Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity.

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-03-04 DOI:10.1080/19490976.2024.2323234
Ye Peng, Hein M Tun, Siew C Ng, Hogan Kok-Fung Wai, Xi Zhang, Jaclyn Parks, Catherine J Field, Piush Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, Jeffrey R Brook, Tim K Takaro, James A Scott, Francis Kl Chan, Anita L Kozyrskyj
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Abstract

Childhood obesity is linked to maternal smoking during pregnancy. Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role is understudied. We included 1,592 infants from the Canadian Healthy Infants Longitudinal Development Cohort. Data on environmental exposure and lifestyle factors were collected prenatally and throughout the first three years. Weight outcomes were measured at one and three years of age. Stool samples collected at 3 and 12 months were analyzed by sequencing the V4 region of 16S rRNA to profile microbial compositions and magnetic resonance spectroscopy to quantify the metabolites. We showed that quitting smoking during pregnancy did not lower the risk of offspring being overweight. However, exclusive breastfeeding until the third month of age may alleviate these risks. We also reported that maternal smoking during pregnancy significantly increased Firmicutes abundance and diversity. We further revealed that Firmicutes diversity mediates the elevated risk of childhood overweight and obesity linked to maternal prenatal smoking. This effect possibly occurs through excessive microbial butyrate production. These findings add to the evidence that women should quit smoking before their pregnancies to prevent microbiome-mediated childhood overweight and obesity risk, and indicate the potential obesogenic role of excessive butyrate production in early life.

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母亲在怀孕期间吸烟会增加与肠道微生物相关的儿童超重和肥胖的风险。
儿童肥胖与母亲在怀孕期间吸烟有关。肠道微生物群可能部分介导了这种关联,并可能成为潜在的干预目标;然而,对其作用的研究还不充分。我们纳入了加拿大健康婴儿纵向发展队列中的 1,592 名婴儿。我们收集了产前和头三年的环境暴露和生活方式因素数据。体重结果在婴儿一岁和三岁时进行测量。对 3 个月和 12 个月时采集的粪便样本进行了分析,通过 16S rRNA 的 V4 区域测序来分析微生物组成,并通过磁共振光谱来量化代谢物。我们的研究表明,孕期戒烟并不会降低后代超重的风险。然而,纯母乳喂养到婴儿出生后第三个月可能会降低这些风险。我们还发现,母亲在怀孕期间吸烟会显著增加固着菌的丰度和多样性。我们还进一步发现,固形菌的多样性介导了与母亲产前吸烟有关的儿童超重和肥胖风险的升高。这种影响可能是通过微生物产生过多的丁酸盐产生的。这些发现增加了妇女应在怀孕前戒烟以防止微生物介导的儿童超重和肥胖风险的证据,并表明在生命早期过量丁酸盐的产生具有潜在的致肥胖作用。
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来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
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