DNA methylation variation after a parenting program for child conduct problems: Findings from a randomized controlled trial

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-03-04 DOI:10.1111/cdev.14090

Nicole Creasey, Patty Leijten, Marieke S. Tollenaar, Marco P. Boks, Geertjan Overbeek

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Abstract

This study investigated associations of the Incredible Years (IY) parenting program with children's DNA methylation. Participants were 289 Dutch children aged 3–9 years (75% European ancestry, 48% female) with above-average conduct problems. Saliva was collected 2.5 years after families were randomized to IY or care as usual (CAU). Using an intention-to-treat approach, confirmatory multiple-regression analyses revealed no significant differences between the IY and CAU groups in children's methylation levels at the NR3C1 and FKBP5 genes. However, exploratory epigenome-wide analyses revealed nine differentially methylated regions between groups, coinciding with SLAMF1, MITF, FAM200B, PSD3, SNX31, and CELSR1. The study provides preliminary evidence for associations of IY with children's salivary methylation levels and highlights the need for further research into biological outcomes of parenting programs.

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针对儿童行为问题的养育计划后的 DNA 甲基化变异：随机对照试验的结果。

本研究调查了 "不可思议的岁月"（IY）育儿计划与儿童 DNA 甲基化之间的关系。参与者为 289 名 3-9 岁的荷兰儿童（75% 为欧洲血统，48% 为女性），他们的行为问题高于平均水平。在家庭被随机分配到 IY 或照常护理 (CAU) 2.5 年后收集唾液。采用意向治疗方法进行的确认性多元回归分析表明，在 NR3C1 和 FKBP5 基因的甲基化水平上，益智组和照常护理组之间没有显著差异。然而，探索性的全表观基因组分析显示，组间存在九个不同的甲基化区域，分别是 SLAMF1、MITF、FAM200B、PSD3、SNX31 和 CELSR1。该研究提供了国际养育年与儿童唾液甲基化水平相关的初步证据，并强调了进一步研究养育计划生物学结果的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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