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Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change. 对 QSM+qBOLD(或 QQ)检测生理变化中氧萃取分数(OEF)升高的灵敏度进行评估。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-05 DOI: 10.1177/0271678X241298584
Praveena Elanghovan, Thanh Nguyen, Pascal Spincemaille, Ajay Gupta, Yi Wang, Junghun Cho

The study investigated the sensitivity of a novel MRI-based OEF mapping, quantitative susceptibility mapping plus quantitative blood oxygen level-dependent imaging (QSM+qBOLD or QQ), to physiological changes, particularly increased oxygen extraction fraction (OEF) by using hyperventilation as a vasoconstrictive stimulus. While QQ's sensitivity to decreased OEF during hypercapnia has been demonstrated, its sensitivity to increased OEF levels, crucial for cerebrovascular disorders like vascular dementia and Parkinson's disease, remains unexplored. In comparison with a previous QSM-based OEF, we evaluated QQ's sensitivity to high OEF values. MRI data were obtained from 11 healthy subjects during resting state (RS) and hyperventilation state (HV) using a 3 T MRI with a three-dimensional multi-echo gradient echo sequence (mGRE) and arterial spin labeling (ASL). Region of interest (ROI) analysis and paired t-tests were used to compare OEF, CMRO2 and CBF between QQ and QSM. Similar to QSM, QQ showed higher OEF during HV compared to RS: in cortical gray matter, QQ-OEF and QSM-OEF was 36.4±4.7% and 35.3±12.5% at RS and 45.0±11.6% and 45.0±14.8% in HV, respectively. These findings demonstrate QQ's ability to detect physiological changes and suggest its potential in studying brain metabolism in neurological disorders.

这项研究通过使用过度通气作为血管收缩刺激,研究了基于磁共振成像的新型OEF图谱--定量易感图谱加定量血氧水平依赖性成像(QSM+qBOLD或QQ)--对生理变化的敏感性,特别是对氧提取分数(OEF)增加的敏感性。虽然 QQ 对高碳酸血症时 OEF 降低的敏感性已得到证实,但其对 OEF 水平升高的敏感性(这对血管性痴呆和帕金森病等脑血管疾病至关重要)仍有待探索。与之前基于 QSM 的 OEF 相比,我们评估了 QQ 对高 OEF 值的敏感性。我们使用三维多回波梯度回波序列(mGRE)和动脉自旋标记(ASL)的 3 T MRI 获取了 11 名健康受试者在静息状态(RS)和过度换气状态(HV)下的 MRI 数据。采用感兴趣区(ROI)分析和配对 t 检验比较了 QQ 和 QSM 的 OEF、CMRO2 和 CBF。与 QSM 相似,与 RS 相比,QQ 在 HV 期间显示出更高的 OEF:在皮层灰质中,QQ-OEF 和 QSM-OEF 在 RS 中分别为 36.4 ± 4.7% 和 35.3 ± 12.5%,在 HV 中分别为 45.0 ± 11.6% 和 45.0 ± 14.8%。这些发现证明了 QQ 检测生理变化的能力,并表明其在研究神经系统疾病的脑代谢方面具有潜力。
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引用次数: 0
Impact of intracranial hypertension and cerebral perfusion pressure on spreading depolarization. 颅内高压和脑灌注压对展期去极化的影响
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-05 DOI: 10.1177/0271678X241296799
Takuma Nishimoto, Fumiaki Oka, Takao Inoue, Hiroshi Moriyama, Reo Kawano, Michiyasu Suzuki, David Y Chung, Cenk Ayata, Hideyuki Ishihara

