Journal of Clinical and Translational Endocrinology最新文献

{"title":"68Ga-pentixafor PET/CT in guiding surgical management of primary aldosteronism","authors":"Guoyang Zheng ,&nbsp;Jie Ding ,&nbsp;Yinjie Gao ,&nbsp;Shengyan Liu ,&nbsp;Xinchun Yan ,&nbsp;Wenda Wang ,&nbsp;Yang Zhao ,&nbsp;Zhan Wang ,&nbsp;Li Huo ,&nbsp;Anli Tong ,&nbsp;Yushi Zhang","doi":"10.1016/j.jcte.2025.100384","DOIUrl":"10.1016/j.jcte.2025.100384","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to explore the significance of ⁶⁸Ga-pentixafor PET/CT in guiding surgical treatments for primary aldosteronism (PA) patients, by identifying functional lesions and determining the dominant side of aldosterone secretion.</div></div><div><h3>Materials and methods</h3><div>We prospectively included 91 PA patients receiving surgical treatments based on the results of ⁶⁸Ga-pentixafor PET/CT. The ⁶⁸Ga-pentixafor PET/CT images were evaluated by visual and semi-quantitative analysis. The relationship between radionuclide imaging characteristics and postoperative outcomes was assessed following surgery.</div></div><div><h3>Results</h3><div>The positive detection rate of ⁶⁸Ga-pentixafor PET/CT in 91 PA patients was 85.7 % (78/91) with a median maximum standardized uptake value (SUV_max) of 10.2 (6.0–16.0). The SUV_max was positively correlated with lesion diameter (<em>r</em> = 0.497, <em>P</em> &lt; 0.001), while negatively correlated with the blood potassium level (<em>r</em> = -0.450, <em>P</em> &lt; 0.001) and plasma renin activity (<em>r</em> = -0.297, <em>P</em> = 0.004). 63 cases of 73 PA patients with unilateral adrenal lesion were identified positive by ⁶⁸Ga-pentixafor PET/CT, and 95.2 % of the 63 positive cases benefited from surgical resection of the identified positive lesions. Among 18 PA patients with bilateral lesions, ⁶⁸Ga-pentixafor PET/CT identified positive lesions in 15 cases, and 86.7 % (13/15) of the positive cases benefited from total or partial adrenalectomy guided by ⁶⁸Ga-pentixafor PET/CT. There was no significant difference in postoperative outcomes between patients undergoing partial adrenalectomy with those subjected to total adrenalectomy. The accuracy rate of ⁶⁸Ga-pentixafor PET/CT in determining the dominant side of aldosterone secretion for PA was 85.7 %, which was comparable to the 71.4 % of adrenal vein sampling (AVS).</div></div><div><h3>Conclusions</h3><div>⁶⁸Ga-pentixafor PET/CT could effectively guide the surgical management for PA patients, achieving favorable postoperative outcomes. The accuracy rate of ⁶⁸Ga-pentixafor PET/CT in identifying the dominant side of aldosterone secretion was not inferior to that of AVS.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"39 ","pages":"Article 100384"},"PeriodicalIF":4.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular function in postpubertal patients with growth hormone deficiency: A prospective controlled study","authors":"Rossella Cannarella ,&nbsp;Andrea Crafa ,&nbsp;Sabrina Sapienza ,&nbsp;Roberto Curto ,&nbsp;Manuela M. Caruso ,&nbsp;Rosita A. Condorelli ,&nbsp;Sandro La Vignera ,&nbsp;Aldo E. Calogero","doi":"10.1016/j.jcte.2025.100383","DOIUrl":"10.1016/j.jcte.2025.100383","url":null,"abstract":"<div><h3>Background</h3><div>We have previously shown that treatment with recombinant human growth hormone (GH) influences testicular growth in children with GH deficiency (GHD) and have suggested that GH plays a role in testicular growth in childhood. Little evidence is available on testicular function in post-pubertal GHD patients.</div></div><div><h3>Objective</h3><div>This prospective controlled study was undertaken to evaluate testicular function in patients with GHD.</div></div><div><h3>Patients and Methods</h3><div>Post-pubertal patients with non-syndromic GHD over the age of 16 years were enrolled. Each patient underwent to the assessment of serum levels of gonadotropins and total testosterone (TT), conventional sperm parameters, and testicular volume (TV) measured by ultrasound examination. Age-matched healthy subjects served as controls. Patients with disorders capable of interfering with testicular function were excluded.