The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats.

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE International Journal of Oral Science Pub Date : 2024-02-28 DOI:10.1038/s41368-024-00284-1
Wenhao Zheng, Xiaofeng Lu, Guangjin Chen, Yufeng Shen, Xiaofei Huang, Jinfeng Peng, Jiajia Wang, Ying Yin, Wencheng Song, Mengru Xie, Shaoling Yu, Lili Chen
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Abstract

The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment. However, the sensitivity of existing detection techniques is not sufficient, and the criteria for evaluating optimal force have not been yet established. Here, by employing 3D finite element analysis methodology, we found that the apical distal region (A-D region) of mesial roots is particularly sensitive to orthodontic force in rats. Tartrate-resistant acidic phosphatase (TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams (g), leading to alveolar bone resorption and tooth movement. When the force reached 80 g, TRAP-positive osteoclasts started appearing on the root surface in the A-D region. Additionally, micro-computed tomography revealed a significant root resorption at 80 g. Notably, the A-D region was identified as a major contributor to whole root resorption. It was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement, inclination, and hyalinization. These findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat model. Collectively, our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients' orthodontic treatment.

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磨牙中根根尖远端区域的破骨细胞活性会影响大鼠牙齿的正畸移动和牙根吸收。
在正畸治疗过程中,使用最佳正畸力对于防止不良副作用和确保牙齿有效移动至关重要。然而,现有检测技术的灵敏度不够,最佳力的评估标准也尚未确立。在此,通过采用三维有限元分析方法,我们发现大鼠中牙根的根尖远端区域(A-D 区域)对正畸力特别敏感。抗酒石酸磷酸酶(TRAP)阳性破骨细胞在 40 克(g)的力作用下开始在 A-D 区聚集,导致牙槽骨吸收和牙齿移动。当作用力达到 80 克时,A-D 区的牙根表面开始出现 TRAP 阳性破骨细胞。此外,显微计算机断层扫描显示 80 g 时牙根有明显的吸收。值得注意的是,A-D 区被确定为整个牙根吸收的主要区域。根据对牙齿移动、倾斜和透明化的分析,40 克是牙齿移动的最小有效力,且副作用最小。这些研究结果表明,在评估大鼠模型的正畸力时,A-D 区及其牙根表面的变化是一个重要的考虑因素和敏感指标。总之,我们对这一区域的研究将有助于在患者的正畸治疗过程中预防和减少牙根吸收。
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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
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