Analysis of Serum Anti-HBs Levels and HBsAg/HBeAg Markers in Children and Adolescents: A Cross-Sectional Study.

IF 1.5 4区医学 Q4 IMMUNOLOGY Viral immunology Pub Date : 2024-03-01 Epub Date: 2024-03-06 DOI:10.1089/vim.2023.0121

Zhili Niu, Pingan Zhang

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Abstract

Hepatitis B virus (HBV) is a global public health concern, and China continues to face a high burden of HBV cases. Vaccination plays a critical role in controlling and eradicating HBV. However, studies have shown that some individuals may experience waning immunity over time, highlighting the importance of enhanced immunization strategies. This study aimed to investigate the relationship between age, gender, and anti-HBs antibody levels, as well as the prevalence of serum hepatitis B surface antigen (HBsAg)/HBV e antigen (HBeAg) positivity. This retrospective study included 43,609 pediatric patients who visited the outpatient department between January 2013 and December 2022. Serum biomarkers (HBsAg, anti-HBs, HBeAg, anti-HBe, and anti-HBc) were measured using Roche Cobas 8000. There is a significant difference in anti-HBs titer between genders and across different age groups (p < 0.05). The serological markers HBsAg/HBeAg exhibited the highest positivity rate in the age group of 15-18 years. The findings demonstrate a gradual decrease in anti-HBs levels following HBV vaccination. The prevalence of serum markers HBsAg/HBeAg is higher among adolescents aged 15-18 years, which should be a matter of concern and attention.

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儿童和青少年血清抗-HBs 水平和 HBsAg/HBeAg 标记物分析：一项横断面研究

乙型肝炎病毒（HBV）是全球关注的公共卫生问题，而中国仍然面临着 HBV 病例高负担的问题。疫苗接种在控制和根除 HBV 方面发挥着至关重要的作用。然而，研究表明，随着时间的推移，一些人的免疫力可能会下降，这就凸显了加强免疫策略的重要性。本研究旨在调查年龄、性别和抗 HBs 抗体水平之间的关系，以及血清乙型肝炎表面抗原（HBsAg）/乙型肝炎病毒 e 抗原（HBeAg）阳性率。这项回顾性研究纳入了2013年1月至2022年12月期间在门诊部就诊的43609名儿科患者。血清生物标记物（HBsAg、抗-HBs、HBeAg、抗-HBe和抗-HBc）由罗氏Cobas 8000测定。不同性别和不同年龄组的抗-HBs 滴度有明显差异（p

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来源期刊

Viral immunology 医学-病毒学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines. Viral Immunology coverage includes: Human and animal viral immunology Research and development of viral vaccines, including field trials Immunological characterization of viral components Virus-based immunological diseases, including autoimmune syndromes Pathogenic mechanisms Viral diagnostics Tumor and cancer immunology with virus as the primary factor Viral immunology methods.