</div></div><div><h3>Results</h3><div>26 patients with GHD and 25 age-matched post-pubertal controls were enrolled. They did not differ in serum luteinizing hormone, follicle-stimulating hormone, and TT levels. However, GHD patients had lower semen volume, total sperm count, progressive motility, and total motility values, and a higher prevalence of oligozoospermia compared to controls. No difference was found in sperm concentration and normal morphology. Importantly, GHD patients had lower TV, and a higher prevalence of testicular hypotrophy.</div></div><div><h3>Conclusion</h3><div>This is the first evidence of mildly impaired sperm parameters and TV in GHD patients compared to healthy controls. The integrity of the GH-IGF1 axis in prepuberty is important for achieving normal testicular function in adulthood. Evaluating testicular growth over time in GHD children and measuring TV and sperm parameters in postpubertal GHD boys is advisable.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"39 ","pages":"Article 100383"},"PeriodicalIF":4.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can ACR TI-RADS predict the malignant risk of medullary thyroid cancer?","authors":"Ying Zhang ,&nbsp;Bei-Bei Ye ,&nbsp;Han-Xiang Wang ,&nbsp;Bo-Ji Liu ,&nbsp;Yun-Yun Liu ,&nbsp;Qing Wei ,&nbsp;Chuan Qin ,&nbsp;Yi-Feng Zhang","doi":"10.1016/j.jcte.2024.100380","DOIUrl":"10.1016/j.jcte.2024.100380","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the diagnostic performance for medullary thyroid cancer (MTC) based on the 2017 Thyroid Imaging Reporting and Data System by the American College of Radiology (ACR TI-RADS) guideline, and the ability to recommend fine needle aspiration (FNA) for MTC.</div></div><div><h3>Methods</h3><div>Fifty-six MTCs were included, and 168 benign thyroid nodules (BTNs) and 168 papillary thyroid nodules (PTCs) were matched according to age. Ultrasound (US) features were reviewed according to ACR TI-RADS. US, clinical features and diagnostic performance of cytology of MTC, BTN and PTC were compared. Multivariate logistic regression analysis was performed to assess independent variables to predict MTC.</div></div><div><h3>Results</h3><div>Multivariate logistic regression showed that position, hypoechoic, AP/T ratio ≥ 0.9 and marked internal blood flow were independent predictors of MTC compared to BTN (P &lt; 0.05) and nodule sizes, AP/T ratio &lt; 1, smooth or ill-defined margin and marked internal blood flow were independent predictors of MTC compared to PTC (P &lt; 0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of MTC based on ACR TI-RADS was inferior to that of PTC (0.687 vs 0.823) (P &lt; 0.001). The recommended rate of FNA for MTC and PTC was 55.4 and 88.7 % respectively. 8 of 14 MTCs with negative FNA results (Bethesda II) had abnormal calcitonin (Ctn) results.</div></div><div><h3>Conclusions</h3><div>Based on the ACR TI-RADS classification, the malignant risk features of MTC were intermediate between BTN and PTC. The diagnostic efficacy of MTC and FNA recommendation rate were inferior to PTC. Ctn examination would reduce the FNA missed diagnosis of MTC.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"39 ","pages":"Article 100380"},"PeriodicalIF":4.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of Neutrophil-to-Lymphocyte ratio with metabolic syndrome in U.S. Adults: Findings from the 1999–2018 National Health and Nutrition Examination survey","authors":"Zahra Sarrafan-Chaharsoughi ,&nbsp;Ninet Sinaii ,&nbsp;Andrew P Demidowich ,&nbsp;Jack A Yanovski","doi":"10.1016/j.jcte.2024.100382","DOIUrl":"10.1016/j.jcte.2024.100382","url":null,"abstract":"<div><h3>Background</h3><div>Identifying and treating metabolic syndrome (MetS) early is of great importance, as MetS portends numerous negative health outcomes. Identifying an inexpensive, readily available inflammatory biomarker that accurately predicts MetS could be of use to clinicians.