Spreading depolarization (SD) develops after stroke and traumatic brain injury and may contribute to secondary brain damage. These diseases are often accompanied by intracranial hypertension, but little is known about the effects of intracranial pressure (ICP) on SD. Here, we study the effect of increased ICP on hemodynamic and metabolic response to SD in rats. SDs were triggered at different ICPs and cerebral perfusion pressures (CPP). The regional cerebral blood flow (rCBF), partial pressure of brain tissue oxygen (PbtO2), cerebral extracellular glucose and lactate concentrations were recorded. Fluoro-Jade staining was used to quantify neuronal injury in cortex. At high ICP (50 mmHg) with low CPP (30 mmHg), rCBF and PbtO2 were monophasically decreased in contrast to a monophasically increased pattern under normal conditions. Neuronal death increased in both hemispheres but much more on the side where SDs were triggered. At high ICP (50 mmHg) with normal CPP (70 mmHg), CBF and metabolism during SD did not differ from baseline, and neuronal death did not increase even on the side of SD induction. These data suggest that maintaining CPP at 70 mmHg, even when the ICP is as high as 50 mmHg, preserves normal blood flow and metabolism during SD events and prevents neuronal degeneration.

脑卒中和脑外伤后会出现扩展性去极化(SD),并可能导致继发性脑损伤。这些疾病通常伴有颅内高压,但人们对颅内压(ICP)对 SD 的影响知之甚少。在此,我们研究了ICP升高对大鼠血液动力学和新陈代谢对SD反应的影响。在不同的 ICP 和脑灌注压 (CPP) 下触发 SD。记录区域脑血流量(rCBF)、脑组织氧分压(PbtO2)、脑细胞外葡萄糖和乳酸浓度。荧光玉染色用于量化大脑皮层的神经元损伤。在高 ICP(50 mmHg)和低 CPP(30 mmHg)条件下,rCBF 和 PbtO2 呈单相降低,而正常条件下则呈单相升高。两个半球的神经元死亡都增加了,但触发 SD 的一侧增加得更多。在高 ICP(50 mmHg)和正常 CPP(70 mmHg)条件下,SD 期间的 CBF 和新陈代谢与基线没有差异,即使在诱发 SD 的一侧,神经元死亡也没有增加。这些数据表明,即使当 ICP 高达 50 mmHg 时,将 CPP 保持在 70 mmHg,也能在 SD 事件期间保持正常的血流和新陈代谢,并防止神经元变性。
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引用次数: 0
Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnoea. 视网膜微血管表型可追踪阻塞性睡眠呼吸暂停患者的小血管疾病负担和 CPAP 治疗效果。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-02 DOI: 10.1177/0271678X241291958
Ylenia Giarratano, Elizabeth A Hill, Charlene Hamid, Stewart Wiseman, Calum Gray, Francesca M Chappell, Roberto Duarte Coello, Maria C Valdés-Hernández, Lucia Ballerini, Michael S Stringer, Michael J Thrippleton, Daniela Jaime Garcia, Xiaodi Liu, William Hewins, Yajun Cheng, Sandra E Black, Andrew Lim, Rosa Sommer, Joel Ramirez, Bradley J MacIntosh, Rosalind Brown, Fergus Doubal, Tom MacGillivray, Joanna M Wardlaw, Renata Riha, Miguel O Bernabeu

Optical coherence tomography angiography (OCT-A) retinal imaging enables in vivo visualization of the retinal microvasculature that is developmentally related to the brain and can offer insight on cerebrovascular health. We investigated retinal phenotypes and neuroimaging markers of small vessel disease (SVD) in individuals with obstructive sleep apnoea (OSA). We enrolled 44 participants (mean age 50.1 ± SD 9.1 years) and performed OCT-A imaging before and after continuous positive airway pressure (CPAP) therapy. Pre-treatment analyses using a generalized estimating equations model adjusted for relevant covariates, revealed perivascular spaces (PVS) volume in basal ganglia associated with greater foveal vessel density (fVD) (p-value < 0.001), and smaller foveal avascular zone area (p-value = 0.01), whereas PVS count in centrum semiovale associated with lower retinal vessel radius (p-value = 0.02) and higher vessel tortuosity (p-value = 0.01). A reduction in retinal vessel radius was also observed with increased OSA severity (p-value = 0.05). Post-treatment analyses showed greater CPAP usage was associated with a decrease in fVD (p-value = 0.02), and increased retinal vessel radius (p-value = 0.01). The findings demonstrate for the first time the potential use of OCT-A to monitor CPAP treatment and its possible impact on both retinal and brain vascular health.

