Major depressive disorder and the risk of irritable bowel syndrome: A Mendelian randomization study.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY Molecular Genetics & Genomic Medicine Pub Date : 2024-03-01 DOI:10.1002/mgg3.2413

Ruiming Zhu, Nan Zhang, He Zhu, Fudong Li, Hong Xu

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Abstract

Background: The association between major depressive disorder (MDD) and irritable bowel syndrome (IBS) has been found in observational research; however, the causative relationship between MDD and IBS remains uncertain. Using the two-sample Mendelian randomization (MR) approach, we attempted to examine the causal effect of MDD on IBS.

Methods: Independent genetic variants for MDD identified by Howard et al. based on a genome-wide meta-analysis were selected for this study. Gene-Outcome associations for IBS were gathered from UK Biobank and FinnGen databases. The MR analysis included inverse variance weighted (IVW), MR-Egger regression, weighted median, weighted mode, and MR-PRESSO sensitivity analyses.

Results: FinnGen database subjected to inverse variance weighted (IVW) analysis revealed that MDD may be a risk factor for the development of IBS (OR = 1.356, 95% CI: 1.125-1.632, p = 0.0013). The same finding was reached in UK Biobank for IVW (OR = 1.011, 95% CI: 1.006-1.015, p = 3.18 × 10^-7 ), MR-Egger progression (OR = 1.030, 95% CI: 1.008-1.051, p = 0.007), and weighted median (OR = 1.011, 95% CI: 1.005-1.016, p = 0.0001).

Conclusion: Our findings supported a causal relationship between MDD and IBS, which may have implications for the clinical management of IBS in individuals with MDD.

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重度抑郁症与肠易激综合征的风险：孟德尔随机研究

背景：观察性研究发现，重性抑郁障碍（MDD）与肠易激综合征（IBS）之间存在关联；然而，MDD与IBS之间的因果关系仍不确定。我们尝试使用双样本孟德尔随机化（MR）方法来研究 MDD 对肠易激综合征的因果关系：本研究选择了 Howard 等人根据全基因组荟萃分析确定的 MDD 独立遗传变异。从英国生物库和芬兰基因数据库中收集了肠易激综合征的基因-结果关联。MR分析包括逆方差加权（IVW）、MR-Egger回归、加权中位数、加权模式和MR-PRESSO敏感性分析：对芬兰基因数据库进行逆方差加权（IVW）分析后发现，多发性抑郁症可能是肠易激综合征发病的一个风险因素（OR = 1.356，95% CI：1.125-1.632，p = 0.0013）。英国生物库的IVW（OR = 1.011，95% CI：1.006-1.015，p = 3.18 × 10-7）、MR-Egger进展（OR = 1.030，95% CI：1.008-1.051，p = 0.007）和加权中位数（OR = 1.011，95% CI：1.005-1.016，p = 0.0001）也得出了同样的结论：我们的研究结果表明，多发性抑郁症与肠易激综合征之间存在因果关系，这可能会对多发性抑郁症患者肠易激综合征的临床治疗产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Genetics & Genomic Medicine Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.20

自引率

0.00%

发文量

241

审稿时长

14 weeks

期刊介绍： Molecular Genetics & Genomic Medicine is a peer-reviewed journal for rapid dissemination of quality research related to the dynamically developing areas of human, molecular and medical genetics. The journal publishes original research articles covering findings in phenotypic, molecular, biological, and genomic aspects of genomic variation, inherited disorders and birth defects. The broad publishing spectrum of Molecular Genetics & Genomic Medicine includes rare and common disorders from diagnosis to treatment. Examples of appropriate articles include reports of novel disease genes, functional studies of genetic variants, in-depth genotype-phenotype studies, genomic analysis of inherited disorders, molecular diagnostic methods, medical bioinformatics, ethical, legal, and social implications (ELSI), and approaches to clinical diagnosis. Molecular Genetics & Genomic Medicine provides a scientific home for next generation sequencing studies of rare and common disorders, which will make research in this fascinating area easily and rapidly accessible to the scientific community. This will serve as the basis for translating next generation sequencing studies into individualized diagnostics and therapeutics, for day-to-day medical care. Molecular Genetics & Genomic Medicine publishes original research articles, reviews, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented.