{"title":"Development and Evaluation of a Portable MVT-Based All-Digital Helmet PET Scanner","authors":"Feng Zhou;Nicola D’Ascenzo;Bo Zhang;Emanuele Antonecchia;Lei Fang;Li Ba;Min Zhang;Xiaohua Zhu;Qiong Liu;Jiazuan Ni;Giacomo Frati;Michael Kreissl;Xun Chen;Jiang Wu;Qingguo Xie","doi":"10.1109/TRPMS.2024.3357571","DOIUrl":null,"url":null,"abstract":"Novel design solutions for dedicated portable brain positron emission tomography systems with improved performance facilitate emergency and interventional image-guided surgery as well as advanced diagnostics of clinically impaired patients with neurodegenerative diseases. We report a novel portable MVT-based All-Digital helmet PET system with a hemispherical detector arrangement based on the Multi Voltage Threshold technology. It has a transverse and axial field of view (FOV) of 200 and 124 mm, respectively. It allows to scan subjects in a standing, sitting, and lying position. We evaluated the performance of the system according to NEMA standards. The scanner exhibits a noise equivalent count rate peak of \n<inline-formula> <tex-math>$\\mathbf {(151\\pm 2)}$ </tex-math></inline-formula>\n kcps at the activity of 40.65 kBq/mL, a sensitivity of \n<inline-formula> <tex-math>$\\mathbf {(55.24\\pm 0.05)}$ </tex-math></inline-formula>\n cps/kBq, and a spatial resolution at the center of the FOV of approximately 3.3 mm (FWHM), when using the filtered back projection algorithm. For a mini Derenzo phantom, rods of 2.0-mm diameter can be clearly separated. Time-dynamic [\n<inline-formula> <tex-math>$\\mathbf {^{18}}\\text{F}$ </tex-math></inline-formula>\n]-Fluorodeoxyglucose human brain imaging was performed, showing the distinctive traits of cortex and thalamus uptake, as well as of the arterial and venous flow with 30 s time frames. We finally verified the usability of the device in the diagnostics of Alzheimer’s Disease by imaging human subjects with [\n<inline-formula> <tex-math>$\\mathbf {^{18}}\\text{F}$ </tex-math></inline-formula>\n]-Florbetapir.","PeriodicalId":46807,"journal":{"name":"IEEE Transactions on Radiation and Plasma Medical Sciences","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Radiation and Plasma Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/10413201/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Novel design solutions for dedicated portable brain positron emission tomography systems with improved performance facilitate emergency and interventional image-guided surgery as well as advanced diagnostics of clinically impaired patients with neurodegenerative diseases. We report a novel portable MVT-based All-Digital helmet PET system with a hemispherical detector arrangement based on the Multi Voltage Threshold technology. It has a transverse and axial field of view (FOV) of 200 and 124 mm, respectively. It allows to scan subjects in a standing, sitting, and lying position. We evaluated the performance of the system according to NEMA standards. The scanner exhibits a noise equivalent count rate peak of
$\mathbf {(151\pm 2)}$
kcps at the activity of 40.65 kBq/mL, a sensitivity of
$\mathbf {(55.24\pm 0.05)}$
cps/kBq, and a spatial resolution at the center of the FOV of approximately 3.3 mm (FWHM), when using the filtered back projection algorithm. For a mini Derenzo phantom, rods of 2.0-mm diameter can be clearly separated. Time-dynamic [
$\mathbf {^{18}}\text{F}$
]-Fluorodeoxyglucose human brain imaging was performed, showing the distinctive traits of cortex and thalamus uptake, as well as of the arterial and venous flow with 30 s time frames. We finally verified the usability of the device in the diagnostics of Alzheimer’s Disease by imaging human subjects with [
$\mathbf {^{18}}\text{F}$
]-Florbetapir.