光学相干断层血管成像(OCT-A)视网膜成像技术能够在体内观察到与大脑发育相关的视网膜微血管,并能深入了解脑血管的健康状况。我们研究了阻塞性睡眠呼吸暂停(OSA)患者的视网膜表型和小血管疾病(SVD)的神经影像标记。我们招募了 44 名参与者(平均年龄 50.1 ± SD 9.1 岁),并在持续气道正压(CPAP)治疗前后进行了 OCT-A 成像。使用广义估计方程模型进行治疗前分析,并对相关协变量进行调整,结果显示基底节的血管周围空间(PVS)体积与更大的眼窝血管密度(fVD)相关(p值为0.05)。
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引用次数: 0
Cerebral blood flow regulation and cognitive performance in hypertension. 高血压患者的脑血流调节和认知能力。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 Epub Date: 2024-05-13 DOI: 10.1177/0271678X241254680
Ana Monteiro, Pedro Castro, Gilberto Pereira, Carmen Ferreira, Jorge Polonia, Mariana Lobo, Elsa Azevedo

We examined the relation between transcranial Doppler (TCD) markers of cerebral blood flow regulation and cognitive performance in hypertension (HT) patients to evaluate the predictive value of these markers for cognitive decline. We assessed dynamic cerebral autoregulation (dCA), vasoreactivity to carbon dioxide, and neurovascular coupling (NVC) in the middle (MCA) and posterior (PCA) cerebral arteries of 52 patients. Neuropsychological evaluation included the Montreal Cognitive Assessment and tests covering attention, executive function, processing speed, and memory. Notably, reduced rate time in the PCA significantly predicted better processing speed (p = 0.003). Furthermore, reduced overshoot systolic cerebral blood velocity in the PCA and reduced phase in the VLF range in the MCA (p = 0.021 and p = 0.017, respectively) significantly predicted better memory. Intriguingly, enhanced dCA in the MCA predicted poorer memory performance, while reduced NVC in the PCA predicted both superior processing speed and memory performance. These findings suggest that HT-induced changes in cerebral hemodynamics impact cognitive performance. Further research should verify these observations and elucidate whether these changes represent adaptive responses or neurovascular inefficiency. TCD markers might provide insights into HT-related cognitive decline.

我们研究了高血压(HT)患者脑血流调节的经颅多普勒(TCD)标记物与认知能力之间的关系,以评估这些标记物对认知能力下降的预测价值。我们对 52 名患者的大脑中动脉(MCA)和大脑后动脉(PCA)的动态脑自动调节(dCA)、对二氧化碳的血管反应性和神经血管耦合(NVC)进行了评估。神经心理学评估包括蒙特利尔认知评估和涵盖注意力、执行功能、处理速度和记忆力的测试。值得注意的是,减少 PCA 的速率时间可显著提高处理速度(p = 0.003)。此外,PCA 过冲收缩期脑血流速度的降低和 MCA VLF 范围内相位的降低(分别为 p = 0.021 和 p = 0.017)可显著预示更好的记忆力。耐人寻味的是,MCA 中 dCA 的增强预示着记忆力较差,而 PCA 中 NVC 的降低则预示着处理速度和记忆力都较好。这些发现表明,高温诱导的脑血流动力学变化会影响认知能力。进一步的研究应该验证这些观察结果,并阐明这些变化是代表适应性反应还是神经血管效率低下。TCD 标记可能有助于深入了解与 HT 相关的认知能力下降。
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引用次数: 0
Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy. 核磁共振成像上的白质微结构损伤与荷兰型脑淀粉样血管病的病情严重程度有关。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 Epub Date: 2024-06-17 DOI: 10.1177/0271678X241261771
Ingeborg Rasing, Naomi Vlegels, Manon R Schipper, Sabine Voigt, Emma A Koemans, Kanishk Kaushik, Rosemarie van Dort, Thijs W van Harten, Alberto De Luca, Ellis S van Etten, Erik W van Zwet, Mark A van Buchem, Huub Am Middelkoop, Geert Jan Biessels, Gisela M Terwindt, Matthias Jp van Osch, Marianne Aa van Walderveen, Marieke Jh Wermer

Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers and cognitive symptoms. We included (pre)symptomatic D-CAA mutation-carriers and calculated PSMD from diffusion-MRI data. Associations between PSMD-levels, cognitive performance and CAA-related MRI-markers were assessed with linear regression models. We included 59 participants (25/34 presymptomatic/symptomatic; mean age 39/58 y). PSMD-levels increased with disease severity and were higher in symptomatic D-CAA mutation-carriers (median [range] 4.90 [2.77-9.50]mm2/s × 10-4) compared with presymptomatic mutation-carriers (2.62 [1.96-3.43]mm2/s × 10-4) p = <0.001. PSMD was positively correlated with age, CAA-SVD burden on MRI (adj.B [confidence interval] = 0.42 [0.16-0.67], p = 0.002), with number of cerebral microbleeds (adj.B = 0.30 [0.08-0.53], p = 0.009), and with both deep (adj.B = 0.46 [0.22-0.69], p = <0.001) and periventricular (adj.B = 0.38 [0.13-0.62], p = 0.004) white matter hyperintensities. Increasing PSMD was associated with decreasing Trail Making Test (TMT)-A performance (B = -0.42 [-0.69-0.14], p = 0.04. In D-CAA mutation-carriers microstructural white matter damage is associated with disease phase, CAA burden on MRI and cognitive impairment as reflected by a decrease in information processing speed. PSMD, as a global measure of alterations to the white matter microstructure, may be a useful tool to monitor disease progression in CAA.

骨架化平均弥散度峰值宽度(PSMD)是一种新兴的基于弥散成像的标记,用于研究白质微观结构的早期微妙改变。我们评估了荷兰型遗传性 CAA(D-CAA)中 PSMD 的临床连续性及其与其他 CAA 相关 MRI 标记和认知症状的关联。我们纳入了有症状的D-CAA突变携带者,并根据弥散磁共振成像数据计算了PSMD。通过线性回归模型评估了 PSMD 水平、认知表现和 CAA 相关 MRI 标志物之间的关联。我们共纳入了 59 名参与者(25/34 为无症状/有症状;平均年龄为 39/58 岁)。有症状的 D-CAA 基因突变携带者(中位数 [范围] 4.90 [2.77-9.50]mm2/s × 10-4)与无症状的基因突变携带者(2.62 [1.96-3.43]mm2/s × 10-4)相比,PSMD 水平随着疾病严重程度的增加而升高。
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引用次数: 0
Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat - A multimodal and comprehensive model. 大鼠心脏骤停后脑损伤和神经功能障碍的演变--一个多模式综合模型。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 Epub Date: 2024-05-21 DOI: 10.1177/0271678X241255599
Carlo Perego, Francesca Fumagalli, Francesca Motta, Marianna Cerrato, Edoardo Micotti, Davide Olivari, Daria De Giorgio, Giulia Merigo, Angelo Di Clemente, Alessandra Mandelli, Gianluigi Forloni, Luigi Cervo, Roberto Furlan, Roberto Latini, Robert W Neumar, Giuseppe Ristagno

