{"title":"Hypoglycemic effects of dracorhodin and dragon blood crude extract from Daemonorops draco.","authors":"Yung-Hao Ching, Fang-Mei Lin, Hong-Chi Chen, Ching-Yun Hsu, Sze Yen P'ng, Tai-No Lin, Yu-Chia Wang, Cheng-Jun Lin, Yi-Chi Chen, Tsung-Jung Ho, Hao-Ping Chen","doi":"10.1186/s40529-024-00415-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Dragon blood is a red fruit resin from the palm tree Daemonorops draco and is a herbal ingredient used in the traditional Chinese medicine, \"Jinchuang Ointment,\" which is used to treat non-healing diabetic wounds. According to the Taiwan Herbal Pharmacopeia, the dracorhodin content in dragon blood should exceed 1.0%.</p><p><strong>Results: </strong>Our findings indicate that dracorhodin and dragon blood crude extracts can stimulate glucose uptake in mouse muscle cells (C2C12) and primary rat aortic smooth muscle cells (RSMC). Dracorhodin is not the only active compound in dragon blood crude extracts from D. draco. Next, we orally administered crude dragon blood extracts to male B6 mice. The experimental group displayed a decreasing trend in fasting blood glucose levels from the second to tenth week. In summary, crude extracts of dragon blood from D. draco demonstrated in vivo hypoglycemic effects in B6 male mice.</p><p><strong>Conclusions: </strong>We provide a scientific basis \"Jinchuang ointment\" in treating non-healing wounds in patients with diabetes.</p>","PeriodicalId":9185,"journal":{"name":"Botanical Studies","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917723/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Botanical Studies","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s40529-024-00415-1","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
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Abstract
Background: Dragon blood is a red fruit resin from the palm tree Daemonorops draco and is a herbal ingredient used in the traditional Chinese medicine, "Jinchuang Ointment," which is used to treat non-healing diabetic wounds. According to the Taiwan Herbal Pharmacopeia, the dracorhodin content in dragon blood should exceed 1.0%.
Results: Our findings indicate that dracorhodin and dragon blood crude extracts can stimulate glucose uptake in mouse muscle cells (C2C12) and primary rat aortic smooth muscle cells (RSMC). Dracorhodin is not the only active compound in dragon blood crude extracts from D. draco. Next, we orally administered crude dragon blood extracts to male B6 mice. The experimental group displayed a decreasing trend in fasting blood glucose levels from the second to tenth week. In summary, crude extracts of dragon blood from D. draco demonstrated in vivo hypoglycemic effects in B6 male mice.
Conclusions: We provide a scientific basis "Jinchuang ointment" in treating non-healing wounds in patients with diabetes.
期刊介绍：
Botanical Studies is an open access journal that encompasses all aspects of botany, including but not limited to taxonomy, morphology, development, genetics, evolution, reproduction, systematics, and biodiversity of all plant groups, algae, and fungi. The journal is affiliated with the Institute of Plant and Microbial Biology, Academia Sinica, Taiwan.
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