</div></div><div><h3>Methods</h3><div>The aim of this study was to evaluate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and MetS in U.S. adults. We used data from adult participants of the 1999–2018 National Health and Nutrition Examination Surveys to conduct a cross-sectional study. MetS was determined using National Cholesterol Education Program Adult Treatment Panel III (2005 revision) criteria; NLR was calculated by dividing the absolute neutrophil count by absolute lymphocyte count. Data were weighted and analyzed using survey procedures in SAS v9.4.</div></div><div><h3>Results</h3><div>Data from 101,316 participants were reviewed, of whom 19,613 were eligible for weighted analysis. MetS was observed in 40.3 % of participants (n = 7,896), who met 3 <em>(n</em> = 3,902; 49.4 %), 4 (n = 2,817; 35.7 %), and 5 (n = 1,177; 14.9 %) criteria of MetS, respectively. Across the survey years, NLR was higher in those with MetS compared to those without (mean 2.24 [95 % CI 2.21, 2.28] vs 2.05 [95 % CI 2.02, 2.08]; <em>p</em> &lt; 0.001). There was a consistent trend of increasing NLR according to MetS severity (<em>p</em> &lt; 0.001). An NLR cutoff of 1.67 had 74.3 % sensitivity and 62.3 % specificity for MetS with Area-under-the-curve of 0.736 [95 % CI 0.73, 0.74].</div></div><div><h3>Conclusions</h3><div>Among U.S. adults, NLR was associated with MetS and MetS severity, independent of age and race/ethnicity.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"39 ","pages":"Article 100382"},"PeriodicalIF":4.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of gender-affirming hormone therapy on myocardial, hepatic, pancreatic lipid content, body fat distribution and other cardiometabolic risk factors: A magnetic resonance-based study in transgender individuals","authors":"Dorota Sluková ,&nbsp;Carola Deischinger ,&nbsp;Ivica Just ,&nbsp;Ulrike Kaufmann ,&nbsp;Siegfried Trattnig ,&nbsp;Martin Krššák ,&nbsp;Lana Kosi-Trebotic ,&nbsp;Juergen Harreiter ,&nbsp;Alexandra Kautzky-Willer","doi":"10.1016/j.jcte.2024.100379","DOIUrl":"10.1016/j.jcte.2024.100379","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to assess the changes in body fat distribution, intraorgan lipid accumulation, and cardiometabolic risk factors after 6 months of gender-affirming hormone therapy (GAHT) in transgender men (TM) and transgender women (TW).</div></div><div><h3>Methods</h3><div>Conducted at the Medical University of Vienna between 2019 and 2022, the study included 15 TW and 20 TM. We conducted magnetic resonance imaging and spectroscopy to determine the visceral (VAT) and subcutaneous adipose tissue (SAT) amounts, the VAT/SAT ratio, and the intraorgan lipid content (liver, pancreas, myocardium), bloodwork, and an oral glucose tolerance test at baseline and after 6 months of GAHT.</div></div><div><h3>Results</h3><div>Pancreatic, hepatic, and intramyocardial lipid contents did not significantly change in either group after 6 months of GAHT. In TW, VAT/SAT ratio decreased significantly from baseline 0,930 (IQR 0,649–1,287) to 0,758 (IQR 0,424–0,900; p = 0,011) after 6 months of GAHT. The updated homeostatic model assessment for insulin sensitivity (HOMA2-%S) significantly decreased from 83,03 % (±31,11) to 64,27 % (±18,01; p = 0,047), indicating decreased insulin sensitivity, while the updated homeostatic model assessment for β-cell function (HOMA2-%β) increased (from 128,11 % (±35,80) to 156,80 % (±39,49); p = 0,020) in TW after 6 months of GAHT. In TM, there were no changes in glucose metabolism parameters except for an increase in HbA_1c (5,1% (±0,3) vs 5,3% (±0,4), p = 0,001).</div></div><div><h3>Conclusions</h3><div>6 months of GAHT were not associated with statistically significant changes in myocardial, hepatic, or pancreatic lipid content. Short-term GAHT led to a marked body fat redistribution with a significant decrease in the VAT/SAT ratio in TW.