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Physical, Psychological, Cognitive and Social Frailty Domains in Community-Dwelling Adults Aged 45-85: a Cross-sectional Analysis of the Canadian Longitudinal Study on Aging (CLSA). 45-85岁社区居民的生理、心理、认知和社会脆弱领域:加拿大老龄化纵向研究的横断面分析(里昂证券)。
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.872
Lauren E Griffith, Graciela Muniz Terrera, Edwin van den Heuvel, Jayati Khattar, David B Hogan, Megan O'Connell, Mélanie Levasseur, Parminder Raina

Background: Reported estimates of frailty prevalence vary considerably. At least partially attributable to differences in the conceptualization of frailty used, a better understanding of the inter-relationships among frailty domains could clarify contributors to the noted heterogeneity.

Methods: A global frailty index (FI) created from baseline data on 30,097 Canadian Longitudinal Study on Aging comprehensive cohort participants was used to define physical, psychological, cognitive, and social domain-specific FIs. These were divided into quintiles with the highest 20% (Q5) representing the frailest participants. Logistic regression was used to estimate the associations between age group and biological sex with domain-specific FIs in unadjusted and adjusted (income, smoking status, nutritional risk, physical activity, social participation, interaction between sex and age group) models. The association between Q5 membership among the frailty domains was estimated using polychoric correlation coefficients.

Results: The prevalence of physical and cognitive frailty increased with age, but psychological frailty decreased, especially in males. Social frailty showed gradual increases with age in females that were only evident in the oldest age group (75-85) among men. The age-groups*sex interaction p value was p<.001 for social. Polychoric correlations were highest between the psychological/physical and psychological/social domains, and decreased with increasing age for all combinations.

Conclusion: We found that domain-specific frailty prevalences differed by age group and sex with low associations among frailty domains, particularly at older ages. Understanding the evolution of these findings could be instrumental in developing tailored interventions to prevent frailty or modify its trajectory.

背景:报告中对虚弱患病率的估计差异很大。至少部分归因于脆弱性概念的不同,更好地理解脆弱性领域之间的相互关系可以澄清引起注意的异质性的因素。方法:从30,097名加拿大老龄化纵向研究综合队列参与者的基线数据创建的全球衰弱指数(FI)用于定义身体,心理,认知和社会领域特定的FI。这些被分成五分之一,最高的20% (Q5)代表最脆弱的参与者。在未调整和调整的(收入、吸烟状况、营养风险、体育活动、社会参与、性别和年龄组之间的相互作用)模型中,使用Logistic回归来估计年龄和生理性别与领域特定FIs之间的关联。利用多重相关系数估计脆弱结构域间Q5隶属关系的相关性。结果:随着年龄的增长,身体和认知虚弱的患病率增加,而心理虚弱的患病率下降,尤其是在男性中。随着年龄的增长,女性的社会脆弱性逐渐增加,而男性只有在年龄最大的年龄组(75-85岁)中才明显。结论:我们发现不同年龄和性别的特定脆弱域患病率存在差异,脆弱域之间的相关性较低,特别是在老年。了解这些发现的演变可能有助于开发量身定制的干预措施,以预防脆弱或改变其轨迹。
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引用次数: 0
Experiences and Perspectives of Caregivers of Francophone Older Adults Accessing Community Health Services in Toronto: an Exploratory Qualitative Study. 多伦多法语老年人护理人员获得社区卫生服务的经验与展望:一项探索性质的研究。
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.861
Elizabeth K Boyd, Idrissa Beogo, Barbara Liu, Fabien Schneider, Mireille Norris

Background: Canada is a bilingual country; however, outside of Quebec, health-care services are predominantly offered in English. With the increasing older adult population and stretched health-care resources, Francophone older adults may face significant challenges in accessing care due to their linguistic minority status. This study explores the experiences of caregivers of Francophone older adults in the Greater Toronto Area (GTA).

Methods: Using a convenience sampling strategy, caregivers of patients who had undergone geriatric assessment at the Centre Francophone du Grand Toronto (CFGT) were recruited. Participants underwent 45-minute, semi-structured interviews and completed demographic questionnaires. Three independent reviewers conducted qualitative content analysis of the interview transcripts, using the socioecological model of health and NVivo12.

Results: Nine participants were primarily female (n=5), with age ranges of 40-49 (n=2), 50-59 (n=3), and 60+ (n=4). They originated from North America (n=5), Africa (n=3), and the Middle East (n=1); about half preferred English over French. Thematic analysis identified three key themes: 1) Barriers Accessing Health Care in the French Language; 2) The Need for Interpreter Support; 3) Importance of Comprehensive Francophone Community Services.

