Reduction of N-acetyl aspartate (NAA) in association with relapse in early-stage psychosis: a 7-Tesla MRS study.

IF 3 Q2 PSYCHIATRY Schizophrenia (Heidelberg, Germany) Pub Date : 2024-03-01 DOI:10.1038/s41537-024-00451-7
Marina Mihaljevic, Yu-Ho Chang, Ashley M Witmer, Jennifer M Coughlin, David J Schretlen, Peter B Barker, Kun Yang, Akira Sawa
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Abstract

Understanding the biological underpinning of relapse could improve the outcomes of patients with psychosis. Relapse is elicited by multiple reasons/triggers, but the consequence frequently accompanies deteriorations of brain function, leading to poor prognosis. Structural brain imaging studies have recently been pioneered to address this question, but a lack of molecular investigations is a knowledge gap. Following a criterion used for recent publications by others, we defined the experiences of relapse by hospitalization(s) due to psychotic exacerbation. We hypothesized that relapse-associated molecules might be underscored from the neurometabolites whose levels have been different between overall patients with early-stage psychosis and healthy subjects in our previous report. In the present study, we observed a significant decrease in the levels of N-acetyl aspartate in the anterior cingulate cortex and thalamus in patients who experienced relapse compared to patients who did not. Altogether, decreased N-acetyl aspartate levels may indicate relapse-associated deterioration of neuronal networks in patients.

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N-乙酰天冬氨酸(NAA)的减少与早期精神病复发有关:一项 7-Tesla MRS 研究。
了解复发的生物学基础可以改善精神病患者的预后。复发是由多种原因/诱因引起的,但其后果往往伴随着大脑功能的恶化,导致预后不良。最近,大脑结构成像研究已成为解决这一问题的先驱,但分子研究的缺乏却是一个知识空白。根据其他人最近发表的文章所采用的标准,我们将精神病恶化导致的住院经历定义为复发。我们假设,与复发相关的分子可能来自神经代谢物,在我们之前的报告中,早期精神病患者与健康人之间的神经代谢物水平存在差异。在本研究中,我们观察到,与未复发的患者相比,复发患者前扣带回皮层和丘脑中的 N-乙酰天冬氨酸水平明显下降。总之,N-乙酰天冬氨酸水平的降低可能表明患者的神经元网络因复发而恶化。
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