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"39 ","pages":"Article 100379"},"PeriodicalIF":4.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple prediction model for vitamin D deficiency in women with osteoporosis or risk factors for osteoporosis in Thailand","authors":"Tidaporn Mullikapipat ,&nbsp;Natee Dumrongwongsuwinai ,&nbsp;Orawin Vallibhakara ,&nbsp;Sasivimol Rattanasiri ,&nbsp;Sakda Arj-Ong Vallibhakara ,&nbsp;Wiwat Wajanavisit ,&nbsp;Boonsong Ongphiphadhanakul ,&nbsp;Hataikarn Nimitphong","doi":"10.1016/j.jcte.2024.100377","DOIUrl":"10.1016/j.jcte.2024.100377","url":null,"abstract":"<div><h3>Introduction</h3><div>In Thailand, the assessment of vitamin D status by measuring 25-hydroxyvitamin D[25(OH)D] levels in individuals at risk for osteoporosis is constrained by limited facilities and high costs. This study aimed to create a clinical model for predicting vitamin D deficiency in women with osteoporosis or risk factors for osteoporosis.</div></div><div><h3>Materials and Methods</h3><div>This was a cross-sectional study of 490 women. All participants had 25(OH)D levels measured. A questionnaire was used to assess factors related to vitamin D status. Vitamin D deficiency was defined as 25(OH)D levels &lt; 30 ng/mL. Logistic regression analyses were conducted to investigate predictors of vitamin D deficiency. In the model, odds ratios (ORs) were converted into simple scores. The optimal cutoff for women at a high risk of vitamin D deficiency was established. Internal validation was assessed using a Bootstrap.</div></div><div><h3>Results</h3><div>Sixty percent had vitamin D deficiency. The final model for predicting vitamin D deficiency consisted of a body mass index ≥ 25 kg/m² (OR:1.15), lack of exercise (OR:1.59), exercise 1–2 times/week (OR:1.40), sunlight exposure &lt; 15 min/day (OR:1.70), no vitamin D supplementation (OR:8.76), and vitamin D supplementation of 1–20,000 IU/week (OR:2.31). The area under the curve was 0.747. At a cutoff of 6.6 in total risk score (range 4–13.6), the model predicted vitamin D deficiency with a sensitivity of 71.9 % and a specificity of 65.3 %. The internal validation by Bootstrap revealed a ROC of 0.737.</div></div><div><h3>Conclusions</h3><div>In women at risk of osteoporosis, a simple risk score can identify individuals with a high risk of vitamin D deficiency. These women could benefit from vitamin D supplementation without requiring 25(OH)D measurements.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"38 ","pages":"Article 100377"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Safety and efficacy of semaglutide in post kidney transplants patients with type 2 diabetes or post-transplant diabetes” [J. Clin. Translat. Endoc. 36C (2024) 100343]","authors":"Moeber Mohammed Mahzari ,&nbsp;Omar Buraykan Alluhayyan ,&nbsp;Mahdi Hamad Almutairi ,&nbsp;Mohammed Abdullah Bayounis ,&nbsp;Yazeed Hasan Alrayani ,&nbsp;Amir A. Omair ,&nbsp;Awad Saad Alshahrani","doi":"10.1016/j.jcte.2024.100360","DOIUrl":"10.1016/j.jcte.2024.100360","url":null,"abstract":"","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"38 ","pages":"Article 100360"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141712363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK7 levels in women with and without PCOS","authors":"Stephen L. Atkin ,&nbsp;Alexandra E Butler ,&nbsp;Tannaz Jamialahmadi ,&nbsp;Amirhossein Sahebkar","doi":"10.1016/j.jcte.2024.100376","DOIUrl":"10.1016/j.jcte.2024.100376","url":null,"abstract":"","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"38 ","pages":"Article 100376"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The right drug for the right patient at the right time with the right test in differentiated thyroid cancer (DTC)","authors":"Dario de Biase ,&nbsp;Andrea Repaci ,&nbsp;Maria Concetta Nigro ,&nbsp;Thais Maloberti ,&nbsp;Francesca Carosi ,&nbsp;Maria A. Pantaleo ,&nbsp;Giovanni Tallini ,&nbsp;Margherita Nannini","doi":"10.1016/j.jcte.2024.100373","DOIUrl":"10.1016/j.jcte.2024.100373","url":null,"abstract":"<div><div>Thanks