Conclusions: Despite the presence of organizations (e.g., CFGT), this study reveals a significant gap in French-language services for older adults in the GTA, leading to increased challenges for their caregivers. Due to linguistic barriers, caregivers must act as interpreters to mitigate the risks associated with miscommunication and potentially worse health outcomes. Addressing these issues requires increasing bilingual health-care providers, enhancing funding for Francophone community services, and improving support systems (e.g., interpreters).

背景:加拿大是一个双语国家;然而,在魁北克以外,保健服务主要以英语提供。随着老年人口的增加和医疗保健资源的紧张,讲法语的老年人由于其语言上的少数民族地位,在获得护理方面可能面临重大挑战。本研究探讨了在大多伦多地区(GTA)讲法语的老年人的护理经验。方法:采用方便抽样策略,招募在大多伦多法语中心(CFGT)接受老年评估的患者的护理人员。参与者接受了45分钟的半结构化访谈,并完成了人口调查问卷。三位独立审稿人使用健康社会生态模型和NVivo12对访谈记录进行了定性内容分析。结果:9名参与者主要为女性(n=5),年龄范围为40-49岁(n=2)、50-59岁(n=3)和60岁以上(n=4)。它们来自北美(n=5)、非洲(n=3)和中东(n=1);大约一半的人更喜欢英语而不是法语。专题分析确定了三个关键主题:1)以法语获得保健服务的障碍;2)翻译支持的需求;3)法语社区综合服务的重要性。结论:尽管有组织(如CFGT)的存在,本研究揭示了大多伦多地区老年人法语服务的显著差距,导致他们的照顾者面临更大的挑战。由于语言障碍,护理人员必须充当翻译,以减轻与沟通不端和潜在的更糟糕的健康结果相关的风险。解决这些问题需要增加双语保健提供者,增加对法语社区服务的供资,并改进支助系统(例如口译员)。
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引用次数: 0
Notice of Retraction: Predicting falls among older persons using machine learning [abstract]. 撤回通知:使用机器学习预测老年人跌倒[摘要]。
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01

[This retracts the article DOI: 10.5770/cgj.27.786.].

[本文撤回文章DOI: 10.5770/cgj.27.786]。
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引用次数: 0
Diagnostic Accuracy of Tools to Identify Anxiety Symptoms and Disorders in Persons with Dementia: a Systematic Review Update. 识别痴呆患者焦虑症状和障碍的工具的诊断准确性:系统回顾更新
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.875
Kayla Atchison, Pauline Wu, Dallas Seitz, Jennifer A Watt, Zahra Goodarzi

Limited anxiety tools validated against a diagnostic gold standard in the context of dementia have been identified. A systematic review update was completed to identify publications since 2017 describing tools to detect anxiety in persons with dementia compared to a diagnostic gold standard. The original search strategy was replicated in MEDLINE, Embase, and PsycINFO. Pooled prevalence and diagnostic accuracy estimates were calculated based on three or more studies presenting comparable information from either the original or updated review search. No pooled estimates were calculated in the original review given limited evidence. One study evaluating the Rating Anxiety in Dementia (RAID) scale, Neuropsychiatric Inventory, and Hamilton Anxiety Rating Scale met review inclusion criteria. The pooled prevalence of generalized anxiety disorder (GAD) (n=3, 36.7%, 95% Confidence Interval (CI): 24.3-49.2%) and diagnostic accuracy outcomes for the RAID scale (≥11 cut-off) to detect GAD (n=3, sensitivity: 89%, 95% CI: 78-95%; specificity: 73%, 95% CI: 60-82%) were calculated using data from two studies identified in the original review and the newly included study from the review update. The RAID scale has the most evidence and adequate sensitivity to support its use in identifying anxiety in persons with dementia. Validated tools to detect anxiety in persons with dementia remain understudied.