Cardiac arrest (CA) is one of the leading causes of death worldwide. Due to hypoxic ischemic brain injury, CA survivors may experience variable degrees of neurological dysfunction. This study, for the first time, describes the progression of CA-induced neuropathology in the rat. CA rats displayed neurological and exploratory deficits. Brain MRI revealed cortical and striatal edema at 3 days (d), white matter (WM) damage in corpus callosum (CC), external capsule (EC), internal capsule (IC) at d7 and d14. At d3 a brain edema significantly correlated with neurological score. Parallel neuropathological studies showed neurodegeneration, reduced neuronal density in CA1 and hilus of hippocampus at d7 and d14, with cells dying at d3 in hilus. Microgliosis increased in cortex (Cx), caudate putamen (Cpu), CA1, CC, and EC up to d14. Astrogliosis increased earlier (d3 to d7) in Cx, Cpu, CC and EC compared to CA1 (d7 to d14). Plasma levels of neurofilament light (NfL) increased at d3 and remained elevated up to d14. NfL levels at d7 correlated with WM damage. The study shows the consequences up to 14d after CA in rats, introducing clinically relevant parameters such as advanced neuroimaging and blood biomarker useful to test therapeutic interventions in this model.

心脏骤停(CA)是导致全球死亡的主要原因之一。由于缺氧缺血性脑损伤,心脏骤停幸存者可能会出现不同程度的神经功能障碍。本研究首次描述了 CA 引起的大鼠神经病理学进展。CA 大鼠表现出神经和探索功能障碍。脑磁共振成像显示,大鼠3天(d)时皮质和纹状体水肿,7天(d7)和14天(d14)时胼胝体(CC)、外囊(EC)和内囊(IC)的白质(WM)受损。d3 脑水肿与神经系统评分明显相关。同时进行的神经病理学研究显示,d7和d14时,神经变性、海马CA1和后部神经元密度降低,d3时后部细胞死亡。皮质(Cx)、尾状核丘脑(Cpu)、CA1、CC和EC的小胶质细胞增多,直至d14。Cx、Cpu、CC和EC的星形胶质细胞增多(d3至d7)早于CA1(d7至d14)。血浆中的神经丝光(NfL)水平在d3时升高,并在d14时保持升高。d7 的 NfL 水平与 WM 损伤相关。该研究显示了大鼠CA发生后14天内的后果,引入了临床相关参数,如先进的神经影像学和血液生物标记物,有助于在该模型中测试治疗干预措施。
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引用次数: 0
Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins. 基底节中扩大的血管周围空间与动脉而非静脉有关。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 Epub Date: 2024-06-11 DOI: 10.1177/0271678X241260629
Jan Oltmer, Hendrik Mattern, Julia Beck, Renat Yakupov, Steven M Greenberg, Jaco Jm Zwanenburg, Tine Arts, Emrah Düzel, Susanne J van Veluw, Stefanie Schreiber, Valentina Perosa

Enlarged perivascular spaces (EPVS) are common in cerebral small vessel disease (CSVD) and have been identified as a marker of dysfunctional brain clearance. However, it remains unknown if the enlargement occurs predominantly around arteries or veins. We combined in vivo ultra-high-resolution MRI and histopathology to investigate the spatial relationship of veins and arteries with EPVS within the basal ganglia (BG). Furthermore, we assessed the relationship between the EPVS and measures of blood-flow (blood-flow velocity, pulsatility index) in the small arteries of the BG. Twenty-four healthy controls, twelve non-CAA CSVD patients, and five probable CAA patients underwent a 3 tesla [T] and 7T MRI-scan, and EPVS, arteries, and veins within the BG were manually segmented. Furthermore, the scans were co-registered. Six autopsy-cases were also assessed. In the BG, EPVS were significantly closer to and overlapped more frequently with arteries than with veins. Histological analysis showed a higher proportion of BG EPVS surrounding arteries than veins. Finally, the pulsatility index of BG arteries correlated with EPVS volume. Our results are in line with previous works and establish a pathophysiological relationship between arteries and EPVS, contributing to elucidating perivascular clearance routes in the human brain.

