A Case of Type I Food Allergy Induced by Monosodium Glutamate

IF 3.7 3区医学 Q2 ALLERGY Journal of Asthma and Allergy Pub Date : 2024-03-07 DOI:10.2147/jaa.s451911

Reeko Osada, Chiyako Oshikata, Yuichi Kurihara, Kosuke Terada, Yuka Kodama, Yuga Yamashita, Ryo Nakadegawa, Hinako Masumitsu, Yuto Motobayashi, Hirokazu Takayasu, Nami Masumoto, Saki Manabe, Yingyao Zhu, Ryo Tanaka, Takeshi Kaneko, Aya Sasaki, Naomi Tsurikisawa

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Abstract

Abstract: Monosodium glutamate (MSG), a salt form of a non-essential amino acid, is widely used as a food additive, particularly in Asian cuisines, due to its unique flavor-enhancing qualities. Type I allergic reactions to MSG have not previously been reported. Our patient, a 21-year-old woman, was 14 years old when she first noticed swelling of her tongue (but no oral itching, diarrhea, or abdominal pain) after eating various snack foods. Current skin prick testing elicited a weak positive reaction to MSG. We then performed an oral challenge test during which our patient ingested potato snacks. Subsequent histology showed telangiectasia of the buccal mucosa, interstitial edema in the subepithelial submucosa, and mast cell infiltration. Oral mucosal challenge tests using sodium glutamate confirmed oral swelling in this patient. This report is the first to confirm a case of type 1 allergy to MSG by combining pathology findings with the results of challenge testing.

Keywords: food additive, mast cell, monosodium glutamate, food allergy

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一个由谷氨酸钠诱发的 I 型食物过敏病例

摘要：谷氨酸钠（味精）是一种非必需氨基酸的盐类，因其独特的增味作用而被广泛用作食品添加剂，尤其是在亚洲菜肴中。味精引起的 I 型过敏反应此前尚未见报道。我们的患者是一名 21 岁的女性，她在 14 岁时第一次发现自己在食用各种零食后舌头肿胀（但没有出现口腔瘙痒、腹泻或腹痛）。目前的皮肤点刺试验显示她对味精的反应呈弱阳性。随后，我们对患者进行了口腔挑战试验，患者在试验过程中吃了马铃薯零食。随后的组织学检查显示，患者的口腔黏膜出现毛细血管扩张，黏膜上皮下出现间质水肿，肥大细胞浸润。使用谷氨酸钠进行的口腔粘膜挑战试验证实了该患者的口腔肿胀。本报告是首例通过将病理学发现与挑战试验结果相结合来证实味精 1 型过敏的病例。关键词：食品添加剂、肥大细胞、谷氨酸钠、食物过敏

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.