{"title":"Fragments Synthesis of A. baumannii ATCC 17961 O-Antigen","authors":"Xinxin Li, Liangshen Duan, Deyong Liu, Jianying Qi, Liming Wang, Qingju Zhang","doi":"10.1055/a-2272-8163","DOIUrl":null,"url":null,"abstract":"<p>\n<i>Acinetobacter baumannii</i> can cause many diseases including septicemia, pneumonia, meningitis, soft tissue, and urinary tract infections. Herein, we described the synthesis of one trisaccharide and two tetrasaccharide fragments derived from <i>A. baumannii</i> ATCC 17961 O-antigen that can be used for screening novel glyco-epitopes and for developing a synthetic carbohydrate-based vaccine against <i>A. baumannii</i> infection. The overall yields for the synthesis of the desired trisaccharide <b>1</b>, tetrasaccharide <b>2</b>, and tetrasaccharide <b>3 </b>are 26.8% (8 steps), 21.6% (9 steps), and 24.5% (6 steps), respectively.</p> ","PeriodicalId":22319,"journal":{"name":"Synlett","volume":"60 1","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synlett","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1055/a-2272-8163","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Acinetobacter baumannii can cause many diseases including septicemia, pneumonia, meningitis, soft tissue, and urinary tract infections. Herein, we described the synthesis of one trisaccharide and two tetrasaccharide fragments derived from A. baumannii ATCC 17961 O-antigen that can be used for screening novel glyco-epitopes and for developing a synthetic carbohydrate-based vaccine against A. baumannii infection. The overall yields for the synthesis of the desired trisaccharide 1, tetrasaccharide 2, and tetrasaccharide 3 are 26.8% (8 steps), 21.6% (9 steps), and 24.5% (6 steps), respectively.
期刊介绍：
SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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