Progress in the development and use of monoclonal antibodies to study the evolution and function of the immune systems in the extant lineages of ungulates

IF 1.4 3区农林科学 Q4 IMMUNOLOGY Veterinary immunology and immunopathology Pub Date : 2024-02-23 DOI:10.1016/j.vetimm.2024.110730

William C. Davis, Asmaa H. Mahmoud, Victoria Hulubei, Amany Hasan, Gaber S. Abdellrazeq

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Abstract

Details on the origin and function of the immune system are beginning to emerge from genomic studies tracing the origin of B and T cells and the major histocompatibility complex. This is being accomplished through identification of DNA sequences of ancestral genes present in the genomes of lineages of vertebrates that have evolved from a common primordial ancestor. Information on the evolution of the composition and function of the immune system is being obtained through development of monoclonal antibodies (mAbs) specific for the MHC class I and II molecules and differentially expressed on leukocytes differentiation molecules (LDM). The mAbs have provided the tools needed to compare the similarities and differences in the phenotype and function of immune systems that have evolved during speciation. The majority of information currently available on evolution of the composition and function of the immune system is derived from study of the immune systems in humans and mice. As described in the present review, further information is beginning to emerge from comparative studies of the immune systems in the extant lineages of species present in the two orders of ungulates, Perissodactyla and Artiodactyla. Methods have been developed to facilitate comparative research across species on pathogens affecting animal and human health.

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在开发和使用单克隆抗体研究现存蹄类动物免疫系统的进化和功能方面取得的进展

追溯 B 细胞、T 细胞和主要组织相容性复合体起源的基因组研究开始揭示免疫系统起源和功能的细节。这项工作是通过鉴定从共同原始祖先进化而来的脊椎动物各系基因组中祖先基因的 DNA 序列来完成的。通过开发针对 MHC I 类和 II 类分子的特异性单克隆抗体（mAbs）以及在白细胞分化分子（LDM）上的差异表达，正在获得有关免疫系统组成和功能进化的信息。mAbs 为比较物种进化过程中免疫系统表型和功能的异同提供了必要的工具。目前有关免疫系统组成和功能进化的大部分信息都来自对人类和小鼠免疫系统的研究。正如本综述所述，对有蹄类动物的两个目（奇蹄目和有蹄目）现存物种的免疫系统进行的比较研究开始提供更多信息。目前已开发出一些方法，以促进对影响动物和人类健康的病原体进行跨物种比较研究。

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来源期刊

Veterinary immunology and immunopathology 农林科学-免疫学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

70 days

期刊介绍： The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease. Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above. The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.