血管周围间隙(EPVS)增大在脑小血管疾病(CSVD)中很常见,已被确定为脑清除功能障碍的标志物。然而,这种扩大主要发生在动脉还是静脉周围仍是未知数。我们结合活体超高分辨率磁共振成像和组织病理学研究了基底节(BG)内静脉和动脉与 EPVS 的空间关系。此外,我们还评估了 EPVS 与基底节小动脉血流测量值(血流速度、搏动指数)之间的关系。24 名健康对照者、12 名非 CAA CSVD 患者和 5 名疑似 CAA 患者接受了 3 特斯拉 [T] 和 7T MRI 扫描,并对 BG 内的 EPVS、动脉和静脉进行了人工分割。此外,还对扫描结果进行了联合注册。此外,还对六例尸检病例进行了评估。在 BG 中,EPVS 与动脉的距离和重叠频率明显高于静脉。组织学分析显示,围绕动脉的 BG EPVS 比例高于静脉。最后,BG 动脉的搏动指数与 EPVS 的体积相关。我们的研究结果与之前的研究结果一致,建立了动脉和 EPVS 之间的病理生理学关系,有助于阐明人脑血管周围的清除途径。
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引用次数: 0
Static autoregulation in humans. 人类的静态自我调节。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 Epub Date: 2023-11-07 DOI: 10.1177/0271678X231210430
Yufan Wang, Stephen J Payne

The process by which cerebral blood flow (CBF) remains approximately constant in response to short-term variations in arterial blood pressure (ABP) is known as cerebral autoregulation. This classic view, that it remains constant over a wide range of ABP, has however been challenged by a growing number of studies. To provide an updated understanding of the static cerebral pressure-flow relationship and to characterise the autoregulation curve more rigorously, we conducted a comprehensive literature research. Results were based on 143 studies in healthy individuals aged 18 to 65 years. The mean sensitivities of CBF to changes in ABP were found to be 1.47 ± 0.71%/% for decreased ABP and 0.37 ± 0.38%/% for increased ABP. The significant difference in CBF directional sensitivity suggests that cerebral autoregulation appears to be more effective in buffering increases in ABP than decreases in ABP. Regression analysis of absolute CBF and ABP identified an autoregulatory plateau of approximately 20 mmHg (ABP between 80 and 100 mmHg), which is much smaller than the widely accepted classical view. Age and sex were found to have no effect on autoregulation strength. This data-driven approach provides a quantitative method of analysing static autoregulation that can be easily updated as more experimental data become available.

大脑血流量(CBF)对动脉血压(ABP)的短期变化保持大致恒定的过程被称为大脑自动调节。然而,越来越多的研究对这一经典观点提出了质疑,即它在广泛的ABP中保持不变。为了提供对静态脑压-流量关系的最新理解,并更严格地描述自动调节曲线,我们进行了一项全面的文献研究。结果基于143项针对18至65岁健康人的研究 年。CBF对ABP变化的平均敏感性为1.47 ± ABP降低为0.71%/% ± ABP增加0.38%/%。CBF方向敏感性的显著差异表明,大脑自动调节在缓冲ABP增加方面似乎比ABP减少更有效。绝对CBF和ABP的回归分析确定了大约20的自动调节平台 mmHg(ABP在80和100之间 mmHg),这比广泛接受的经典观点小得多。年龄和性别对自身调节强度没有影响。这种数据驱动的方法提供了一种分析静态自动调节的定量方法,随着更多实验数据的可用,该方法可以很容易地更新。
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引用次数: 0
High-resolution vasomotion analysis reveals novel arteriole physiological features and progressive modulation of cerebral vascular networks by stroke. 高分辨率血管运动分析揭示了新的动脉生理特征以及中风对脑血管网络的渐进式调节。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 Epub Date: 2024-05-31 DOI: 10.1177/0271678X241258576
Yi-Yi Zhang, Jin-Ze Li, Hui-Qi Xie, Yu-Xiao Jin, Wen-Tao Wang, Bingrui Zhao, Jie-Min Jia

