Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review

IF 2.7 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY OncoTargets and therapy Pub Date : 2024-02-27 DOI:10.2147/ott.s434286

Lan Liu, Meizuo Zhong, Xuan Zhou, Fanhua Kang, Yong Long, Junfeng Li

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Abstract

Abstract: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive malignancy. Most patients are diagnosed at a late stage with poor prognosis. The treatment usually includes combined intensive chemotherapy, cytoreductive surgery, radiotherapy, and targeted therapy. Due to the low incidence rate and dismal survival, there is currently a lack of case reports on DSRCT with concurrent leukemia. We report a case of a young patient who achieved disease stabilization for 14 months after receiving 6 cycles of chemotherapy and whole abdominal radiation therapy (WART), followed by consolidation treatment with anlotinib. However, the treatment was terminated due to the development of Acute Myeloid Leukemia-M5 (AML-M5). Multimodal therapy may provide a survival benefit for rare tumors that lack standard treatment. However, intensive chemotherapy and extensive radiotherapy carry a risk of inducing secondary malignancies. This is the first reported case of concurrent DSRCT and AML-M5 with short intervals between onset.

Keywords: desmoplastic small round cell tumor, whole abdominal radiation therapy, anlotinib, therapy-related acute myeloid leukemia

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治疗腹部去势小圆形细胞瘤诱发急性髓性白血病-M5：病例报告和文献综述

摘要：去瘤小圆细胞瘤（DSRCT）是一种罕见的侵袭性极强的恶性肿瘤。大多数患者确诊时已是晚期，预后较差。治疗通常包括联合强化化疗、细胞减灭术、放疗和靶向治疗。由于该病发病率低、生存率低，目前还缺乏关于 DSRCT 并发白血病的病例报告。我们报告了一例年轻患者，在接受了 6 个周期的化疗和全腹放疗（WART）后，又接受了安罗替尼的巩固治疗，病情稳定了 14 个月。然而，由于出现急性髓性白血病-M5（AML-M5），治疗终止。多模式疗法可为缺乏标准疗法的罕见肿瘤患者带来生存益处。然而，强化化疗和广泛放疗有诱发继发性恶性肿瘤的风险。这是首例并发DSRCT和AML-M5且发病间隔很短的病例。关键词：脱屑性小圆形细胞瘤；全腹放疗；安罗替尼；治疗相关性急性髓性白血病

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来源期刊

OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY

CiteScore

9.70

自引率

0.00%

发文量

221

审稿时长

1 months

期刊介绍： OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.