Using Synthetic Biology to Understand the Function of Plant Specialized Metabolites.

IF 21.3 1区 生物学 Q1 PLANT SCIENCES Annual review of plant biology Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI:10.1146/annurev-arplant-060223-013842
Yuechen Bai, Xinyu Liu, Ian T Baldwin
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引用次数: 0

Abstract

Plant specialized metabolites (PSMs) are variably distributed across taxa, tissues, and ecological contexts; this variability has inspired many theories about PSM function, which, to date, remain poorly tested because predictions have outpaced the available data. Advances in mass spectrometry-based metabolomics have enabled unbiased PSM profiling, and molecular biology techniques have produced PSM-free plants; the combination of these methods has accelerated our understanding of the complex ecological roles that PSMs play in plants. Synthetic biology techniques and workflows are producing high-value, structurally complex PSMs in quantities and purities sufficient for both medicinal and functional studies. These workflows enable the reengineering of PSM transport, externalization, structural diversity, and production in novel taxa, facilitating rigorous tests of long-standing theoretical predictions about why plants produce so many different PSMs in particular tissues and ecological contexts. Plants use their chemical prowess to solve ecological challenges, and synthetic biology workflows are accelerating our understanding of these evolved functions.

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利用合成生物学了解植物特化代谢物的功能。
植物专化代谢物(PSMs)在不同类群、组织和生态环境中的分布各不相同;这种差异性激发了许多有关 PSM 功能的理论,但由于预测超过了可用数据,这些理论至今仍未得到充分验证。基于质谱的代谢组学的进步实现了无偏见的 PSM 分析,而分子生物学技术则培育出了无 PSM 植物;这些方法的结合加速了我们对 PSM 在植物中发挥的复杂生态作用的理解。合成生物学技术和工作流程正在生产高价值、结构复杂的 PSM,其数量和纯度足以满足药用和功能研究的需要。这些工作流程能够重新设计 PSM 的运输、外化、结构多样性以及新型类群的生产,从而有助于严格检验长期以来的理论预测,即植物为什么会在特定组织和生态环境中产生如此多不同的 PSM。植物利用其化学能力解决生态挑战,而合成生物学工作流程正在加速我们对这些进化功能的理解。植物生物学年刊》第 75 卷的最终在线出版日期预计为 2024 年 5 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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来源期刊
Annual review of plant biology
Annual review of plant biology 生物-植物科学
CiteScore
40.40
自引率
0.40%
发文量
29
期刊介绍: The Annual Review of Plant Biology is a peer-reviewed scientific journal published by Annual Reviews. It has been in publication since 1950 and covers significant developments in the field of plant biology, including biochemistry and biosynthesis, genetics, genomics and molecular biology, cell differentiation, tissue, organ and whole plant events, acclimation and adaptation, and methods and model organisms. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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