Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study.

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Beilstein Journal of Nanotechnology Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.24
Zeynep Özcan, Afife Binnaz Hazar Yoruç
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Abstract

In this study, a multifunctional therapeutic agent combining chemotherapy and photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight ratios as a result of dopamine polymerisation and covalent bonding of thiol-polyethylene glycol (SH-PEG). The VNB/PDA/Fe3O4 nanoparticles have a saturation magnetisation value of 60.40 emu/g in vibrating sample magnetometry, which proves their magnetisation. Vinorelbine, which is used as an effective cancer therapy agent, is included in the nanocomposite structure, and in vitro drug release studies under different pH conditions (pH 5.5 and 7.4) and photothermal activity at 808 nm NIR laser irradiation are investigated. The comprehensive integration of precise multifunctional nanoparticles design, magnetic response, and controlled drug release with photothermal effect brings a different perspective to advanced cancer treatment research.

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作为抗癌药物输送系统的长春瑞滨负载多功能磁性纳米颗粒:合成、表征和体外释放研究。
本研究开发了一种多功能治疗剂,在单一平台上将化疗和光热疗法结合在一起,其形式是负载长春瑞滨的多巴胺包覆氧化铁纳米粒子。由于多巴胺聚合和硫醇-聚乙二醇(SH-PEG)的共价键作用,在不同重量比的聚多巴胺(PDA)包覆后,通过溶热技术制备的氧化铁纳米粒子表面负载了长春瑞滨(VNB)。在振动样品磁强计中,VNB/PDA/Fe3O4 纳米粒子的饱和磁化值为 60.40 emu/g,这证明了它们的磁性。在纳米复合结构中加入了可有效治疗癌症的长春瑞滨,并研究了不同 pH 条件(pH 5.5 和 7.4)下的体外药物释放研究和 808 纳米近红外激光照射下的光热活性。精确的多功能纳米颗粒设计、磁响应、药物控释与光热效应的综合集成为先进的癌症治疗研究带来了不同的视角。
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来源期刊
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
5.70
自引率
3.20%
发文量
109
审稿时长
2 months
期刊介绍: The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.
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