在痴呆症的背景下,有限的焦虑工具已被确定为诊断金标准。完成了一项系统评价更新,以确定自2017年以来的出版物,这些出版物描述了与诊断金标准相比检测痴呆症患者焦虑的工具。原始的搜索策略在MEDLINE、Embase和PsycINFO中被复制。合并患病率和诊断准确性估计是根据三个或更多的研究计算的,这些研究提供了来自原始或更新的综述搜索的可比信息。由于证据有限,在最初的综述中没有计算汇总估计。一项评估痴呆焦虑评定量表(RAID)、神经精神量表和汉密尔顿焦虑评定量表的研究符合综述纳入标准。广泛性焦虑障碍(GAD)的总患病率(n=3, 36.7%, 95%置信区间(CI): 24.3-49.2%)和检测GAD的RAID量表(临界值≥11)的诊断准确性结果(n=3,敏感性:89%,95% CI: 78-95%;特异性:73%,95% CI: 60-82%)使用原始综述中确定的两项研究和更新综述中新纳入的研究的数据计算。RAID量表有最充分的证据和足够的敏感性来支持它在识别痴呆患者焦虑方面的应用。检测痴呆症患者焦虑的有效工具仍未得到充分研究。
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引用次数: 0
Frailty of Health Care Systems. 卫生保健系统的脆弱性。
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.889
Philip D St John, David B Hogan

Frailty is a state of vulnerability to stressors which has long been a focus of Geriatric Medicine, and is gaining acceptance in other fields. The notion of frailty considers individuals, but many similarities exist between individuals and health care systems (HCS). We have drawn parallels between frail individuals and frail health care systems. We have adapted a commonly used measure of frailty-the "Frailty Phenotype", to measure HCS which are vulnerable to acute and chronic stresses. Finally, we note the "double jeopardy" of frail older adults within frail HCS. Ensuring that HCS remain robust and unlikely to fail should be a priority for health-care policy makers.

脆弱是一种易受压力源影响的状态,长期以来一直是老年医学的焦点,并在其他领域得到认可。脆弱的概念考虑的是个人,但个人和卫生保健系统(HCS)之间存在许多相似之处。我们将体弱多病的个人与脆弱的卫生保健系统相提并论。我们采用了一种常用的脆弱性测量方法——“脆弱性表型”,来测量易受急性和慢性压力影响的HCS。最后,我们注意到虚弱的老年人在虚弱的HCS中的“双重危险”。确保卫生保健服务保持稳健,不可能失败,应是卫生保健政策制定者的优先事项。
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引用次数: 0
Evaluating a Paramedic-Led Fall-Referral Program in Nova Scotia: a Mixed-Methods Study. 评估新斯科舍省护理人员主导的跌倒转诊计划:一项混合方法研究。
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.886
Luke Duignan, Izabelle Opra, Alix Je Carter, Florence Grenapin, Scott McCulloch, Andrew Travers, Jan Jensen, Pan Andreou, Suzanne Baker, Judah Goldstein

Background: Falls in older adults are a worldwide health issue, and lead to high morbidity, mortality, and health-care costs. Paramedics play a unique and important role in post-fall management. The objectives of this study were to measure the frequency with which paramedics made referrals to fall-prevention programs, understand the factors influencing these decisions, and compare outcomes between those who received a referral with those who did not.

Methods: This mixed-methods study evaluated a paramedic fall-referral program in Nova Scotia for older adults with non-transport dispositions after a 911 response. Patient demographics and outcomes were analyzd using a matched cohort approach, while paramedic beliefs regarding the program were explored using The Theory of Planned Behavior.

Results: From 2014 to 2019, a total of 289 referrals were made, and a matched cohort analysis (1:2) found no significant difference in the mean number of fall-related 911 calls in the following 12 months between those who were referred (m=0.31, SD=0.94) and those who were not (m=0.30, SD=1.28). Paramedics acknowledged the importance of fall prevention, but felt a lack of education, loop closure-feedback to the referring paramedic, and patient reluctance to consider the program, were all significant barriers to referral.

Discussion: This study assessed Nova Scotia's paramedic fall-prevention referral program, revealing low referral frequency despite high numbers of fall-related 911 calls, and no significant reduction in relapse 911 calls. Barriers to referral included patient reluctance, poor systematization, and lack of education and feedback.

Conclusion: The study highlights opportunities for improving referral systems, as paramedics play a bigger role in the prevention of age-related health issues such as falls.

