Supercharging cancer-fighting T cells with lithium carbonate.

Yue Xu, Kaili Ma, Lianjun Zhang, Guideng Li
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Abstract

Lactate influences the behavior of various immune cell types. In a recent Nature Immunology study, Ma et al. revealed that lithium carbonate induces monocarboxylate transporter 1 translocation to mitochondria, enhancing cytoplasmic lactate transport into the mitochondria and increasing lactate mitochondrial metabolism, thereby promoting T cell effector function.

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用碳酸锂为抗癌 T 细胞充电。
乳酸盐会影响各种免疫细胞的行为。在最近的《自然-免疫学》(Nature Immunology)研究中,Ma 等人发现碳酸锂能诱导单羧酸盐转运体 1 转位至线粒体,增强细胞质中乳酸向线粒体的转运,增加乳酸线粒体代谢,从而促进 T 细胞效应器功能。
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