Interplay between group A Streptococcus and host innate immune responses.

IF 8 1区 生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-03-07 DOI:10.1128/mmbr.00052-22
Marcia Shu-Wei Su, Yi-Lin Cheng, Yee-Shin Lin, Jiunn-Jong Wu
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Abstract

SUMMARYGroup A Streptococcus (GAS), also known as Streptococcus pyogenes, is a clinically well-adapted human pathogen that harbors rich virulence determinants contributing to a broad spectrum of diseases. GAS is capable of invading epithelial, endothelial, and professional phagocytic cells while evading host innate immune responses, including phagocytosis, selective autophagy, light chain 3-associated phagocytosis, and inflammation. However, without a more complete understanding of the different ways invasive GAS infections develop, it is difficult to appreciate how GAS survives and multiplies in host cells that have interactive immune networks. This review article attempts to provide an overview of the behaviors and mechanisms that allow pathogenic GAS to invade cells, along with the strategies that host cells practice to constrain GAS infection. We highlight the counteractions taken by GAS to apply virulence factors such as streptolysin O, nicotinamide-adenine dinucleotidase, and streptococcal pyrogenic exotoxin B as a hindrance to host innate immune responses.

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A 群链球菌与宿主先天性免疫反应之间的相互作用。
摘要 A 组链球菌(GAS)又称化脓性链球菌,是一种临床上适应性很强的人类病原体,具有丰富的毒力决定因素,可导致多种疾病。GAS 能够侵入上皮细胞、内皮细胞和专业吞噬细胞,同时躲避宿主的先天性免疫反应,包括吞噬、选择性自噬、轻链 3 相关吞噬和炎症反应。然而,如果不能更全面地了解侵袭性 GAS 感染的不同发展方式,就很难理解 GAS 是如何在具有交互免疫网络的宿主细胞中存活和繁殖的。这篇综述文章试图概述致病性 GAS 入侵细胞的行为和机制,以及宿主细胞限制 GAS 感染的策略。我们重点介绍了 GAS 应用链溶菌素 O、烟酰胺腺嘌呤二核苷酸酶和链球菌热原外毒素 B 等毒力因子阻碍宿主先天性免疫反应的对策。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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