背景:老年人跌倒是一个世界性的健康问题,导致高发病率、高死亡率和高保健费用。护理人员在跌倒后的管理中发挥着独特而重要的作用。本研究的目的是测量护理人员转介到预防跌倒项目的频率,了解影响这些决定的因素,并比较接受转介和未接受转介的结果。方法:这项混合方法的研究评估了新斯科舍省的护理人员跌倒转诊计划,该计划适用于911响应后无运输倾向的老年人。使用匹配队列方法分析患者人口统计数据和结果,同时使用计划行为理论探索护理人员对该计划的信念。结果:2014年至2019年,共转诊289例,匹配队列分析(1:2)发现,转诊患者(m=0.31, SD=0.94)与未转诊患者(m=0.30, SD=1.28)在随后的12个月内,与跌倒相关的911平均呼叫数无显著差异。护理人员承认预防跌倒的重要性,但觉得缺乏教育,闭环反馈给转诊护理人员,病人不愿意考虑的方案,都是转诊的重大障碍。讨论:本研究评估了新斯科舍省的护理人员预防跌倒转诊项目,发现尽管与跌倒相关的911电话数量很多,但转诊频率很低,并且复发的911电话没有显著减少。转诊的障碍包括患者不情愿、系统不良、缺乏教育和反馈。结论:这项研究强调了改善转诊系统的机会,因为护理人员在预防与年龄有关的健康问题(如跌倒)方面发挥了更大的作用。
{"title":"Evaluating a Paramedic-Led Fall-Referral Program in Nova Scotia: a Mixed-Methods Study.","authors":"Luke Duignan, Izabelle Opra, Alix Je Carter, Florence Grenapin, Scott McCulloch, Andrew Travers, Jan Jensen, Pan Andreou, Suzanne Baker, Judah Goldstein","doi":"10.5770/cgj.28.886","DOIUrl":"10.5770/cgj.28.886","url":null,"abstract":"<p><strong>Background: </strong>Falls in older adults are a worldwide health issue, and lead to high morbidity, mortality, and health-care costs. Paramedics play a unique and important role in post-fall management. The objectives of this study were to measure the frequency with which paramedics made referrals to fall-prevention programs, understand the factors influencing these decisions, and compare outcomes between those who received a referral with those who did not.</p><p><strong>Methods: </strong>This mixed-methods study evaluated a paramedic fall-referral program in Nova Scotia for older adults with non-transport dispositions after a 911 response. Patient demographics and outcomes were analyzd using a matched cohort approach, while paramedic beliefs regarding the program were explored using <i>The Theory of Planned Behavior</i>.</p><p><strong>Results: </strong>From 2014 to 2019, a total of 289 referrals were made, and a matched cohort analysis (1:2) found no significant difference in the mean number of fall-related 911 calls in the following 12 months between those who were referred (m=0.31, SD=0.94) and those who were not (m=0.30, SD=1.28). Paramedics acknowledged the importance of fall prevention, but felt a lack of education, loop closure-feedback to the referring paramedic, and patient reluctance to consider the program, were all significant barriers to referral.</p><p><strong>Discussion: </strong>This study assessed Nova Scotia's paramedic fall-prevention referral program, revealing low referral frequency despite high numbers of fall-related 911 calls, and no significant reduction in relapse 911 calls. Barriers to referral included patient reluctance, poor systematization, and lack of education and feedback.</p><p><strong>Conclusion: </strong>The study highlights opportunities for improving referral systems, as paramedics play a bigger role in the prevention of age-related health issues such as falls.</p>","PeriodicalId":56182,"journal":{"name":"Canadian Geriatrics Journal","volume":"28 4","pages":"336-342"},"PeriodicalIF":1.2,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cross-Sectional Descriptive Study Using Health Administrative Data to Examine the Characteristics of Older Adults Incurring Delayed Discharge Days for Non-Clinical Reasons During the COVID-19 Pandemic in Alberta, Canada. 一项使用卫生行政数据的横断面描述性研究,研究了加拿大阿尔伯塔省COVID-19大流行期间因非临床原因导致的老年人延迟出院天数的特征。
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.865
Jason Chan, Andrea Gruneir

Background: Our study strived to 1) describe the characteristics of older adults incurring delayed discharge days in Alberta from Apr 01, 2019 to March 31, 2022; 2) examine the prevalence and length of delayed discharge days during the COVID-19 pandemic.

Method: We conducted a cross-sectional descriptive study using provincial health administrative data. We included adults ≥65 discharged from hospital from Apr 01, 2019-Mar 31, 2022 in Alberta and whose hospital stay included at least one delayed discharge day. The demographic characteristics of participants were reported in proportions or mean/median. Study period was divided into pandemic waves (pre-pandemic: Apr 1, 2019-Jan 31, 2020; Wave 1: Feb 1, 2020-Aug 31, 2020; Wave 2: Sept 1, 2020-Feb 14, 2021; Wave 3 and beyond: Feb 15, 2021-Mar 31, 2022). Prevalence of delayed discharge in each wave and their median length of stay (IQR) were reported.

Results: From Apr 01, 2019 to Mar 31, 2022, there were 367,912 hospitalizations among older adults living in Alberta. 3.73% (n=13,717) contained at least one delayed discharge day. The percentage of delayed discharge prior to COVID-19 and during each wave stayed consistent. Wave 3 had the shortest median length of stay (29, IQR 15-51). Wave 2 (45.2%) and Wave 3 (45.3%) had higher proportion of patients requiring maximal assistance on the Activities of Daily Living (ADLs). From pre-COVID to Wave 3, there were increases in the proportions of patients discharged to long term care (36.4% in pre-COVID to 40.8% by Wave 3).

Conclusions: Frequency of delayed discharge hospitalizations was consistent across the pandemic waves. Wave 3 had shorter length of delayed discharge hospitalization. The proportion of patients who were discharged to LTC increased over the course of the pandemic.

背景:本研究旨在1)描述2019年4月1日至2022年3月31日阿尔伯塔省老年人延迟出院天数的特征;2)检查COVID-19大流行期间延迟出院天数的流行率和长度。方法:采用省级卫生行政数据进行横断面描述性研究。我们纳入了阿尔伯塔省2019年4月1日至2022年3月31日期间出院的≥65岁的成年人,他们的住院时间至少包括一天延迟出院日。参与者的人口学特征以比例或平均/中位数报告。研究期间分为大流行波(大流行前:2019年4月1日- 2020年1月31日;波1:2020年2月1日- 2020年8月31日;波2:2020年9月1日- 2021年2月14日;波3及以上:2021年2月15日- 2022年3月31日)。报告每波延迟出院的发生率及其中位住院时间(IQR)。结果:2019年4月1日至2022年3月31日,艾伯塔省有367,912名老年人住院,其中3.73% (n=13,717)至少有1天延迟出院。在COVID-19之前和每波期间延迟出院的百分比保持一致。第3组患者的中位住院时间最短(29,IQR 15-51)。第2波(45.2%)和第3波(45.3%)患者在日常生活活动(ADLs)方面需要最大帮助的比例更高。从covid前到第三波,出院接受长期护理的患者比例有所增加(从covid前的36.4%增加到第三波的40.8%)。结论:延迟出院住院的频率在各大流行波中是一致的。波3延迟出院住院时间较短。在大流行期间,出院至LTC的患者比例有所增加。
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引用次数: 0
Challenges Facing Canadian Long-Term Care Homes and Retirement Homes During the COVID-19 Pandemic. 2019冠状病毒病大流行期间加拿大长期护理院和养老院面临的挑战
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.854
Christine Fahim, Ayaat T Hassan, Keelia Quinn de Launay, Alyson Takaoka, Elikem Togo, Lisa Strifler, Vanessa Bach, Nimitha Paul, Ana Mrazovac, Jessica Firman, Vincenza Gruppuso, Jamie M Boyd, Sharon E Straus

Background: COVID-19 exposed long-standing systemic challenges experienced by congregate settings and created a crisis for long-term care homes (LTCHs) and retirement homes (RHs). This study explored the pandemic-related challenges LTCHs and RHs faced and the strategies they used to mitigate them.

Method: Ninety-one key informant interviews were held with LTCH and RH leadership across 47 homes (33 LTCHs, 14 RHs) in Ontario, Canada from February 2021 to July 2022. Data were analyzed following the framework method.

Results: Findings confirmed evidence of three main challenges. First, leaders were challenged to implement infection prevention and control (IPAC) protocols and measures. Second, leaders required supports to facilitate COVID-19 vaccine access and to promote vaccine acceptance. Finally, LTCH/RH staff experienced well-being and mental health challenges in the face of COVID-19 pressures. Despite widespread attention and efforts to support these congregate settings, challenges persisted over one year into the pandemic.

Conclusions: Our findings reveal a plethora of strategies implemented by homes, with ranging reports of perceived success.

