GLP-1 receptor agonists: A novel pharmacotherapy for binge eating (Binge eating disorder and bulimia nervosa)? A systematic review

IF 3.3 Q1 ENDOCRINOLOGY & METABOLISM Journal of Clinical and Translational Endocrinology Pub Date : 2024-03-01 Epub Date: 2024-02-29 DOI:10.1016/j.jcte.2024.100333

Laurence Aoun , Shaza Almardini , Fares Saliba , Fadi Haddadin , Omar Mourad , Jennifer Jdaidani , Zeina Morcos , Ibrahim Al Saidi , Elie Bou Sanayeh , Saliba Saliba , Michel Almardini , Julie Zaidan

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Abstract

Objective

Systematically review evidence on using GLP-1RAs for reducing BEB in BED and BN.

Methods

Comprehensive literature search (PubMed and Google Scholar) conducted for studies evaluating GLP-1Ras for BEB. Extracted data on study characteristics, efficacy, and safety.

Results

Studies show that GLP-1RAs (liraglutide and dulaglutide) reduce BE frequency and comorbidities in addition to favorable psychiatric side effect profile compared to current options. However, large-scale, blinded placebo-controlled trials are lacking.

Conclusion

Early findings suggest promising effects of GLP-1RAs on BEB. However, rigorous clinical trials are needed to firmly establish efficacy, dosing, safety, and comparative effectiveness before considering GLP-1RAs a viable novel approach.

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GLP-1 受体激动剂：治疗暴食症（暴食症和贪食症）的新型药物疗法？系统综述

目的系统回顾使用 GLP-1RAs 减少 BED 和 BN 中 BEB 的证据。方法对评估 GLP-1Ras 治疗 BEB 的研究进行全面文献检索（PubMed 和 Google Scholar）。结果研究表明，GLP-1RAs（利拉鲁肽和度拉鲁肽）与目前的选择相比，除了具有良好的精神副作用外，还能减少 BEB 的频率和合并症。结论早期研究结果表明，GLP-1RA 对 BEB 具有良好的疗效。然而，在将 GLP-1RAs 视为一种可行的新方法之前，还需要进行严格的临床试验，以牢固确立其疗效、剂量、安全性和比较有效性。

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