Development and Evaluation of a Portable MVT-Based All-Digital Helmet PET Scanner

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2024-01-23 DOI:10.1109/TRPMS.2024.3357571
Feng Zhou;Nicola D’Ascenzo;Bo Zhang;Emanuele Antonecchia;Lei Fang;Li Ba;Min Zhang;Xiaohua Zhu;Qiong Liu;Jiazuan Ni;Giacomo Frati;Michael Kreissl;Xun Chen;Jiang Wu;Qingguo Xie
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Abstract

Novel design solutions for dedicated portable brain positron emission tomography systems with improved performance facilitate emergency and interventional image-guided surgery as well as advanced diagnostics of clinically impaired patients with neurodegenerative diseases. We report a novel portable MVT-based All-Digital helmet PET system with a hemispherical detector arrangement based on the Multi Voltage Threshold technology. It has a transverse and axial field of view (FOV) of 200 and 124 mm, respectively. It allows to scan subjects in a standing, sitting, and lying position. We evaluated the performance of the system according to NEMA standards. The scanner exhibits a noise equivalent count rate peak of $\mathbf {(151\pm 2)}$ kcps at the activity of 40.65 kBq/mL, a sensitivity of $\mathbf {(55.24\pm 0.05)}$ cps/kBq, and a spatial resolution at the center of the FOV of approximately 3.3 mm (FWHM), when using the filtered back projection algorithm. For a mini Derenzo phantom, rods of 2.0-mm diameter can be clearly separated. Time-dynamic [ $\mathbf {^{18}}\text{F}$ ]-Fluorodeoxyglucose human brain imaging was performed, showing the distinctive traits of cortex and thalamus uptake, as well as of the arterial and venous flow with 30 s time frames. We finally verified the usability of the device in the diagnostics of Alzheimer’s Disease by imaging human subjects with [ $\mathbf {^{18}}\text{F}$ ]-Florbetapir.
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开发和评估基于 MVT 的便携式全数字头盔 PET 扫描仪
专用便携式脑正电子发射计算机断层成像系统的新型设计方案性能更佳,有助于急诊和介入图像引导手术,以及对临床受损的神经退行性疾病患者进行高级诊断。我们报告了一种基于多电压阈值技术的新型便携式全数字头盔正电子发射计算机断层成像系统,该系统采用半球形探测器布置,以多电压阈值技术为基础。它的横向和轴向视场(FOV)分别为 200 毫米和 124 毫米。它可以扫描站姿、坐姿和躺姿的受试者。我们根据 NEMA 标准对该系统的性能进行了评估。在活性为 40.65 kBq/mL 时,扫描仪的噪声等效计数率峰值为 $\mathbf {(151\pm 2)}$ kcps,灵敏度为 $\mathbf {(55.24\pm 0.05)}$ cps/kBq,使用滤波背投算法时,FOV 中心的空间分辨率约为 3.3 mm (FWHM)。对于微型德伦佐幻影,直径为 2.0 毫米的棒可被清晰地分离出来。我们还进行了时间动态[$\mathbf {^{18}}\text{F}$ ]-氟脱氧葡萄糖人脑成像,显示了大脑皮层和丘脑摄取的明显特征,以及30秒时限内的动脉和静脉血流。最后,我们用[$\mathbf {^{18}}text{F}$ ]-Florbetapir 对受试者进行成像,验证了该设备在阿尔茨海默病诊断中的可用性。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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