背景:2019冠状病毒病暴露了聚集环境面临的长期系统性挑战,并为长期护理院(LTCHs)和养老院(RHs)造成了危机。本研究探讨了ltch和RHs面临的与大流行相关的挑战以及他们用来缓解这些挑战的策略。方法:从2021年2月至2022年7月,对加拿大安大略省47个家庭(33个LTCH, 14个RHs)的LTCH和RH领导进行了91次关键信息访谈。采用框架法对数据进行分析。结果:研究结果证实了三个主要挑战的证据。首先,领导人面临着实施感染预防和控制(IPAC)协议和措施的挑战。第二,领导人需要支持,以促进COVID-19疫苗获取和促进疫苗接受。最后,面对COVID-19的压力,LTCH/RH工作人员经历了福祉和心理健康方面的挑战。尽管广泛关注并努力支持这些聚集环境,但挑战在大流行一年后仍然存在。结论:我们的研究结果揭示了家庭实施的过多策略,并报告了一系列可感知的成功。
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引用次数: 0
Interventions to Improve Cognitive Outcomes in Older Adults with Traumatic Brain Injury and Association Between Social Determinants of Health and Intervention Effectiveness: A Scoping Review. 改善老年外伤性脑损伤患者认知结局的干预措施以及健康社会决定因素与干预效果之间的关系:一项范围综述
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.868
Yu Qing Huang, Harneet Hothi, Sophie Weiss, Peter Hoang, Jessie McGowan, Nathalie Bier, Sharon Elizabeth Straus, Jennifer Ann Watt

Background: At least one million Canadians are at risk of experiencing a traumatic brain injury (TBI) in later life, which can lead to cognitive decline. We identified interventions studied to improve cognitive outcomes in older adults with TBI, and examined how social determinants of health (SDoH) may influence their effectiveness.

Methods: We followed JBI guidance and searched five electronic databases from inception until March 2023 for studies evaluating the clinical and cost effectiveness, and safety of interventions being studied to improve cognitive outcomes in older adults with TBI. We abstracted SDoH following the PROGRESS-Plus framework.

Results: We included 20 studies and 44,462 predominantly men/male (65%) participants with a mean age of 65.9 years; studies reported 51 cognitive outcomes. Three studies reported on race or ethnicity, eight studies reported on education, and no studies differentiated gender from sex. No studies reported on the association between SDoH and intervention effectiveness. We did not identify any economic evaluations. We classified 10 interventions into four categories: non-pharmacologic cognitive strategies (number of studies [n]=16), medications (n=1), non-invasive procedures (n=2), and invasive procedures (n=1). Invasive procedures and non-pharmacologic cognitive strategies had a statistically significant positive effect on cognitive measures in one and seven studies, respectively. Non-invasive procedures (n=2) did not have significant cognitive effects. Use of hypnotics (benzodiazepines and non-benzodiazepines) was significantly associated with a shorter time to incident dementia in one study.

Conclusion: Non-pharmacologic cognitive strategies were the most-studied interventions for improving cognitive outcomes in older adults with TBI. Future research should better integrate a health equity lens and standardize outcome measurement.

背景:至少有一百万加拿大人在以后的生活中有经历创伤性脑损伤(TBI)的风险,这可能导致认知能力下降。我们确定了改善老年TBI患者认知结果的干预措施,并研究了健康的社会决定因素(SDoH)如何影响其有效性。方法:我们遵循JBI指南,检索了5个电子数据库,从成立到2023年3月,评估了正在研究的干预措施的临床、成本效益和安全性,以改善老年TBI患者的认知结局。我们按照PROGRESS-Plus框架抽象了SDoH。结果:我们纳入了20项研究和44,462名参与者,主要是男性/男性(65%),平均年龄为65.9岁;研究报告了51项认知结果。三项研究报告了种族或民族,八项研究报告了教育,没有研究区分性别和性。没有关于SDoH与干预效果之间关系的研究报道。我们没有进行任何经济评估。我们将10种干预措施分为四类:非药物认知策略(研究数量[n]=16)、药物治疗(n=1)、非侵入性治疗(n=2)和侵入性治疗(n=1)。在一项和七项研究中,侵入性手术和非药物认知策略分别对认知测量有统计学上显著的积极影响。非侵入性手术(n=2)没有显著的认知影响。在一项研究中,催眠药物(苯二氮卓类药物和非苯二氮卓类药物)的使用与较短的痴呆发生时间显著相关。结论:非药物认知策略是改善老年TBI患者认知结局研究最多的干预措施。未来的研究应更好地整合健康公平视角,并使结果测量标准化。
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引用次数: 0
Anti-Amyloid Therapies for Alzheimer's Disease: Not the Way Forward. 抗淀粉样蛋白治疗阿尔茨海默病:不是前进的方向。
IF 1.2 Q4 GERIATRICS & GERONTOLOGY Pub Date : 2025-12-03 eCollection Date: 2025-12-01 DOI: 10.5770/cgj.28.888
Christian Bocti, Howard Bergman
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引用次数: 0
期刊
Canadian Geriatrics Journal
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