Análisis transversal de una cohorte de personas de más de 65 años que viven con VIH

IF 2.6 4区 医学 Q3 INFECTIOUS DISEASES Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-06-01 DOI:10.1016/j.eimc.2024.01.008
Iván Fernández-Castro, Clara Casar-Cocheteux, Hadrian Pernas-Pardavila, Elena Losada-Arias, Antonio Antela
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Abstract

Introduction

This study aims to describe and analyze the characteristics of aged people who are living with HIV (APHIV) and evaluate their association on the comorbidities they currently have.

Methods

Cross-sectional analysis of APHIV under active follow-up at the Infectious Diseases Unit of the University Clinical Hospital of Santiago de Compostela. Demographic and clinical data were analyzed, along with their association with the development of comorbidities in this population. A correlation and multiple linear regression analysis were performed for this purpose.

Results

Eighty-five APHIV, 65 males and 20 females, with an average age of 69 years (IQR: 8) and a duration of living with HIV of 17 years (SD: 7), were studied. 41% of them had their initial diagnosis with AIDS. The most common comorbidities are hypertension and dyslipidemia in 55% and 52%, respectively. 40% of APHIV take at least 5 medications. 35% have received more than 5 lines of antiretroviral treatment. At the time of analysis, all APHIV have an undetectable viral load. No significant association was observed between the number of comorbidities and various characteristics of APHIV; however, a weak correlation was noted among age, the cumulative number of antiretroviral treatments received throughout their lives, and the number of comorbidities.

Conclusions

This analysis highlights the substantial burden of comorbidities and polypharmacy experienced by APHIV. Further studies are needed to better understand the characteristics and variables influencing their development.

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对 65 岁以上艾滋病毒感染者队列的横断面分析
本研究旨在描述和分析 65 岁以上艾滋病病毒感染者(PLWHIV)的特征,并评估这些特征与他们当前合并症的关系。对圣地亚哥-德孔波斯特拉大学医院传染病科积极跟踪的艾滋病毒感染者进行横断面分析。分析了人口统计学和临床数据,以及这些数据与该人群中出现的合并症之间的关系,并进行了相关性和多元线性回归分析。85 名艾滋病毒感染者中,65 名男性,20 名女性,平均年龄为 69 岁(RIC:8),感染艾滋病毒的时间为 17 年(SD:7)。41%的患者最初患有艾滋病。最常见的并发症是高血压和血脂异常,分别占 55% 和 52%。40% 的 PLWHIV 至少服用 5 种药物。35%的 PLWHIV 接受过 5 种以上的抗逆转录病毒治疗。在进行分析时,所有 PLHIV 的病毒载量均检测不到。合并症的数量与 PLHIV 的不同特征之间没有关联;但年龄、一生中接受抗逆转录病毒治疗的次数和接受抗逆转录病毒治疗的次数之间存在微弱的相关性。这项分析凸显了 PLHIV 中合并症和多重药物治疗带来的沉重负担。需要进一步开展研究,以更好地确定影响其发展的特征和变量。
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来源期刊
CiteScore
2.10
自引率
8.00%
发文量
194
审稿时长
29 days
期刊介绍: Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.
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