{"title":"Extensive cutaneous-mucosal and muscular involvement of Gamma/Delta cutaneous T-cell lymphoma on [18F]FDG PET-CT","authors":"H. Peslier , K. Cohen Tannugi , J. Reichart","doi":"10.1016/j.mednuc.2024.01.068","DOIUrl":null,"url":null,"abstract":"<div><p>Gamma/delta T-cell lymphoma is a rare and aggressive subtype of primary cutaneous lymphoma. Clinical manifestations typically include the development of subcutaneous nodules and ulcerated plaques. Some forms present as panniculitis with hemophagocytic syndrome. Prognosis is bleak, with a 10% 5-year survival rate. In this report, we present the case of a 20-year old man from French Polynesia, referred for [<sup>18</sup>F]FDG PET-CT due to the progressive worsening of febrile cutaneous-mucosal infiltration on the face persisting for 1 month. PET examination guided a biopsy from the right deltoid muscle, and expert histological analysis confirmed a CD8+ NOS T-cell lymphoma, granzyme+ and TCR gamma/delta.</p></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"48 2","pages":"Page 78"},"PeriodicalIF":0.2000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0928125824000688","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Gamma/delta T-cell lymphoma is a rare and aggressive subtype of primary cutaneous lymphoma. Clinical manifestations typically include the development of subcutaneous nodules and ulcerated plaques. Some forms present as panniculitis with hemophagocytic syndrome. Prognosis is bleak, with a 10% 5-year survival rate. In this report, we present the case of a 20-year old man from French Polynesia, referred for [18F]FDG PET-CT due to the progressive worsening of febrile cutaneous-mucosal infiltration on the face persisting for 1 month. PET examination guided a biopsy from the right deltoid muscle, and expert histological analysis confirmed a CD8+ NOS T-cell lymphoma, granzyme+ and TCR gamma/delta.
γ/δT细胞淋巴瘤是原发性皮肤淋巴瘤中一种罕见的侵袭性亚型。临床表现通常包括皮下结节和溃疡性斑块。有些表现为伴有嗜血细胞综合征的泛发性皮炎。预后很差，5 年存活率仅为 10%。在本报告中，我们介绍了一名来自法属波利尼西亚的 20 岁男子的病例，他因面部发热性皮肤-粘膜浸润持续恶化 1 个月而转诊至[18F]FDG PET-CT。在 PET 检查的指导下，对右侧三角肌进行了活检，专家组织学分析证实这是一种 CD8+ NOS T 细胞淋巴瘤，颗粒酶+，TCR γ/δ。
期刊介绍：
Le but de Médecine nucléaire - Imagerie fonctionnelle et métabolique est de fournir une plate-forme d''échange d''informations cliniques et scientifiques pour la communauté francophone de médecine nucléaire, et de constituer une expérience pédagogique de la rédaction médicale en conformité avec les normes internationales.
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