The Effect of Vitamin D Supplementation to Parameter of Sarcopenia in Elderly People: a Systematic Review and Meta-Analysis.

IF 1.6 Q4 GERIATRICS & GERONTOLOGY Canadian Geriatrics Journal Pub Date : 2024-03-01 DOI:10.5770/cgj.27.694

Novira Widajanti, Usman Hadi, Soebagijo Adi Soelistijo, Noer Halimatus Syakdiyah, Roudhona Rosaudyn, Hendy Bhaskara Perdana Putra

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Abstract

Background: Vitamin D plays an essential role in promoting skeletal muscle metabolism. Several studies show that vitamin D may help the elderly prevent sarcopenia. Nevertheless, the outcome remains debatable. Our meta-analysis aimed to summarize the effect of vitamin D supplementation on sarcopenia-related parameters.

Methods: We searched PubMed, Cochrane, Springer, SAGE Journals, and Scopus abstracts on 10th December 2021 for relevant studies. We included articles that studied the effect of vitamin D on muscle mass, muscle strength, and physical performance. The aim was to measure the muscle mass, muscle strength, and physical performance both at baseline and at the end of the intervention.

Results: A total of 6,628 participants from 35 studies were included. Most of the studies used oral vitamin D, whereas only one study used intramuscular injection. The effect of vitamin D supplementation showed no effect on appendicular skeletal muscle mass (SMD = .05 [95% CI, .33 - .44], p = .79). Regarding muscle strength, vitamin D supplementation did not have a significant effect on muscle strength which is handgrip strength (p = .26). Respecting physical performance, vitamin D supplementation did not affect TUG (Timed Up and Go) (p = .45).

Conclusions: Vitamin D supplementation had minimal effect on sarcopenia-related parameters. Further research into understanding the role of Vitamin D in preventing the progressivity of sarcopenia still needs to be explored.

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补充维生素 D 对老年人肌肉疏松症参数的影响：系统综述与 Meta 分析。

背景：维生素 D 在促进骨骼肌新陈代谢方面发挥着重要作用。多项研究表明，维生素 D 可帮助老年人预防肌肉疏松症。然而，其结果仍有待商榷。我们的荟萃分析旨在总结维生素 D 补充剂对肌肉疏松症相关参数的影响：我们于 2021 年 12 月 10 日在 PubMed、Cochrane、Springer、SAGE 期刊和 Scopus 摘要中搜索了相关研究。我们纳入了研究维生素 D 对肌肉质量、肌肉力量和身体表现影响的文章。目的是测量基线和干预结束时的肌肉质量、肌肉力量和体能表现：结果：共纳入了 35 项研究的 6628 名参与者。大多数研究使用口服维生素 D，只有一项研究使用肌肉注射。维生素 D 补充剂对骨骼肌质量没有影响（SMD = .05 [95% CI, .33 - .44], p = .79）。在肌肉力量方面，补充维生素 D 对肌肉力量（即手握力）没有显著影响（p = .26）。在体能方面，补充维生素 D 对 TUG（计时起立和走动）没有影响（p = .45）：结论：补充维生素 D 对肌肉疏松症相关参数的影响微乎其微。我们仍需进一步研究维生素 D 在防止肌肉疏松症恶化方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian Geriatrics Journal Nursing-Gerontology

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The Canadian Geriatrics Journal (CGJ) is a peer-reviewed publication that is a home for innovative aging research of a high quality aimed at improving the health and the care provided to older persons residing in Canada and outside our borders. While we gratefully accept submissions from researchers outside our country, we are committed to encouraging aging research by Canadians. The CGJ is targeted to family physicians with training or an interest in the care of older persons, specialists in geriatric medicine, geriatric psychiatrists, and members of other health disciplines with a focus on gerontology.