to the identification of crucial molecular pathways, the therapeutic landscape for advanced differentiated thyroid tumors (DTCs) has significantly improved during the last ten years. The therapeutic scenario has been greatly impacted by the discovery of mutually exclusive gene changes in the MAPK and PI3K/AKT pathways, such as <em>RET</em> or <em>NTRK</em> fusions and pathogenic mutations of the <em>BRAF</em> and <em>RAS</em> genes. Indeed, multi-kinase inhibitors and selective inhibitors have demonstrated outstanding efficacy for radioactive iodine-refractory (RAI-R) drug treatment, with overall response rates reaching up to 86%. Thus, for RAI-R DTCs, routine molecular testing for actionable gene alterations is now essential, for choosing the right therapy for the right patient.</div><div>Additionally, tumor genotyping also allows to identify a subset of patients with worse prognosis disease, which may deserve a tailored clinical management. Thus, the right test should also include non-driver <em>TERT</em>, <em>TP53</em>, <em>PIK3CA</em>, and other mutations of aggressiveness, with the aim of a molecular-based risk stratification. Therefore, tumor genotyping should be considered in the diagnostic work-up of metastatic DTC patients or with highly aggressive histological features, in order to give the right drug for the right patient at the right time.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"38 ","pages":"Article 100373"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143161734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating habits and carotenoid skin content among children based on their attendance at the school meals: A cross-sectional pilot study","authors":"Giovanna Caparello ,&nbsp;Fabrizio Ceraudo ,&nbsp;Francesca Meringolo ,&nbsp;Giuseppina Augimeri ,&nbsp;Giuseppe Morino ,&nbsp;Daniela Bonofiglio","doi":"10.1016/j.jcte.2024.100378","DOIUrl":"10.1016/j.jcte.2024.100378","url":null,"abstract":"<div><h3>Objective</h3><div>The promotion of a healthy diet, such as the Mediterranean Diet (MD), among childhood is of a particular importance, since eating behaviors learned early in life have been shown to be maintained into adolescence and adulthood. The most efficient intervention in childhood is the active involvement of the schools.</div></div><div><h3>Design</h3><div>The aim of this study was to evaluate the adherence to the MD model and the skin carotenoid levels among children divided by their school lunch attendance.</div></div><div><h3>Methods</h3><div>This cross-sectional study involved 132 pupils (64 girls and 68 boys), divided between children who ate lunch at school (44%) and at home (56%). The children who had meals provided by the school participated in activities promoting the health benefits of fruits and vegetables. All participants underwent anthropometric measurements and assessment of the MD adherence and the physical activity using KIDMED and PAQ-C questionnaires, respectively, and skin carotenoid content using the Veggie Meter®.</div></div><div><h3>Results</h3><div>We found mean KIDMED and PAQ-C scores, while skin carotenoid content was below the normal range in our population sample. Interestingly, children who ate lunch provided by the school had significantly higher carotenoid scores with respect to those who had lunch at home (<em>p = 0.005</em>). In multiple regression analyses, we found that carotenoid scores were positively influenced by gender (<em>p = 0.03</em>), school lunch attendance (<em>p = 0.01</em>) and daily vegetable consumption (<em>p = 0.0002</em>) in our children population sample.</div></div><div><h3>Conclusions</h3><div>Our results suggest the importance of promoting a healthy lifestyle at the school to improve eating habits during childhood as a strategy for disease prevention across the lifespan.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"38 ","pages":"Article 100378"},"PeriodicalIF":4.2,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}