Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-04 DOI:10.1177/0271678X241237072

Slim Fellah, Chunwei Ying, Yan Wang, Kristin P Guilliams, Melanie E Fields, Yasheng Chen, Josiah Lewis, Amy Mirro, Rachel Cohen, Nkemdilim Igwe, Cihat Eldeniz, Dengrong Jiang, Hanzhang Lu, William J Powers, Jin-Moo Lee, Andria L Ford, Hongyu An

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Abstract

Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the tissue level across the brain using an asymmetric spin echo (ASE) MR method, while variable global OEFs were found from the superior sagittal sinus (SSS) using a T2-relaxation-under-spin-tagging (TRUST) MRI method with different calibration models. In this study, we aimed to compare the average ASE-OEF in the SSS drainage territory and TRUST-OEF in the SSS from the same SCD patients and healthy controls. 74 participants (SCD: N = 49; controls: N = 25) underwent brain MRI. TRUST-OEF was quantified using the Lu-bovine, Bush-HbA and Li-Bush-HbS models. ASE-OEF and TRUST-OEF were significantly associated in healthy controls after controlling for hematocrit using the Lu-bovine or the Bush-HbA model. However, no association was found between ASE-OEF and TRUST-OEF in patients with SCD using either the Bush-HbA or the Li-Bush-HbS model. Plausible explanations include a discordance between spatially volume-averaged oxygenation brain tissue and flow-weighted volume-averaged oxygenation in SSS or sub-optimal calibration in SCD. Further work is needed to refine and validate non-invasive MR OEF measurements in SCD.

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使用 ASE 和 TRUST 方法比较镰状细胞病患者和健康对照组的脑氧萃取分数。

氧萃取分数（OEF）是大脑代谢压力的一种假定生物标志物，它的异常可能表明镰状细胞病（SCD）患者的氧输送受到影响，容易缺血。使用非对称自旋回波（ASE）磁共振方法在整个大脑的组织水平观察到 OEF 升高，而使用不同校准模型的 T2- 松弛-自旋下标记（TRUST）磁共振成像方法从上矢状窦（SSS）发现了不同的全局 OEF。在本研究中，我们旨在比较 SCD 患者和健康对照组 SSS 引流区的平均 ASE-OEF 和 SSS 的 TRUST-OEF。74 名参与者（SCD：49 人；对照组：25 人）接受了脑磁共振成像检查。TRUST-OEF 采用 Lu-bovine、Bush-HbA 和 Li-Bush-HbS 模型进行量化。使用 Lu-bovine 或 Bush-HbA 模型控制血细胞比容后，健康对照组的 ASE-OEF 和 TRUST-OEF 显著相关。但是，在使用 Bush-HbA 或 Li-Bush-HbS 模型的 SCD 患者中，ASE-OEF 和 TRUST-OEF 之间没有关联。可能的解释包括：SSS 中脑组织空间容积平均氧合与血流加权容积平均氧合不一致，或 SCD 中校准不理想。需要进一步开展工作来完善和验证 SCD 中的无创 MR OEF 测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.