Study of erythrocyte sedimentation in human blood through the photoacoustic signals analysis

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2024-03-02 DOI:10.1016/j.pacs.2024.100599

Argelia Pérez-Pacheco , Roberto G. Ramírez-Chavarría , Marco Polo Colín-García , Flor del Carmen Cortés-Ortegón , Rosa María Quispe-Siccha , Adolfo Martínez‑Tovar , Irma Olarte‑Carrillo , Luis Polo-Parada , Gerardo Gutiérrez-Juárez

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Abstract

Introduction

In this study, we utilized the pulsed photoacoustic (PA) technique to analyze globular sedimentation in whole human blood, with a focus on distinguishing between healthy individuals and those with hemolytic anemia.

Methods

Blood samples were collected from both healthy individuals (women and men) and those with hemolytic anemia, and temporal and spectral parameters of PA signals were employed for analysis.

Results

Significant differences (p < 0.05) were observed in PA metrics between the two groups. The proposed spectral analysis allowed significant differentiation within a 25-minute measurement window. Anemic blood samples exhibited higher erythrocyte sedimentation rate (ESR) values, indicating increased erythrocyte aggregation.

Discussion

This study underscores the potential of PA signal analysis in ESR assessment as an efficient method for distinguishing between healthy and anemic blood, surpassing traditional approaches. It represents a promising contribution to the development of precise and sensitive techniques for analyzing human blood samples in clinical settings.

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通过光声信号分析研究人体血液中的红细胞沉降。

在这项研究中，我们利用脉冲光声（PA）技术分析了全人类血液中的球状沉淀，重点是区分健康人和溶血性贫血患者。采集了健康人（女性和男性）和溶血性贫血患者的血液样本，并采用 PA 信号的时间和光谱参数进行分析。两组患者的 PA 指标有显著差异（P < 0.05）。拟议的频谱分析可在 25 分钟的测量窗口内进行显著区分。贫血血样的红细胞沉降率（ESR）值较高，表明红细胞聚集增加。这项研究强调了 PA 信号分析在血沉评估中的潜力，它是区分健康和贫血血液的有效方法，超越了传统方法。它为临床环境中精确、灵敏的人体血液样本分析技术的发展做出了巨大贡献。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.