{"title":"Anti-<i>Staphylococcus aureus</i> effects of natural antimicrobial peptides and the underlying mechanisms.","authors":"Xueqi Chen, Jiuli Yang, Chang Qu, Qian Zhang, Shujuan Sun, Lihong Liu","doi":"10.2217/fmb-2023-0168","DOIUrl":null,"url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> can cause localized infections such as abscesses and pneumonia, as well as systemic infections such as bacteremia and sepsis. Especially, methicillin-resistant <i>S. aureus</i> often presents multidrug resistance, which becomes a major clinical challenge. One of the most common reasons for methicillin-resistant <i>S. aureus</i> antibiotic resistance is the presence of biofilms. Natural antimicrobial peptides derived from different species have shown effectiveness in combating <i>S. aureus</i> biofilms. In this review, we summarize the inhibitory activity of antimicrobial peptides against <i>S. aureus</i> planktonic cells and biofilms. We also summarize the possible inhibitory mechanisms, involving cell adhesion inhibition, membrane fracture, biofilm disruption and DNA disruption. We believe this can provide the basis for further research against <i>S. aureus</i> biofilm-associated infections.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2217/fmb-2023-0168","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Staphylococcus aureus can cause localized infections such as abscesses and pneumonia, as well as systemic infections such as bacteremia and sepsis. Especially, methicillin-resistant S. aureus often presents multidrug resistance, which becomes a major clinical challenge. One of the most common reasons for methicillin-resistant S. aureus antibiotic resistance is the presence of biofilms. Natural antimicrobial peptides derived from different species have shown effectiveness in combating S. aureus biofilms. In this review, we summarize the inhibitory activity of antimicrobial peptides against S. aureus planktonic cells and biofilms. We also summarize the possible inhibitory mechanisms, involving cell adhesion inhibition, membrane fracture, biofilm disruption and DNA disruption. We believe this can provide the basis for further research against S. aureus biofilm-associated infections.
金黄色葡萄球菌可引起脓肿和肺炎等局部感染，以及菌血症和败血症等全身感染。尤其是耐甲氧西林的金黄色葡萄球菌往往具有多重耐药性，成为临床上的一大难题。耐甲氧西林金黄色葡萄球菌产生抗生素耐药性的最常见原因之一是生物膜的存在。从不同物种中提取的天然抗菌肽已显示出对抗金黄色葡萄球菌生物膜的有效性。在这篇综述中，我们总结了抗菌肽对金黄色葡萄球菌浮游细胞和生物膜的抑制活性。我们还总结了可能的抑制机制，包括细胞粘附抑制、膜断裂、生物膜破坏和 DNA 破坏。我们相信这能为进一步研究金黄色葡萄球菌生物膜相关感染提供基础。
期刊介绍：
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