Spontaneous cerebral vasomotion, characterized by ∼0.1 Hz rhythmic contractility, is crucial for brain homeostasis. However, our understanding of vasomotion is limited due to a lack of high-precision analytical methods to determine single vasomotion events at basal levels. Here, we developed a novel strategy that integrates a baseline smoothing algorithm, allowing precise measurements of vasodynamics and concomitant Ca2+ dynamics in mouse cerebral vasculature imaged by two-photon microscopy. We identified several previously unrecognized vasomotion properties under different physiological and pathological conditions, especially in ischemic stroke, which is a highly harmful brain disease that results from vessel occlusion. First, the dynamic characteristics between SMCs Ca2+ and corresponding arteriolar vasomotion are correlated. Second, compared to previous diameter-based estimations, our radius-based measurements reveal anisotropic vascular movements, enabling a more precise determination of the latency between smooth muscle cell (SMC) Ca2+ activity and vasoconstriction. Third, we characterized single vasomotion event kinetics at scales of less than 4 seconds. Finally, following pathological vasoconstrictions induced by ischemic stroke, vasoactive arterioles entered an inert state and persisted despite recanalization. In summary, we developed a highly accurate technique for analyzing spontaneous vasomotion, and our data suggested a potential strategy to reduce stroke damage by promoting vasomotion recovery.

自发性脑血管运动的特点是~0.1赫兹的节律性收缩,它对大脑的平衡至关重要。然而,由于缺乏高精度的分析方法来确定基础水平的单次血管运动事件,我们对血管运动的了解十分有限。在这里,我们开发了一种整合了基线平滑算法的新策略,可以精确测量双光子显微镜成像的小鼠脑血管中的血管动力学和伴随的 Ca2+ 动态。我们发现了在不同的生理和病理条件下,尤其是在缺血性中风这种由血管闭塞导致的危害性极大的脑部疾病中,几种以前未曾认识到的血管运动特性。首先,SMC Ca2+ 与相应的动脉血管运动之间的动态特性是相关的。其次,与之前基于直径的估计相比,我们基于半径的测量揭示了各向异性的血管运动,从而能更精确地确定平滑肌细胞(SMC)Ca2+ 活动与血管收缩之间的潜伏期。第三,我们以小于 4 秒的尺度描述了单个血管运动事件的动力学特征。最后,在缺血性中风诱发病理性血管收缩后,血管活性动脉血管进入惰性状态,并在再通后仍持续存在。总之,我们开发了一种高度精确的自发性血管运动分析技术,我们的数据提出了一种通过促进血管运动恢复来减少中风损伤的潜在策略。
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引用次数: 0
Shifting concepts of autoregulation: Commentary to 'Static autoregulation in humans'. 自动调节概念的转变:对 "人类静态自动调节 "的评论。
IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI: 10.1177/0271678X241254676
Jurgen Ahr Claassen

Advances in imaging techniques have transformed our understanding of cerebral autoregulation. Older imaging techniques provided measurements of cerebral blood flow (CBF) that reflected the average CBF over a window of 10-20 minutes. A key finding, dating back to 1959, was that CBF remained more or less stable over a remarkably wide range of changes in blood pressure. Modern techniques can measure changes in CBF within the time frame of a heartbeat. They have revealed, paradoxically, a remarkable instability of CBF. This commentary attempts to reconcile these seemingly contradictory observations.

成像技术的进步改变了我们对大脑自动调节的认识。较早的成像技术提供的脑血流(CBF)测量值反映了 10-20 分钟内的平均 CBF。一个可追溯到 1959 年的重要发现是,CBF 在血压变化的极大范围内基本保持稳定。现代技术可以在心跳的时间范围内测量 CBF 的变化。矛盾的是,这些技术揭示了 CBF 的显著不稳定性。本评论试图调和这些看似矛盾的观察结果。
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引用次数: 0
期刊
Journal of Cerebral Blood Flow and Metabolism
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