这项回顾性分析，在辐照型 HNC 中长期使用皮洛卡平预防和治疗 RIX 似乎是可行的。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.